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Mirtazapine: Difference between revisions
>Theacidman m Mirtazapine is not an inverse agonist. An inverse agonist reverses site activity, and antagonists block the site from being activated. |
>Jkadosh15 m Added its relation to other substances in its class when having the potential to cause RLS |
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==Pharmacology== | ==Pharmacology== | ||
Mirtazapine acts as an [[antagonist]] upon the following receptors:<ref name="Fernandez2005">{{cite journal | vauthors=((Fernández, J.)), ((Alonso, J. M.)), ((Andrés, J. I.)), ((Cid, J. M.)), ((Díaz, A.)), ((Iturrino, L.)), ((Gil, P.)), ((Megens, A.)), ((Sipido, V. K.)), ((Trabanco, A. A.)) | journal=Journal of Medicinal Chemistry | title=Discovery of New Tetracyclic Tetrahydrofuran Derivatives as Potential Broad-Spectrum Psychotropic Agents | volume=48 | issue=6 | pages=1709–1712 | date=1 March 2005 | url=https://pubs.acs.org/doi/10.1021/jm049632c | issn=0022-2623 | doi=10.1021/jm049632c}}</ref><ref>{{cite journal | vauthors=((Boer, Th. de)), ((Maura, G.)), ((Raiteri, M.)), ((Vos, C. J. de)), ((Wieringa, J.)), ((Pinder, R. M.)) | journal=Neuropharmacology | title=Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers | volume=27 | issue=4 | pages=399–408 | date=1 April 1988 | url=https://www.sciencedirect.com/science/article/pii/0028390888901499 | issn=0028-3908 | doi=10.1016/0028-3908(88)90149-9}}</ref> | Mirtazapine acts as an [[antagonist]]/inverse agonist upon the following receptors:<ref name="Fernandez2005">{{cite journal | vauthors=((Fernández, J.)), ((Alonso, J. M.)), ((Andrés, J. I.)), ((Cid, J. M.)), ((Díaz, A.)), ((Iturrino, L.)), ((Gil, P.)), ((Megens, A.)), ((Sipido, V. K.)), ((Trabanco, A. A.)) | journal=Journal of Medicinal Chemistry | title=Discovery of New Tetracyclic Tetrahydrofuran Derivatives as Potential Broad-Spectrum Psychotropic Agents | volume=48 | issue=6 | pages=1709–1712 | date=1 March 2005 | url=https://pubs.acs.org/doi/10.1021/jm049632c | issn=0022-2623 | doi=10.1021/jm049632c}}</ref><ref>{{cite journal | vauthors=((Boer, Th. de)), ((Maura, G.)), ((Raiteri, M.)), ((Vos, C. J. de)), ((Wieringa, J.)), ((Pinder, R. M.)) | journal=Neuropharmacology | title=Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, org 3770 and its enantiomers | volume=27 | issue=4 | pages=399–408 | date=1 April 1988 | url=https://www.sciencedirect.com/science/article/pii/0028390888901499 | issn=0028-3908 | doi=10.1016/0028-3908(88)90149-9}}</ref> | ||
*[[serotonin|5-HT<sub>2A</sub> receptor]]<ref name="Fernandez2005" /> | *[[serotonin|5-HT<sub>2A</sub> receptor]]<ref name="Fernandez2005" /> | ||
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{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||
{{effects/base | {{effects/base | ||
|{{effects/physical| | |{{effects/physical| | ||
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*'''[[Effect::Bronchodilation]]''' - This can cause swallowing to be extremely difficult and uncomfortable, as with some other [[deliriants|anticholinergics]] such as [[diphenhydramine]]. As with [[diphenhydramine]], it is most prominent during the onset phase of the experience and often fades away as the peak sets in. | *'''[[Effect::Bronchodilation]]''' - This can cause swallowing to be extremely difficult and uncomfortable, as with some other [[deliriants|anticholinergics]] such as [[diphenhydramine]]. As with [[diphenhydramine]], it is most prominent during the onset phase of the experience and often fades away as the peak sets in. | ||
*'''[[Effect::Muscle relaxation]]''' | *'''[[Effect::Muscle relaxation]]''' | ||
*'''[[Effect::Restless legs]]''' - This effect is considered slightly less apparent than it is with [[diphenhydramine]]. | *'''[[Effect::Restless legs]]''' - This effect is considered slightly less apparent than it is with [[diphenhydramine]] but more apparent than other atypical antidepressants like Trazadone or Doxepin. | ||
*'''[[Effect::Nausea suppression]]''' | *'''[[Effect::Nausea suppression]]''' | ||
}} | }} | ||