NEP: Difference between revisions

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As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP in humans. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.

~~== Potency of NEP crystals versus NEP Powder ==~~

Anecdotal evidence shows most recent bathes have a drastic difference in potency, especially the NEP Powder, which seems to have 50% potency over the crystals. Keep this in mind that 10mg insufflated when using Crystals has a drastically different effect from 10mg insufflated NEP Powder. It's recommended to limit yourself to 10mg insufflated per dose when using Crystal form. The powder form is generally considered the "mild" NEP. Some people prefer the "mild" version of the NEP crystals, since it will cause less heart strain and other side negative effects. It looks like the crystals don't seem to be simply crushed to powder. Rather an inactive or less active substance seems to added.which decreases potency by a lot. Even when you have a high tolerance you will notice the difference between the Crystals and Powder when insufflated. The smell of the crystals is also way more prominent and becomes an unpleasant odor. While the powder barely changes in smell, even after a year.

==Chemistry==

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==Subjective effects==

===Notice on Crystals vs Powder===

Anecdotal evidence shows most recent bathes have drastic difference in potency, especially the NEP Powder, which seems to have 50% potency over the crystals (''very batch dependent''). Keep in mind, that 10mg insufflated when using Crystals could've a drastic different effect from 10mg insufflated NEP Powder. It's recommended to limit yourself to 10mg insufflated per dose, when using the Crystal form<ref name=":1">[https://www.reddit.com/r/researchchemicals/comments/1alawbu/how_to_enjoy_your_shitty_nep_a_quick_guide/ Reddit - Explanation to use the noradrenergic NEP batch]</ref>. The powder form is generally considered the "mild" NEP. Some people prefer the "mild" version of the NEP crystals, since it will cause less heart strain and other negative physical side effects. It looks like the crystals don't seem to be simply crushed to powder. Either an inactive or less active substance seems to added, or another [[Enantiomers|enantiomer]] is found is this batch, which changes the [[Stimulation|stimulating]] effect by a lot{{citation needed}}. Even if

ou have a high tolerance, you will notice the difference between the Crystals and Powder when insufflated (also ''very batch dependent''). The smell of the crystals is also way more prominent and becomes an unpleasant odor. While the powder barely changes in smell, even after a year.

Additionally, it seems there're various batches of NEP Crystals, in different forms, even from the same seller/vendor, with different effects from each other.

One batch seems to have more noradrenergic effects, and fewer dopaminergic effects, which results in more physical side effects, and fewer cognitive effects.<ref name=":1" /> This batch contains "compressed" white crystals, while better batches, with more subjectively positive dopaminergic effects, seems to look like "uncompressed", transparent crystals, which can also be found in newer batches.{{citation needed}}

{{effects/base

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 As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP in humans. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.
-== Potency of NEP crystals versus NEP Powder ==
-Anecdotal evidence shows most recent bathes have a drastic difference in potency, especially the NEP Powder, which seems to have 50% potency over the crystals. Keep this in mind that 10mg insufflated when using Crystals has a drastically different effect from 10mg insufflated NEP Powder. It's recommended to limit yourself to 10mg insufflated per dose when using Crystal form. The powder form is generally considered the "mild" NEP. Some people prefer the "mild" version of the NEP crystals, since it will cause less heart strain and other side negative effects. It looks like the crystals don't seem to be simply crushed to powder. Rather an inactive or less active substance seems to added.which decreases potency by a lot. Even when you have a high tolerance you will notice the difference between the Crystals and Powder when insufflated. The smell of the crystals is also way more prominent and becomes an unpleasant odor. While the powder barely changes in smell, even after a year.
 ==Chemistry==
@@ Line 22: / Line 19: @@
 ==Subjective effects==
+===Notice on Crystals vs Powder===
+Anecdotal evidence shows most recent bathes have drastic difference in potency, especially the NEP Powder, which seems to have 50% potency over the crystals (''very batch dependent''). Keep in mind, that 10mg insufflated when using Crystals could've a drastic different effect from 10mg insufflated NEP Powder. It's recommended to limit yourself to 10mg insufflated per dose, when using the Crystal form<ref name=":1">[https://www.reddit.com/r/researchchemicals/comments/1alawbu/how_to_enjoy_your_shitty_nep_a_quick_guide/ Reddit - Explanation to use the noradrenergic NEP batch]</ref>. The powder form is generally considered the "mild" NEP. Some people prefer the "mild" version of the NEP crystals, since it will cause less heart strain and other negative physical side effects. It looks like the crystals don't seem to be simply crushed to powder. Either an inactive or less active substance seems to added, or another [[Enantiomers|enantiomer]] is found is this batch, which changes the [[Stimulation|stimulating]] effect by a lot{{citation needed}}. Even if
+ou have a high tolerance, you will notice the difference between the Crystals and Powder when insufflated (also ''very batch dependent''). The smell of the crystals is also way more prominent and becomes an unpleasant odor. While the powder barely changes in smell, even after a year.
+Additionally, it seems there're various batches of NEP Crystals, in different forms, even from the same seller/vendor, with different effects from each other.
+One batch seems to have more noradrenergic effects, and fewer dopaminergic effects, which results in more physical side effects, and fewer cognitive effects.<ref name=":1" /> This batch contains "compressed" white crystals, while better batches, with more subjectively positive dopaminergic effects, seems to look like "uncompressed", transparent crystals, which can also be found in newer batches.{{citation needed}}
 {{Preamble/SubjectiveEffects}}
 {{effects/base