Cocaine/Synthesis: Difference between revisions

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__NOTOC__

<nomobile>{{decree|type=delete|message=WARNING!!! The anticholinergic tropane alkaloids used are EXTREMELY POISONOUS and can be ABSORBED THROUGH THE SKIN!!! Please take EXTREME precautions when handling these plants and the resulting anticholinergic tropane alkaloids that lie within. You must give these plants great respect or they will punish you severely. In lieu of waterproof lab attire, using large disposable trash bags to cover the head, ~~body~~, ~~legs~~, and ~~arms~~, as well as safety glasses for the face is ABSOLUTELY NECESSARY!!! Physostigmine, a cholinergic agent, is the chemical used to reverse the anticholinergic effects and poisoning of the tropane alkaloids. It occurs naturally in the Calabar bean and the fruit of the Manchineel tree. It is an extremely toxic substance with a mechanism of action similar to nerve gas.}}</nomobile>

<nomobile>{{decree|type=delete|message=WARNING!!! The anticholinergic tropane alkaloids used are EXTREMELY POISONOUS and can be ABSORBED THROUGH THE SKIN!!! Please take EXTREME precautions when handling these plants and the resulting anticholinergic tropane alkaloids that lie within. You must give these plants great respect or they will punish you severely. In lieu of waterproof lab attire, using large disposable trash bags to cover your full body; the head, torso, hands, arms, and legs, as well as safety glasses for the face is ABSOLUTELY NECESSARY!!! Physostigmine, a cholinergic agent, is the chemical used to reverse the anticholinergic effects and poisoning of the tropane alkaloids. It occurs naturally in the Calabar bean and the fruit of the Manchineel tree. It is an extremely toxic substance with a mechanism of action similar to nerve gas.}}</nomobile>

'''Overview'''

Here we are obtaining tropine to create tropinone from a natural source; the anticholinergic tropane alkaloids such as [[atropine]], [[scopolamine]], [[hyocyamine]], mandragovine, and other similar [[Tropane Alkaloids|tropane alkaloids]] obtained from the plants in the [https://en.wikipedia.org/wiki/Solanaceae Solanaceae family], such Belladonna, Datura, Henbane, Brugmansia, and Mandrake. Tropane alkaloids all contain the tropane ring which, when separated from the tropic, scopic, and hyoscopic, and similar acids becomes tropine, which we can use as a source chemical to produce tropinone, which is necessary for creation of synthetic cocaine. These plants grow in most of the parts of the world. With this semi-synthetic synthesis we can grow these plants nearly anywhere in the world, make cocaine cheaply within the country without having to transport it or cut it, to ensure harm reduction and that the cartels, traffickers, and other such dangerous criminals are out of a job.

Here we are obtaining tropine to create tropinone from a natural source; the anticholinergic [[Tropane Alkaloids|tropane alkaloids]] such as [[atropine]], [[scopolamine]], [[hyocyamine]], mandragovine, and other similar [[Tropane Alkaloids|tropane alkaloids]] obtained from the plants in the [https://en.wikipedia.org/wiki/Solanaceae Solanaceae family], such Belladonna, Datura, Henbane, Brugmansia, and Mandrake. [[Tropane Alkaloids|Tropane alkaloids]] all contain the tropane ring which, when separated from the tropic, scopic, and hyoscopic, and similar acids becomes tropine, which we can use as a source chemical to produce tropinone, which is necessary for creation of synthetic cocaine. These plants grow in most of the parts of the world. With this semi-synthetic synthesis we can grow these plants nearly anywhere in the world, make cocaine cheaply within the country without having to transport it or cut it, to ensure harm reduction and that the cartels, traffickers, and other such dangerous criminals are out of a job.

'''Extraction'''

Line 76:

'''Hydrogenation'''

For the hydrogenation reaction above we can use a (sealable) conductive metal container or two conductive metal objects in the ethanoic solution containing the NaOH acting as an electrolyte. We can set up an electrolysis reaction for a sort of sparging situation where hydrogen bubbles up through the (sealable) metal container acting like a hydrogenator. We can use any electricity source we choose, sealing the metal container and allowing the hydrogen gas to bubble up through the ethanoic solution, hydrogenating the 2-Carbomethoxytropinone into methylecgonine. This setup may be much easier and less suspicious than a conventional hydrogenator, and can be done in-situ.

For the hydrogenation reaction above we can use a (sealable) conductive metal container and a metal object or two conductive metal objects in the ethanoic solution containing the NaOH acting as an electrolyte. We can set up an electrolysis reaction for a sort of sparging situation where hydrogen bubbles up through the (sealable) metal container acting like a hydrogenator. We can use any electricity source we choose, sealing the metal container and allowing the hydrogen gas to bubble up through the ethanoic solution, hydrogenating the 2-Carbomethoxytropinone into methylecgonine. This setup may be much easier and less suspicious than a conventional hydrogenator, and can be done in-situ.

'''Fractional Crystallization'''

Cocaine has 16 sterioisomers, different configurations of the cocaine molecule. One of these is the cocaine we are looking for, the other sterioisomers are either inactive, or may be toxic. Since the sterioisomers have the same molecular mass we cannot use chromatography or distillation to separate them. Instead we dissolve the hydrochloride sterioisomers in a heated, aqueous supersaturated solution and then use a seed crystal of the cocaine hydrochloride isomer we are looking for and then lower the temperature of the supersaturated solution. This causes the correct cocaine hydrochloride sterioisomer to crystallize on the seed crystal. This is fractional crystallization and separates the correct sterioisomer from the rest of the other sterioisomers. A cocaine seed crystal can be obtained from an anhydrous acetone wash of street cocaine. Cocaine hydrochloride is completely insoluble in pure, anhydrous acetone, but all cutting agents are, dissolving them away leaving pure cocaine hydrochloride crystals, which can then be used for our fractional crystallization process.

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 __NOTOC__
-<nomobile>{{decree|type=delete|message=WARNING!!! The anticholinergic tropane alkaloids used are EXTREMELY POISONOUS and can be ABSORBED THROUGH THE SKIN!!! Please take EXTREME precautions when handling these plants and the resulting anticholinergic tropane alkaloids that lie within. You must give these plants great respect or they will punish you severely. In lieu of waterproof lab attire, using large disposable trash bags to cover the head, body, legs, and arms, as well as safety glasses for the face is ABSOLUTELY NECESSARY!!! Physostigmine, a cholinergic agent, is the chemical used to reverse the anticholinergic effects and poisoning of the tropane alkaloids. It occurs naturally in the Calabar bean and the fruit of the Manchineel tree. It is an extremely toxic substance with a mechanism of action similar to nerve gas.}}</nomobile>
+<nomobile>{{decree|type=delete|message=WARNING!!! The anticholinergic tropane alkaloids used are EXTREMELY POISONOUS and can be ABSORBED THROUGH THE SKIN!!! Please take EXTREME precautions when handling these plants and the resulting anticholinergic tropane alkaloids that lie within. You must give these plants great respect or they will punish you severely. In lieu of waterproof lab attire, using large disposable trash bags to cover your full body; the head, torso, hands, arms, and legs, as well as safety glasses for the face is ABSOLUTELY NECESSARY!!! Physostigmine, a cholinergic agent, is the chemical used to reverse the anticholinergic effects and poisoning of the tropane alkaloids. It occurs naturally in the Calabar bean and the fruit of the Manchineel tree. It is an extremely toxic substance with a mechanism of action similar to nerve gas.}}</nomobile>
 '''Overview'''
-Here we are obtaining tropine to create tropinone from a natural source; the anticholinergic tropane alkaloids such as [[atropine]], [[scopolamine]], [[hyocyamine]], mandragovine, and other similar [[Tropane Alkaloids|tropane alkaloids]] obtained from the plants in the [https://en.wikipedia.org/wiki/Solanaceae Solanaceae family], such Belladonna, Datura, Henbane, Brugmansia, and Mandrake. Tropane alkaloids all contain the tropane ring which, when separated from the tropic, scopic, and hyoscopic, and similar acids becomes tropine, which we can use as a source chemical to produce tropinone, which is necessary for creation of synthetic cocaine. These plants grow in most of the parts of the world. With this semi-synthetic synthesis we can grow these plants nearly anywhere in the world, make cocaine cheaply within the country without having to transport it or cut it, to ensure harm reduction and that the cartels, traffickers, and other such dangerous criminals are out of a job.
+Here we are obtaining tropine to create tropinone from a natural source; the anticholinergic [[Tropane Alkaloids|tropane alkaloids]] such as [[atropine]], [[scopolamine]], [[hyocyamine]], mandragovine, and other similar [[Tropane Alkaloids|tropane alkaloids]] obtained from the plants in the [https://en.wikipedia.org/wiki/Solanaceae Solanaceae family], such Belladonna, Datura, Henbane, Brugmansia, and Mandrake. [[Tropane Alkaloids|Tropane alkaloids]] all contain the tropane ring which, when separated from the tropic, scopic, and hyoscopic, and similar acids becomes tropine, which we can use as a source chemical to produce tropinone, which is necessary for creation of synthetic cocaine. These plants grow in most of the parts of the world. With this semi-synthetic synthesis we can grow these plants nearly anywhere in the world, make cocaine cheaply within the country without having to transport it or cut it, to ensure harm reduction and that the cartels, traffickers, and other such dangerous criminals are out of a job.
 '''Extraction'''
@@ Line 76: / Line 76: @@
 '''Hydrogenation'''
-For the hydrogenation reaction above we can use a (sealable) conductive metal container or two conductive metal objects in the ethanoic solution containing the NaOH acting as an electrolyte. We can set up an electrolysis reaction for a sort of sparging situation where hydrogen bubbles up through the (sealable) metal container acting like a hydrogenator. We can use any electricity source we choose, sealing the metal container and allowing the hydrogen gas to bubble up through the ethanoic solution, hydrogenating the 2-Carbomethoxytropinone into methylecgonine. This setup may be much easier and less suspicious than a conventional hydrogenator, and can be done in-situ.
+For the hydrogenation reaction above we can use a (sealable) conductive metal container and a metal object or two conductive metal objects in the ethanoic solution containing the NaOH acting as an electrolyte. We can set up an electrolysis reaction for a sort of sparging situation where hydrogen bubbles up through the (sealable) metal container acting like a hydrogenator. We can use any electricity source we choose, sealing the metal container and allowing the hydrogen gas to bubble up through the ethanoic solution, hydrogenating the 2-Carbomethoxytropinone into methylecgonine. This setup may be much easier and less suspicious than a conventional hydrogenator, and can be done in-situ.
 '''Fractional Crystallization'''
 Cocaine has 16 sterioisomers, different configurations of the cocaine molecule. One of these is the cocaine we are looking for, the other sterioisomers are either inactive, or may be toxic. Since the sterioisomers have the same molecular mass we cannot use chromatography or distillation to separate them. Instead we dissolve the hydrochloride sterioisomers in a heated, aqueous supersaturated solution and then use a seed crystal of the cocaine hydrochloride isomer we are looking for and then lower the temperature of the supersaturated solution. This causes the correct cocaine hydrochloride sterioisomer to crystallize on the seed crystal. This is fractional crystallization and separates the correct sterioisomer from the rest of the other sterioisomers. A cocaine seed crystal can be obtained from an anhydrous acetone wash of street cocaine. Cocaine hydrochloride is completely insoluble in pure, anhydrous acetone, but all cutting agents are, dissolving them away leaving pure cocaine hydrochloride crystals, which can then be used for our fractional crystallization process.