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Opioids: Difference between revisions
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====='''Mu (μ)'''===== | ====='''Mu (μ)'''===== | ||
The mu receptor is responsible for [[analgesia]], physical dependence, [[respiratory depression]], [[euphoria]], and possible [[vasodilation]].<ref name="receptors" /> | The mu receptor is responsible for [[analgesia]], physical dependence, [[respiratory depression]], [[euphoria]], and possible [[vasodilation]].<ref name="receptors" /> | ||
Agonists of mu opioid receptors produce sedative, euphoric, and anxiolytic effects largely through the interaction of the mu receptors with serotonin, dopamine, and norepinephrine. Activation of mu receptors allows for the disinhibition of serotonin and dopamine neurons by blocking the inhibitory effects of GABA on serotonin and dopamine neurons, thus increasing activity and release of serotonin and dopamine.<ref>https://www.sciencedirect.com/science/article/abs/pii/S1043661818306145</ref> Mu receptors additionally inhibit the activity of norepinephrine neurons, leading to sedation, anxiolysis, and respiratory depression.<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3274960/</ref> | |||
====='''Nociceptin'''===== | ====='''Nociceptin'''===== | ||