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Cocoa: Difference between revisions
>David Hedlund →Dosage: m |
>David Hedlund →Pharmacology: caffeine abstinence |
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Theobromine has a half-life of 10 hours but over 16% may be unmodified 48 h after a single dose of 10 mg/Kg.<ref>{{cite journal |last1=Martínez-Pinilla |first1=E |last2=Oñatibia-Astibia |first2=A |last3=Franco |first3=R |title=The relevance of theobromine for the beneficial effects of cocoa consumption. |journal=Frontiers in pharmacology |date=2015 |volume=6 |pages=30 |doi=10.3389/fphar.2015.00030 |pmid=25750625 |pmc=4335269}}</ref> | Theobromine has a half-life of 10 hours but over 16% may be unmodified 48 h after a single dose of 10 mg/Kg.<ref>{{cite journal |last1=Martínez-Pinilla |first1=E |last2=Oñatibia-Astibia |first2=A |last3=Franco |first3=R |title=The relevance of theobromine for the beneficial effects of cocoa consumption. |journal=Frontiers in pharmacology |date=2015 |volume=6 |pages=30 |doi=10.3389/fphar.2015.00030 |pmid=25750625 |pmc=4335269}}</ref> | ||
It may take 4-8 weeks of caffeine abstinence to reset tolerance in regular users.<ref>{{cite journal |last1=Cappelletti |first1=S |last2=Piacentino |first2=D |last3=Sani |first3=G |last4=Aromatario |first4=M |title=Caffeine: cognitive and physical performance enhancer or psychoactive drug? |journal=Current neuropharmacology |date=January 2015 |volume=13 |issue=1 |pages=71-88 |doi=10.2174/1570159X13666141210215655 |pmid=26074744 |pmc=4462044}}</ref> | |||
==Subjective effects== | ==Subjective effects== | ||