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Tilidin: Difference between revisions
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#REDIRECT [[Tilidine]] | #REDIRECT [[Tilidine]] | ||
»Tilidine« has a potency of 0.16 to 0.19 and is therefore 16 - 19% as strong as morphine! | |||
❗Fatal risk of fatal overdose: ❗ | |||
- Alcohol | |||
- Benzodiazepines (Alprazolam, Lorazepam, Bromazepam, Valium®, etc.) | |||
- Other opiates/opioids (oxycodone, heroin, codeine, fentanyl, tramadol, etc.) | |||
- GHB/GBL | |||
- Z - Drugs (zopiclone, zolpidem, etc.) | |||
- Other depressants (Pregabalin, Phenibut, Mirtazapine) | |||
- Ketamines | |||
- Barbiturates | |||
-DXM | |||
-MXE | |||
- Thienodiazepines (Metizolam, Deschloroetizolam, etc.) | |||
- Grapefruit | |||
Be careful with: | |||
MAOIs | |||
Nitrous | |||
PCP | |||
Stimulants (caffeine, cocaine, speed, Adderal®, etc.) | |||
»Tilidine« (also known as Valoron®, Darby, generics) is a synthetic opioid that is commonly used and prescribed to treat severe to very severe pain. | |||
It is a prodrug that is metabolized in the body primarily in the liver by cytochrome P450 enzymes to its active metabolite nortilidine. | |||
“Tilidine” was patented in 1967 by the former German pharmaceutical manufacturer Gödecke and introduced to the market in 1970 as “Valoron®”. | |||
Nowadays, generics are also on the market, usually as a fixed combination with Naloxone (Narcan®, Naloxone + Brandname, Narcanti, Evzio) to reduce the risk of abuse. | |||
Effects: Pain relief, often euphoria, anesthesia | |||
Duration: | |||
Orally; Total time: 4-6 hours | |||
5 - 15 min: onset | |||
20 - 40 min: come up | |||
1 - 2 hours: Peak | |||
30 - 60 min: offset | |||
SIDE EFFECTS: | |||
Frequently: | |||
Nausea, vomiting, heavy sweating (especially when stopping), dizziness, tiredness, headache, nervousness, diarrhea, stomach pain | |||
Uncommon: sleepiness | |||
Not officially known: | |||
Hallucinations, confusion, euphoric mood, tremors, increased reflexes, muscle twitching | |||
❗ Danger of psychological and physical dependence | |||
❗Addiction: | |||
“Tilidin” is a weakly effective opioid that can become physically and psychologically addictive in a short period of time! | |||
❗Classic withdrawal symptoms are: | |||
- Heavy sweating | |||
- Depressive moods | |||
- Suicidal thoughts | |||
- general malaise | |||
- Strong desire for painkillers | |||
- Exhaustion | |||
- psychological pain | |||
- Headache | |||
- Pain in the body | |||
- Dizziness | |||
- nausea, | |||
- Vomiting | |||
- Gastrointestinal complaints | |||
- Inner unrest | |||
- Irritability | |||
- Tremble | |||
- heart racing | |||
Duration: | |||
Physical detoxification – usually a few days to two weeks | |||