1,4-Butanediol: Difference between revisions

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'''1,4-Butanediol''' (also known as '''1,4-B''', '''BDO''', '''BD or 1,4-BD''') is a [[psychoactive class::depressant]] substance and a [[prodrug]] for [[GHB]]. It occurs as a thick, colorless liquid or solid depending on storage temperature (melting point of 16 ℃), and has a distinct bitter-sweet taste.<ref>{{Citation | vauthors=PubChem | title=1,4-Butanediol | url=https://pubchem.ncbi.nlm.nih.gov/compound/8064}}</ref> It is used as a recreational intoxicant with effects similar to [[alcohol]] and [[GHB]].<ref>{{cite journal | vauthors=((Zvosec, D. L.)), ((Smith, S. W.)), ((McCutcheon, J. R.)), ((Spillane, J.)), ((Hall, B. J.)), ((Peacock, E. A.)) | journal=New England Journal of Medicine | title=Adverse Events, Including Death, Associated with the Use of 1,4-Butanediol | volume=344 | issue=2 | pages=87–94 | date=11 January 2001 | url=https://doi.org/10.1056/NEJM200101113440202 | issn=0028-4793 | doi=10.1056/NEJM200101113440202}}</ref> 1 ml of 1,4-butanediol is equivalent to 1.4 g of Na-GHB.

'''1,4-Butanediol''' (also known as '''1,4-B''', '''BDO''', '''BD or 1,4-BD''') is a [[psychoactive class::depressant]] substance and a [[prodrug]] for [[GHB]]. It occurs as a thick, colorless liquid or solid depending on storage temperature (melting point of 20 ℃), and has a distinct bitter-sweet taste.<ref>{{Citation | vauthors=PubChem | title=1,4-Butanediol | url=https://pubchem.ncbi.nlm.nih.gov/compound/8064}}</ref> It is used as a recreational intoxicant with effects similar to [[alcohol]] and [[GHB]].<ref>{{cite journal | vauthors=((Zvosec, D. L.)), ((Smith, S. W.)), ((McCutcheon, J. R.)), ((Spillane, J.)), ((Hall, B. J.)), ((Peacock, E. A.)) | journal=New England Journal of Medicine | title=Adverse Events, Including Death, Associated with the Use of 1,4-Butanediol | volume=344 | issue=2 | pages=87–94 | date=11 January 2001 | url=https://doi.org/10.1056/NEJM200101113440202 | issn=0028-4793 | doi=10.1056/NEJM200101113440202}}</ref> 1 ml of 1,4-butanediol is equivalent to 1.4 g of Na-GHB.

1,4-Butanediol is used industrially as a solvent and in the manufacture of some types of plastics, elastic fibers and polyurethanes. In organic chemistry, it is used for the synthesis of [[GBL|γ-butyrolactone (GBL)]].<ref>{{cite journal | vauthors=((Zhao, J.)), ((Hartwig, J. F.)) | journal=Organometallics | title=Acceptorless, Neat, Ruthenium-Catalyzed Dehydrogenative Cyclization of Diols to Lactones | volume=24 | issue=10 | pages=2441–2446 | date=1 May 2005 | url=https://pubs.acs.org/doi/10.1021/om048983m | issn=0276-7333 | doi=10.1021/om048983m}}</ref>

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 {{SubstanceBox/1,4-Butanediol}}
-'''1,4-Butanediol''' (also known as '''1,4-B''', '''BDO''', '''BD or 1,4-BD''') is a [[psychoactive class::depressant]] substance and a [[prodrug]] for [[GHB]]. It occurs as a thick, colorless liquid or solid depending on storage temperature (melting point of 16 ℃), and has a distinct bitter-sweet taste.<ref>{{Citation | vauthors=PubChem | title=1,4-Butanediol | url=https://pubchem.ncbi.nlm.nih.gov/compound/8064}}</ref> It is used as a recreational intoxicant with effects similar to [[alcohol]] and [[GHB]].<ref>{{cite journal | vauthors=((Zvosec, D. L.)), ((Smith, S. W.)), ((McCutcheon, J. R.)), ((Spillane, J.)), ((Hall, B. J.)), ((Peacock, E. A.)) | journal=New England Journal of Medicine | title=Adverse Events, Including Death, Associated with the Use of 1,4-Butanediol | volume=344 | issue=2 | pages=87–94 | date=11 January 2001 | url=https://doi.org/10.1056/NEJM200101113440202 | issn=0028-4793 | doi=10.1056/NEJM200101113440202}}</ref> 1 ml of 1,4-butanediol is equivalent to 1.4 g of Na-GHB.
+'''1,4-Butanediol''' (also known as '''1,4-B''', '''BDO''', '''BD or 1,4-BD''') is a [[psychoactive class::depressant]] substance and a [[prodrug]] for [[GHB]]. It occurs as a thick, colorless liquid or solid depending on storage temperature (melting point of 20 ℃), and has a distinct bitter-sweet taste.<ref>{{Citation | vauthors=PubChem | title=1,4-Butanediol | url=https://pubchem.ncbi.nlm.nih.gov/compound/8064}}</ref> It is used as a recreational intoxicant with effects similar to [[alcohol]] and [[GHB]].<ref>{{cite journal | vauthors=((Zvosec, D. L.)), ((Smith, S. W.)), ((McCutcheon, J. R.)), ((Spillane, J.)), ((Hall, B. J.)), ((Peacock, E. A.)) | journal=New England Journal of Medicine | title=Adverse Events, Including Death, Associated with the Use of 1,4-Butanediol | volume=344 | issue=2 | pages=87–94 | date=11 January 2001 | url=https://doi.org/10.1056/NEJM200101113440202 | issn=0028-4793 | doi=10.1056/NEJM200101113440202}}</ref> 1 ml of 1,4-butanediol is equivalent to 1.4 g of Na-GHB.
 ,4-Butanediol is used industrially as a solvent and in the manufacture of some types of plastics, elastic fibers and polyurethanes. In organic chemistry, it is used for the synthesis of [[GBL|γ-butyrolactone (GBL)]].<ref>{{cite journal | vauthors=((Zhao, J.)), ((Hartwig, J. F.)) | journal=Organometallics | title=Acceptorless, Neat, Ruthenium-Catalyzed Dehydrogenative Cyclization of Diols to Lactones | volume=24 | issue=10 | pages=2441–2446 | date=1 May 2005 | url=https://pubs.acs.org/doi/10.1021/om048983m | issn=0276-7333 | doi=10.1021/om048983m}}</ref>