Methcathinone: Difference between revisions

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==~~==How to Dose Properly==~~==

==Toxicity and harm potencial==

~~Methcathinone, due to its nature, can often cause extreme compulsive redosing~~. ~~A good strategy is to pre-plan your experience in advance~~.

===Neuro toxicity===

~~To minimalize the risk of compulsive redosing and severe negative effects, follow the below points~~:

Illicit methcathinone manufactured using potassium permanganate oxidation of [[ephedrine]] or [[pseudoephedrine]] has been connected with neurotoxicity caused by [https://en.wikipedia.org/wiki/Manganese manganese] poisoning.<ref>https://www.nejm.org/doi/full/10.1056/NEJMoa072488</ref>

* Pre-plan the total amount of Methcathinone ~~you will take. Limit the amount you have accessible~~ to ~~that amount.~~

===Dependence and abuse potential===

* Make a rough timeline of the experience. Plan how many re-doses you will do and when you will re-dose.

Methcathinone, due to its highly addictive nature, can often cause extreme [[compulsive redosing]].

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

===How to Dose Properly===.

It is recommended to plan the total amount of Methcathinone you will take beforehand, how many times you are planning to redose and limit the amount you have accessible accordingly, to minimalize the risk of [[compulsive redosing]].

~~From personal experience, I have discovered a way~~ to ~~use Methcathinone which works best for me:~~

Some people may also advice to tapper the comedown of a high dose, with a low dose after approximately an hour.

~~# Take a strong or heavy dose and redose twice. This is done by taking a first dose of 250-500mg (T:00:00). Afterwards you take~~ the ~~a redose, which is 40-50% the amount~~ of ~~the first dose (T:00:30-00:40). Which is then followed by~~ a ~~final re-dose, which is 40-50% of the first~~ dose ~~(T:01:15-01:45). ~~

~~# Take multiple common doses. Take 150-200mg~~, ~~then redose when it wears off~~ with ~~the same dose. Do a maximum of four doses. When you take~~ a dosage of Methcathinone, per say 350mg, you have to redose 25 mins later as a 40-50% of the first dose.So you don't comedown. Its really worth to redose once since actually it will be only a 45 min ride and the 4 hours comedown hell. Gradually decreasing the dose instead aka a redose will make it a ton more manageable. You can then redose another 40% or leave it. But '''don't''' redose more than twice.

~~In order to minimize the unpleasant effects during comedown, I would recommend to take 20% of your first~~ dose after ~~1h since your last previous redose.~~

~~Then you should stop.That's the best method to not have a huge comedown~~.~~ ~~

==Synthesis==

Methcathinone is synthesised most easily by reacting Pseudoephedrine with ~~KMnO4~~. The reaction is ~~very specific though. A very specific temperature~~ needs to be ~~achieved, below zero~~, so that the oxidation is subtle and not too energetic, ~~so that it does not destroy the~~ Pseudoephedrine ~~and make it~~ into Benzaldehyde. The same goes for the amount of ~~KMnO4~~, it has to be a specific ratio of oxidizer to Pseudoephedrine.

Methcathinone is synthesised most easily by reacting Pseudoephedrine with potassium permanganate, although dichromate may also be used as a oxidizer. The reaction is quite unstable and needs to be held at specifically -15 Celsious, so that the oxidation is subtle and not too energetic, turning Pseudoephedrine into Benzaldehyde. The same goes for the amount of potassium permanganate, it has to be a specific ratio of oxidizer to Pseudoephedrine.

[[File:synth.png|~~1740px~~]]

[[File:synth.png|800px]]

==See also==

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*[[3-MMC]] (''3-methylmethcathinone'')

*[[Ethcathinone]]

*[[Pseudoephidrine]]

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==References==

~~<references />https://bluelight.org/xf/members/joey.390415/~~

~~https://bluelight.org/xf/threads/what-was-the-first-research-chemical-that-you-tried-and-when.908924/post-15617257~~

[[Category:Psychoactive substance]]

[[Category:Cathinone]]

[[Category:Stimulant]]

@@ Line 68: / Line 68: @@
 }}
-====How to Dose Properly====
+==Toxicity and harm potencial==
-Methcathinone, due to its nature, can often cause extreme compulsive redosing. A good strategy is to pre-plan your experience in advance.<br>
+===Neuro toxicity===
-To minimalize the risk of compulsive redosing and severe negative effects, follow the below points:<br>
+Illicit methcathinone manufactured using potassium permanganate oxidation of [[ephedrine]] or [[pseudoephedrine]] has been connected with neurotoxicity caused by [https://en.wikipedia.org/wiki/Manganese manganese] poisoning.<ref>https://www.nejm.org/doi/full/10.1056/NEJMoa072488</ref>
-* Pre-plan the total amount of Methcathinone you will take. Limit the amount you have accessible to that amount.
+===Dependence and abuse potential===
-* Make a rough timeline of the experience. Plan how many re-doses you will do and when you will re-dose.
+Methcathinone, due to its highly addictive nature, can often cause extreme [[compulsive redosing]].
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
+===How to Dose Properly===.
+It is recommended to plan the total amount of Methcathinone you will take beforehand, how many times you are planning to redose and limit the amount you have accessible accordingly, to minimalize the risk of [[compulsive redosing]].
-From personal experience, I have discovered a way to use Methcathinone which works best for me:
+Some people may also advice to tapper the comedown of a high dose, with a low dose after approximately an hour.
-# Take a strong or heavy dose and redose twice. This is done by taking a first dose of 250-500mg (T:00:00).<br> Afterwards you take the a redose, which is 40-50% the amount of the first dose (T:00:30-00:40).<br>Which is then followed by a final re-dose, which is 40-50% of the first dose (T:01:15-01:45).<br>
-# Take multiple common doses. Take 150-200mg, then redose when it wears off with the same dose. Do a maximum of four doses.<br> When you take a dosage of Methcathinone, per say 350mg, you have to redose 25 mins later as a 40-50% of the first dose.So you don't comedown.<br> Its really worth to redose once since actually it will be only a 45 min ride and the 4 hours comedown hell.<br> Gradually decreasing the dose instead aka a redose will make it a ton more manageable. You can then redose another 40% or leave it.<br> But '''don't''' redose more than twice.<br>
-In order to minimize the unpleasant effects during comedown, I would recommend to take 20% of your first dose after 1h since your last previous redose.
-Then you should stop.That's the best method to not have a huge comedown.<br>
 ==Synthesis==
-Methcathinone is synthesised most easily by reacting Pseudoephedrine with KMnO4. The reaction is very specific though. A very specific temperature needs to be achieved, below zero, so that the oxidation is subtle and not too energetic, so that it does not destroy the Pseudoephedrine and make it into Benzaldehyde. The same goes for the amount of KMnO4, it has to be a specific ratio of oxidizer to Pseudoephedrine.
+Methcathinone is synthesised most easily by reacting Pseudoephedrine with potassium permanganate, although dichromate may also be used as a oxidizer. The reaction is quite unstable and needs to be held at specifically -15 Celsious, so that the oxidation is subtle and not too energetic, turning Pseudoephedrine into Benzaldehyde. The same goes for the amount of potassium permanganate, it has to be a specific ratio of oxidizer to Pseudoephedrine.
-[[File:synth.png|1740px]]
+[[File:synth.png|800px]]
 ==See also==
@@ Line 107: / Line 99: @@
 *[[3-MMC]] (''3-methylmethcathinone'')
 *[[Ethcathinone]]
+*[[Pseudoephidrine]]
@@ Line 125: / Line 118: @@
 ==References==
-<references />https://bluelight.org/xf/members/joey.390415/
+{{reflist|2}}
-https://bluelight.org/xf/threads/what-was-the-first-research-chemical-that-you-tried-and-when.908924/post-15617257
 [[Category:Psychoactive substance]]
 [[Category:Cathinone]]
 [[Category:Stimulant]]