Cocaine/Synthesis: Difference between revisions

Line 68:

'''Extraction'''

A boiling water extraction is used to extract the [[Tropane Alkaloids|tropane alkaloids]] from the plant material. A sheet of cloth as a filter is put down in a container and water is boiled in said container. The plants are then pulled up by the roots, washed with water, and then placed in the container and pulverized and macerated while under the water with an appropriate utensil such as a piece of wood or a pipe. Keeping a lid on the container at all times will preclude spattering, ~~which could absorb~~ through your skin giving you anticholinergic poisoning. After the brew has boiled for some time pull up the cloth as a filter, leaving the extracted alkaloids in the water. Boil down the water for a concentrated solution of [[Tropane Alkaloids|tropane alkaloids]]. Multiple extractions of the same plant matter, and multiple extractions of different plant matter from another vessel(s) and transferred and boiled down in the main vessel will result in a concentrated aqueous solution of [[Tropane Alkaloids|tropane alkaloids]].

A boiling water extraction is used to extract the [[Tropane Alkaloids|tropane alkaloids]] from the plant material. A sheet of cloth as a filter is put down in a container and water is boiled in said container. The plants are then pulled up by the roots, washed with water, and then placed in the container and pulverized and macerated while under the water with an appropriate utensil such as a piece of wood or a pipe, which is also used to stir the brew. Keeping a lid on the container at all times will preclude spattering, the liquid possibly absorbing through your skin giving you anticholinergic poisoning. After the brew has boiled for some time pull up the cloth as a filter, leaving the extracted alkaloids in the water. Boil down the water for a concentrated solution of [[Tropane Alkaloids|tropane alkaloids]]. Multiple extractions of the same plant matter, and multiple extractions of different plant matter from another vessel(s) and transferred and boiled down in the main vessel will result in a concentrated aqueous solution of [[Tropane Alkaloids|tropane alkaloids]].

'''Hydrolysis'''

Line 80:

'''Fractional Crystallization'''

,

Cocaine has 16 sterioisomers, different configurations of the cocaine molecule. One of these is the cocaine we are looking for, the other sterioisomers are either inactive, or may be toxic. Since the sterioisomers have the same molecular mass we cannot use chromatography or distillation to separate them. Instead we dissolve the hydrochloride sterioisomers in a heated, aqueous supersaturated solution and then use a seed crystal of the cocaine isomer we are looking for and then lower the temperature of the supersaturated solution. This causes the correct cocaine sterioisomer to crystallize on the seed crystal. This is fractional crystallization and separates the correct sterioisomer from the rest of the other sterioisomers. A cocaine seed crystal can be obtained from an anhydrous acetone wash of street cocaine. Cocaine hydrochloride is completely insoluble in pure, anhydrous acetone, but all cutting agents are, dissolving them away leaving pure cocaine hydrochloride crystals, which can then be used for our fractional crystallization process.

Cocaine has 16 sterioisomers, different configurations of the cocaine molecule. One of these is the cocaine we are looking for, the other sterioisomers are either inactive, or may be toxic. Since the sterioisomers have the same molecular mass we cannot use chromatography or distillation to separate them. Instead we dissolve the hydrochloride sterioisomers in a heated, aqueous supersaturated solution and then use a seed crystal of the cocaine hydrochloride isomer we are looking for and then lower the temperature of the supersaturated solution. This causes the correct cocaine hydrochloride sterioisomer to crystallize on the seed crystal. This is fractional crystallization and separates the correct sterioisomer from the rest of the other sterioisomers. A cocaine seed crystal can be obtained from an anhydrous acetone wash of street cocaine. Cocaine hydrochloride is completely insoluble in pure, anhydrous acetone, but all cutting agents are, dissolving them away leaving pure cocaine hydrochloride crystals, which can then be used for our fractional crystallization process.

@@ Line 68: / Line 68: @@
 '''Extraction'''
-A boiling water extraction is used to extract the [[Tropane Alkaloids|tropane alkaloids]] from the plant material. A sheet of cloth as a filter is put down in a container and water is boiled in said container. The plants are then pulled up by the roots, washed with water, and then placed in the container and pulverized and macerated while under the water with an appropriate utensil such as a piece of wood or a pipe. Keeping a lid on the container at all times will preclude spattering, which could absorb through your skin giving you anticholinergic poisoning. After the brew has boiled for some time pull up the cloth as a filter, leaving the extracted alkaloids in the water. Boil down the water for a concentrated solution of [[Tropane Alkaloids|tropane alkaloids]]. Multiple extractions of the same plant matter, and multiple extractions of different plant matter from another vessel(s) and transferred and boiled down in the main vessel will result in a concentrated aqueous solution of [[Tropane Alkaloids|tropane alkaloids]].
+A boiling water extraction is used to extract the [[Tropane Alkaloids|tropane alkaloids]] from the plant material. A sheet of cloth as a filter is put down in a container and water is boiled in said container. The plants are then pulled up by the roots, washed with water, and then placed in the container and pulverized and macerated while under the water with an appropriate utensil such as a piece of wood or a pipe, which is also used to stir the brew. Keeping a lid on the container at all times will preclude spattering, the liquid possibly absorbing through your skin giving you anticholinergic poisoning. After the brew has boiled for some time pull up the cloth as a filter, leaving the extracted alkaloids in the water. Boil down the water for a concentrated solution of [[Tropane Alkaloids|tropane alkaloids]]. Multiple extractions of the same plant matter, and multiple extractions of different plant matter from another vessel(s) and transferred and boiled down in the main vessel will result in a concentrated aqueous solution of [[Tropane Alkaloids|tropane alkaloids]].
 '''Hydrolysis'''
@@ Line 80: / Line 80: @@
 '''Fractional Crystallization'''
 ,
-Cocaine has 16 sterioisomers, different configurations of the cocaine molecule. One of these is the cocaine we are looking for, the other sterioisomers are either inactive, or may be toxic. Since the sterioisomers have the same molecular mass we cannot use chromatography or distillation to separate them. Instead we dissolve the hydrochloride sterioisomers in a heated, aqueous supersaturated solution and then use a seed crystal of the cocaine isomer we are looking for and then lower the temperature of the supersaturated solution. This causes the correct cocaine sterioisomer to crystallize on the seed crystal. This is fractional crystallization and separates the correct sterioisomer from the rest of the other sterioisomers. A cocaine seed crystal can be obtained from an anhydrous acetone wash of street cocaine. Cocaine hydrochloride is completely insoluble in pure, anhydrous acetone, but all cutting agents are, dissolving them away leaving pure cocaine hydrochloride crystals, which can then be used for our fractional crystallization process.
+Cocaine has 16 sterioisomers, different configurations of the cocaine molecule. One of these is the cocaine we are looking for, the other sterioisomers are either inactive, or may be toxic. Since the sterioisomers have the same molecular mass we cannot use chromatography or distillation to separate them. Instead we dissolve the hydrochloride sterioisomers in a heated, aqueous supersaturated solution and then use a seed crystal of the cocaine hydrochloride isomer we are looking for and then lower the temperature of the supersaturated solution. This causes the correct cocaine hydrochloride sterioisomer to crystallize on the seed crystal. This is fractional crystallization and separates the correct sterioisomer from the rest of the other sterioisomers. A cocaine seed crystal can be obtained from an anhydrous acetone wash of street cocaine. Cocaine hydrochloride is completely insoluble in pure, anhydrous acetone, but all cutting agents are, dissolving them away leaving pure cocaine hydrochloride crystals, which can then be used for our fractional crystallization process.