This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Diazepam: Difference between revisions
>Blackhole added drugs-forum link |
>Supertzar Fixed misleading statement suggesting Diazepam is a naturally occurring substance found in plants and animals. |
||
| Line 13: | Line 13: | ||
It should be noted that [[Benzodiazepine#Discontinuation|the sudden discontinuation of benzodiazepines]] can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death.<ref name="Lann2009">{{cite journal | vauthors=((Lann, M. A.)), ((Molina, D. K.)) | journal=The American Journal of Forensic Medicine and Pathology | title=A fatal case of benzodiazepine withdrawal | volume=30 | issue=2 | pages=177–179 | date= June 2009 | issn=1533-404X | doi=10.1097/PAF.0b013e3181875aa0}}</ref> It is highly recommended to [[taper]] one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.<ref>{{cite journal | vauthors=((Kahan, M.)), ((Wilson, L.)), ((Mailis-Gagnon, A.)), ((Srivastava, A.)) | journal=Canadian Family Physician | title=Canadian guideline for safe and effective use of opioids for chronic noncancer pain. Appendix B-6: Benzodiazepine Tapering | volume=57 | issue=11 | pages=1269–1276 | date= November 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215603/ | issn=0008-350X}}</ref> | It should be noted that [[Benzodiazepine#Discontinuation|the sudden discontinuation of benzodiazepines]] can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death.<ref name="Lann2009">{{cite journal | vauthors=((Lann, M. A.)), ((Molina, D. K.)) | journal=The American Journal of Forensic Medicine and Pathology | title=A fatal case of benzodiazepine withdrawal | volume=30 | issue=2 | pages=177–179 | date= June 2009 | issn=1533-404X | doi=10.1097/PAF.0b013e3181875aa0}}</ref> It is highly recommended to [[taper]] one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.<ref>{{cite journal | vauthors=((Kahan, M.)), ((Wilson, L.)), ((Mailis-Gagnon, A.)), ((Srivastava, A.)) | journal=Canadian Family Physician | title=Canadian guideline for safe and effective use of opioids for chronic noncancer pain. Appendix B-6: Benzodiazepine Tapering | volume=57 | issue=11 | pages=1269–1276 | date= November 2011 | url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215603/ | issn=0008-350X}}</ref> | ||
While diazepam itself does not naturally occur in plants or animals, recent research has indicated that low concentrations of its major metabolite, desmethyldiazepam (DD), can be found in various biological systems, including those of animals and certain plants. This raises intriguing questions about the potential for these compounds to enter the food chain and their possible natural origins. However, the clinical significance and biological roles of these findings are still being explored.<ref>{{cite journal|last1=Unseld|first1=E.|last2=Krishna|first2=D. R.|last3=Fischer|first3=C.|last4=Klotz|first4=U.|title=Detection of desmethyldiazepam and diazepam in brain of different species and plants|year=1989|journal=Biochemical Pharmacology|volume=38|issue=15|pages=2473-2478|doi=10.1016/0006-2952(89)90091-9|issn=0006-2952|eissn=1873-2968|oclc=01536391|pmid=2502983}}</ref><ref>[https://pubmed.ncbi.nlm.nih.gov/2502983/]</ref> | |||
==History and culture== | ==History and culture== | ||