Lisdexamfetamine: Difference between revisions

Line 3:

'''Lisdexamfetamine''' (also known as '''lisdextroamphetamine''', '''L-lysine-dextroamphetamine''', or '''lisdexamfetamine dimesylate''' when under the brand names '''Elvanse''', '''Tyvense''', and '''Vyvanse''') is a [[psychoactive class::stimulant]] substance of the [[amphetamines|amphetamine class]]. It is a [https://en.wikipedia.org/wiki/Codrug codrug] for [[dextroamphetamine]] that is approved for the treatment of attention deficit hyperactivity disorder (ADHD) and moderate to severe binge-eating disorder.<ref>https://www.drugs.com/pro/vyvanse.html</ref> Like [[amphetamine]], lisdexamfetamine produces its effects by promoting the release of [[neurotransmitters]] [[dopamine]] and [[norepinephrine]] in the brain.

[[Subjective effects]] are essentially identical to that of [[dextroamphetamine]] except with a slower onset and a longer duration. These include [[stimulation]] (in a small percent of the population ~~paradoxal~~ [[sedation]]), [[focus enhancement]], [[motivation enhancement]], [[euphoria]]~~, and in a smaller population~~ . However, unlike [[dextroamphetamine]], lisdexamfetamine was specifically designed to prevent non-oral forms of administration (marketed as an anti-abuse design). This means that [[insufflation]], [[Route of administration#Smoked|smoking]] or [[Route of administration#Injection|injection]] do not provide faster absorption or onset. It is sometimes sold and used illicitly as a "study drug" as well as a recreational substance.

[[Subjective effects]] are essentially identical to that of [[dextroamphetamine]] except, with a slower onset and a longer duration. These include [[stimulation]] (in a small percent of the population. paradoxical [[sedation]]), [[focus enhancement]], [[motivation enhancement]], and [[euphoria]]. However, unlike [[dextroamphetamine]], lisdexamfetamine was specifically designed to prevent non-oral forms of administration (marketed as an anti-abuse design). This means that [[insufflation]], [[Route of administration#Smoked|smoking]] or [[Route of administration#Injection|injection]] do not provide faster absorption or onset. It is sometimes sold and used illicitly as a "study drug," as well as a recreational substance.

Despite the marketed anti-abuse design, many users report that lisdexamfetamine is capable of producing dependence and addiction like other [[euphoria]] inducing [[stimulants]], particularly when it is taken above the recommended dosage. As a result, it is highly advised to use [[harm reduction practices]] if using this substance.

Despite the marketed anti-abuse design, many users report that lisdexamfetamine is capable of producing dependence and addiction like other [[euphoria]]-inducing [[stimulants]], particularly when it is taken above the recommended dosage. As a result, it is highly advised to use [[harm reduction practices]] if using this substance.

==History and culture==

Line 34:

==Subjective effects==

While the subjective effects are almost identical to ~~that~~ of [[amphetamine]], lisdexamfetamine is significantly longer in its duration and more consistent in its intensity due to the slow release metabolism. Although this drug is rate-limited in its metabolism, sufficiently high doses are comparable to its instant release counterparts once the peak has been reached.

While the subjective effects are almost identical to those of [[amphetamine]], lisdexamfetamine is significantly longer in its duration and more consistent in its intensity due to the slow-release metabolism. Although this drug is rate-limited in its metabolism, sufficiently high doses are comparable to its instant-release counterparts once the peak has been reached.

Peripheral effects (such as increased heart rate and higher body temperature) are reported to be less prominent than formulations that partly contain [[levoamphetamine]], such as Adderall or the [[racemic]] [[amphetamine]] sulphate sold illicitly.

@@ Line 3: / Line 3: @@
 '''Lisdexamfetamine''' (also known as '''lisdextroamphetamine''', '''L-lysine-dextroamphetamine''', or '''lisdexamfetamine dimesylate''' when under the brand names '''Elvanse''', '''Tyvense''', and '''Vyvanse''') is a [[psychoactive class::stimulant]] substance of the [[amphetamines|amphetamine class]]. It is a [https://en.wikipedia.org/wiki/Codrug codrug] for [[dextroamphetamine]] that is approved for the treatment of attention deficit hyperactivity disorder (ADHD) and moderate to severe binge-eating disorder.<ref>https://www.drugs.com/pro/vyvanse.html</ref> Like [[amphetamine]], lisdexamfetamine produces its effects by promoting the release of [[neurotransmitters]] [[dopamine]] and [[norepinephrine]] in the brain.
-[[Subjective effects]] are essentially identical to that of [[dextroamphetamine]] except with a slower onset and a longer duration. These include [[stimulation]] (in a small percent of the population paradoxal [[sedation]]), [[focus enhancement]], [[motivation enhancement]], [[euphoria]], and in a smaller population . However, unlike [[dextroamphetamine]], lisdexamfetamine was specifically designed to prevent non-oral forms of administration (marketed as an anti-abuse design). This means that [[insufflation]], [[Route of administration#Smoked|smoking]] or [[Route of administration#Injection|injection]] do not provide faster absorption or onset. It is sometimes sold and used illicitly as a "study drug" as well as a recreational substance.
+[[Subjective effects]] are essentially identical to that of [[dextroamphetamine]] except, with a slower onset and a longer duration. These include [[stimulation]] (in a small percent of the population. paradoxical [[sedation]]), [[focus enhancement]], [[motivation enhancement]], and [[euphoria]]. However, unlike [[dextroamphetamine]], lisdexamfetamine was specifically designed to prevent non-oral forms of administration (marketed as an anti-abuse design). This means that [[insufflation]], [[Route of administration#Smoked|smoking]] or [[Route of administration#Injection|injection]] do not provide faster absorption or onset. It is sometimes sold and used illicitly as a "study drug," as well as a recreational substance.
-Despite the marketed anti-abuse design, many users report that lisdexamfetamine is capable of producing dependence and addiction like other [[euphoria]] inducing [[stimulants]], particularly when it is taken above the recommended dosage. As a result, it is highly advised to use [[harm reduction practices]] if using this substance.
+Despite the marketed anti-abuse design, many users report that lisdexamfetamine is capable of producing dependence and addiction like other [[euphoria]]-inducing [[stimulants]], particularly when it is taken above the recommended dosage. As a result, it is highly advised to use [[harm reduction practices]] if using this substance.
 ==History and culture==
@@ Line 34: / Line 34: @@
 ==Subjective effects==
-While the subjective effects are almost identical to that of [[amphetamine]], lisdexamfetamine is significantly longer in its duration and more consistent in its intensity due to the slow release metabolism. Although this drug is rate-limited in its metabolism, sufficiently high doses are comparable to its instant release counterparts once the peak has been reached.
+While the subjective effects are almost identical to those of [[amphetamine]], lisdexamfetamine is significantly longer in its duration and more consistent in its intensity due to the slow-release metabolism. Although this drug is rate-limited in its metabolism, sufficiently high doses are comparable to its instant-release counterparts once the peak has been reached.
 Peripheral effects (such as increased heart rate and higher body temperature) are reported to be less prominent than formulations that partly contain [[levoamphetamine]], such as Adderall or the [[racemic]] [[amphetamine]] sulphate sold illicitly.