Melatonin: Difference between revisions

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Melatonin is commonly used as a medication for insomnia; however, there is insufficient scientific evidence to prove any benefit in this area.<ref>{{cite book | vauthors=((Brasure, M.)), ((MacDonald, R.)), ((Fuchs, E.)), ((Olson, C. M.)), ((Carlyle, M.)), ((Diem, S.)), ((Koffel, E.)), ((Khawaja, I. S.)), ((Ouellette, J.)), ((Butler, M.)), ((Kane, R. L.)), ((Wilt, T. J.)) | date= 2015 | title=Management of Insomnia Disorder | publisher=Agency for Healthcare Research and Quality (US) | series=AHRQ Comparative Effectiveness Reviews | url=http://www.ncbi.nlm.nih.gov/books/NBK343503/}}</ref> It is sold over-the-counter in most pharmacies within the United States and Canada. In other countries, it may require a prescription or not be available.

It should be noted that when purchasing melatonin, dosages may range from 3 - 10mg. While not dangerous, this dosage range is well beyond the effective dose of .25 mg, and may increase instances of drowsiness the next day.<ref>{{cite journal | vauthors=((Mundey, K.)), ((Benloucif, S.)), ((Harsanyi, K.)), ((Dubocovich, M. L.)), ((Zee, P. C.)) | journal=Sleep | title=Phase-dependent treatment of delayed sleep phase syndrome with melatonin | volume=28 | issue=10 | pages=1271–1278 | date= October 2005 | issn=0161-8105 | doi=10.1093/sleep/28.10.1271}}</ref>

It should be noted that when purchasing melatonin, dosages may range from 3 - 10mg. While not dangerous, this dosage range is well beyond the effective dose of .25 mg, and may increase instances of drowsiness the next day.<ref>{{cite journal | vauthors=((Mundey, K.)), ((Benloucif, S.)), ((Harsanyi, K.)), ((Dubocovich, M. L.)), ((Zee, P. C.)) | journal=Sleep | title=Phase-dependent treatment of delayed sleep phase syndrome with melatonin | volume=28 | issue=10 | pages=1271–1278 | date= October 2005 | issn=0161-8105 | doi=10.1093/sleep/28.10.1271}}</ref> In the United States, some melatonin gummy supplements have varied from 74% to 374% of the stated amount.<ref>Cohen, P. A., Avula, B., Wang, Y., Katragunta, K., & Khan, I. (2023). Quantity of melatonin and CBD in melatonin gummies sold in the US. ''JAMA'', ''329''(16), 1401. [https://en.wikipedia.org/wiki/Digital_object_identifier doi]:[https://doi.org/10.1001/jama.2023.2296 10.1001/jama.2023.2296]. <br /></ref>

==Chemistry==

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 Melatonin is commonly used as a medication for insomnia; however, there is insufficient scientific evidence to prove any benefit in this area.<ref>{{cite book | vauthors=((Brasure, M.)), ((MacDonald, R.)), ((Fuchs, E.)), ((Olson, C. M.)), ((Carlyle, M.)), ((Diem, S.)), ((Koffel, E.)), ((Khawaja, I. S.)), ((Ouellette, J.)), ((Butler, M.)), ((Kane, R. L.)), ((Wilt, T. J.)) | date= 2015 | title=Management of Insomnia Disorder | publisher=Agency for Healthcare Research and Quality (US) | series=AHRQ Comparative Effectiveness Reviews | url=http://www.ncbi.nlm.nih.gov/books/NBK343503/}}</ref> It is sold over-the-counter in most pharmacies within the United States and Canada. In other countries, it may require a prescription or not be available.
-It should be noted that when purchasing melatonin, dosages may range from 3 - 10mg. While not dangerous, this dosage range is well beyond the effective dose of .25 mg, and may increase instances of drowsiness the next day.<ref>{{cite journal | vauthors=((Mundey, K.)), ((Benloucif, S.)), ((Harsanyi, K.)), ((Dubocovich, M. L.)), ((Zee, P. C.)) | journal=Sleep | title=Phase-dependent treatment of delayed sleep phase syndrome with melatonin | volume=28 | issue=10 | pages=1271–1278 | date= October 2005 | issn=0161-8105 | doi=10.1093/sleep/28.10.1271}}</ref>
+It should be noted that when purchasing melatonin, dosages may range from 3 - 10mg. While not dangerous, this dosage range is well beyond the effective dose of .25 mg, and may increase instances of drowsiness the next day.<ref>{{cite journal | vauthors=((Mundey, K.)), ((Benloucif, S.)), ((Harsanyi, K.)), ((Dubocovich, M. L.)), ((Zee, P. C.)) | journal=Sleep | title=Phase-dependent treatment of delayed sleep phase syndrome with melatonin | volume=28 | issue=10 | pages=1271–1278 | date= October 2005 | issn=0161-8105 | doi=10.1093/sleep/28.10.1271}}</ref> In the United States, some melatonin gummy supplements have varied from 74% to 374% of the stated amount.<ref>Cohen, P. A., Avula, B., Wang, Y., Katragunta, K., & Khan, I. (2023). Quantity of melatonin and CBD in melatonin gummies sold in the US. ''JAMA'', ''329''(16), 1401. [https://en.wikipedia.org/wiki/Digital_object_identifier doi]:[https://doi.org/10.1001/jama.2023.2296 10.1001/jama.2023.2296]. <br /></ref>
 ==Chemistry==