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Talk:Dextromethorphan: Difference between revisions
>Uzi →Dextromethorphan/Bupropion: Reply |
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On the other hand, [[Wikipedia:Dextromethorphan/bupropion|dextromethorphan/bupropion]] is an approved combination drug; each ''extended-release'' tablet contains 45 mg DXM and 105 mg bupropion. The maximum dose for depression is set at 2 tablets per day, spaced at least 8 hours apart.<ref name="p37859435">McCarthy, B; Bunn, H; Santalucia, M; Wilmouth, C; Muzyk, A; Smith, CM (30 November 2023). "Dextromethorphan-bupropion (Auvelity) for the Treatment of Major Depressive Disorder". Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. 21 (4): 609–616. doi:10.9758/cpn.23.1081. PMID 37859435. PMC [http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10591164/ 10591164]. Retrieved via PMC.</ref> Although this combination drug is safe enough to be approved, the safety of an instant-release combination and of higher doses remains a concern. | On the other hand, [[Wikipedia:Dextromethorphan/bupropion|dextromethorphan/bupropion]] is an approved combination drug; each ''extended-release'' tablet contains 45 mg DXM and 105 mg bupropion. The maximum dose for depression is set at 2 tablets per day, spaced at least 8 hours apart.<ref name="p37859435">McCarthy, B; Bunn, H; Santalucia, M; Wilmouth, C; Muzyk, A; Smith, CM (30 November 2023). "Dextromethorphan-bupropion (Auvelity) for the Treatment of Major Depressive Disorder". Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. 21 (4): 609–616. doi:10.9758/cpn.23.1081. PMID 37859435. PMC [http://www.ncbi.nlm.nih.gov/pmc/articles/pmc10591164/ 10591164]. Retrieved via PMC.</ref> Although this combination drug is safe enough to be approved, the safety of an instant-release combination and of higher doses remains a concern. | ||
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I fixed the error. I don't think [[User:Mnbvcxz]] meant to do that, their description is a minor edit that only fixes bolding and he reversed two different edits in one. [[User:Uzi|Uzi]] ([[User talk:Uzi|talk]]) 03:32, 8 June 2024 (UTC) | |||
So [[User:JH556|JH556]], I ''guess'' the relative safety has something to do with it being extended-release. I don't know how much safety margin goes into the "space doses at least 8hrs apart" disclaimer, but it has to be... decent enough? | So [[User:JH556|JH556]], I ''guess'' the relative safety has something to do with it being extended-release. I don't know how much safety margin goes into the "space doses at least 8hrs apart" disclaimer, but it has to be... decent enough? | ||