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Progesterone: Difference between revisions
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==Pharmacology== | ==Pharmacology== | ||
{{pharmacology}} | {{pharmacology}} | ||
Progesterone on it's own acts as a [[antagonist]] on the '''σ<sub>2</sub>''' receptor and as a [[wikipedia:negative allosteric modulator|negative allosteric modulator]] on [[wikipedia:nicotinic acetylcholine receptors|nicotinic acetylcholine receptors]]. However most of the psychoactive effects of progesterone are induced by it's metabolites.<ref name="Gonzalez 2020 p. 1846">{{cite journal | last=Gonzalez | first=Susana Laura | title=Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule | journal=Neural Regeneration Research | volume=15 | issue=10 | date=2020 | issn=1673-5374 | pmid=32246629 | pmc=7513974 | doi=10.4103/1673-5374.280314 | doi-access=free | page=1846}}</ref> | Progesterone on it's own acts as a [[antagonist]] on the [[wikipedia:Sigma-2 receptor|'''σ<sub>2</sub>''' receptor]] and as a [[wikipedia:negative allosteric modulator|negative allosteric modulator]] on [[wikipedia:nicotinic acetylcholine receptors|nicotinic acetylcholine receptors]]. However most of the psychoactive effects of progesterone are induced by it's metabolites.<ref name="Gonzalez 2020 p. 1846">{{cite journal | last=Gonzalez | first=Susana Laura | title=Progesterone for the treatment of central nervous system disorders: the many signaling roads for a single molecule | journal=Neural Regeneration Research | volume=15 | issue=10 | date=2020 | issn=1673-5374 | pmid=32246629 | pmc=7513974 | doi=10.4103/1673-5374.280314 | doi-access=free | page=1846}}</ref> | ||
===Metabolism=== | ===Metabolism=== | ||
Progesterone is mainly metabolised in the liver, therefore the route of administration significantly influences the intensity of experienced effects. The most important metabolites are [[wikipedia:allopregnanolone|allopregnanolone]], [[wikipedia:pregnanolone|pregnanolone]], [[wikipedia:isopregnanolone|isopregnanolone]] and [[wikipedia:epipregnanolone|epipregnanolone]].<ref name="Kolatorova Vitku Suchopar Hill 2022 p. 7989">{{cite journal | last=Kolatorova | first=Lucie | last2=Vitku | first2=Jana | last3=Suchopar | first3=Josef | last4=Hill | first4=Martin | last5=Parizek | first5=Antonin | title=Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine | journal=International Journal of Molecular Sciences | volume=23 | issue=14 | date=2022-07-20 | issn=1422-0067 | pmid=35887338 | doi=10.3390/ijms23147989 | doi-access=free | page=7989}}</ref> | Progesterone is mainly metabolised in the liver, therefore the route of administration significantly influences the intensity of experienced effects. The most important metabolites are [[wikipedia:allopregnanolone|allopregnanolone]], [[wikipedia:pregnanolone|pregnanolone]], [[wikipedia:isopregnanolone|isopregnanolone]] and [[wikipedia:epipregnanolone|epipregnanolone]].<ref name="Kolatorova Vitku Suchopar Hill 2022 p. 7989">{{cite journal | last=Kolatorova | first=Lucie | last2=Vitku | first2=Jana | last3=Suchopar | first3=Josef | last4=Hill | first4=Martin | last5=Parizek | first5=Antonin | title=Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine | journal=International Journal of Molecular Sciences | volume=23 | issue=14 | date=2022-07-20 | issn=1422-0067 | pmid=35887338 | doi=10.3390/ijms23147989 | doi-access=free | page=7989}}</ref> | ||