Serotonergic psychedelic: Difference between revisions
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The cortico-striato-thalamo-cortical loops (also known as CSTC-loops) appear to be central to the function of psychedelics,<ref>Taylor, S. B., Lewis, C. R., & Olive, M. F. (2013). The neurocircuitry of illicit psychostimulant addiction: acute and chronic effects in humans. Substance Abuse and Rehabilitation, 4, 29–43. https://doi.org/10.2147/SAR.S39684; [..] The overall output of the basal ganglia is predominantly via the thalamus, which then projects back to the PFC to form cortico-striatal-thalamo-cortical (CSTC) loops. [..]</ref> which are also regulated by the serotonergic system. These control loops connect brain areas like the frontal lobe, the striatum and the thalamus; they aggregate, process and forward internal and external information. | The cortico-striato-thalamo-cortical loops (also known as CSTC-loops) appear to be central to the function of psychedelics,<ref>Taylor, S. B., Lewis, C. R., & Olive, M. F. (2013). The neurocircuitry of illicit psychostimulant addiction: acute and chronic effects in humans. Substance Abuse and Rehabilitation, 4, 29–43. https://doi.org/10.2147/SAR.S39684; [..] The overall output of the basal ganglia is predominantly via the thalamus, which then projects back to the PFC to form cortico-striatal-thalamo-cortical (CSTC) loops. [..]</ref> which are also regulated by the serotonergic system. These control loops connect brain areas like the frontal lobe, the striatum and the thalamus; they aggregate, process and forward internal and external information. | ||
The disruption of the neurotransmitter balance causes these control loops to collapse overwhelmed, leading to the flooding of the frontal lobe with neuronal excitatory glutamate; internal and external stimuli as well as all kinds of non-conscious contents can freely move up to the cerebral cortex and appear as visions in consciousness.<ref>Vollenweider, F. X. (2001). Brain mechanisms of hallucinogens and entactogens. Dialogues in Clinical Neuroscience, 3(4), 265–79. Retrieved from | The disruption of the neurotransmitter balance causes these control loops to collapse overwhelmed, leading to the flooding of the frontal lobe with neuronal excitatory glutamate; internal and external stimuli as well as all kinds of non-conscious contents can freely move up to the cerebral cortex and appear as visions in consciousness.<ref>Vollenweider, F. X. (2001). Brain mechanisms of hallucinogens and entactogens. Dialogues in Clinical Neuroscience, 3(4), 265–79. Retrieved from https://doi.org/10.31887%2FDCNS.2001.3.4%2Ffxvollenweider</ref><ref>[http://archive.today/jcBm Edelrausch im Labor] – ''Neuro Culture Lab'' (German)</ref> | ||
Furthermore, over-activation of the ''locus coeruleus'' and subsequent widespread [[norepinephrine]] secretion may occur, causing a perceived state of sensory transcendence and sometimes even intense spiritual or [[transpersonal]] experiences. | Furthermore, over-activation of the ''locus coeruleus'' and subsequent widespread [[norepinephrine]] secretion may occur, causing a perceived state of sensory transcendence and sometimes even intense spiritual or [[transpersonal]] experiences. | ||
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==Examples== | ==Examples== | ||
<div class= | <div class="flex-panel"> | ||
<div class= | <div class="flex-column"> | ||
<div class="panel radius"> | <div class="panel radius"> | ||
<h3 class="panel-header">[[Lysergamides]][[File:book.svg|x20px|right|link=]]</h3> | <h3 class="panel-header">[[Lysergamides]][[File:book.svg|x20px|right|link=]]</h3> | ||
<ul class="featured-table"> | <ul class="featured-table"> | ||
<li class="featured list-item"> | <li class="featured list-item"> | ||
* [[1B-LSD]] | *[[1B-LSD]] | ||
* [[1P-ETH-LAD]] | *[[1P-ETH-LAD]] | ||
* [[1P-LSD]] | *[[1P-LSD]] | ||
* [[AL-LAD]] | *[[AL-LAD]] | ||
* [[ALD-52]] | *[[ALD-52]] | ||
* [[ETH-LAD]] | *[[ETH-LAD]] | ||
* [[LSA]] | *[[LSA]] | ||
* [[LSD]] | *[[LSD]] | ||
* [[LSM-775]] | *[[LSM-775]] | ||
* [[LSZ]] | *[[LSZ]] | ||
* [[MIPLA]] | *[[MIPLA]] | ||
* [[PARGY-LAD]] | *[[PARGY-LAD]] | ||
* [[PRO-LAD]] | *[[PRO-LAD]] | ||
</li> | </li> | ||
</ul> | </ul> | ||
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<li class="featured list-item"> | <li class="featured list-item"> | ||
<h4 class="media-heading">[[Base Tryptamines]]</h4> | <h4 class="media-heading">[[Base Tryptamines]]</h4> | ||
* [[DET]] | *[[DET]] | ||
* [[DiPT]] | *[[DiPT]] | ||
* [[DMT]] | *[[DMT]] | ||
* [[DPT]] | *[[DPT]] | ||
* [[EiPT]] | *[[EiPT]] | ||
* [[EPT]] | *[[EPT]] | ||
* [[MET]] | *[[MET]] | ||
* [[MiPT]] | *[[MiPT]] | ||
* [[MPT]] | *[[MPT]] | ||
* [[PiPT]] | *[[PiPT]] | ||
* [[αMT]] | *[[αMT]] | ||
</li> | </li> | ||
<li class="featured list-item"> | <li class="featured list-item"> | ||
<h4 class="media-heading">[[Substituted Tryptamines]]</h4> | <h4 class="media-heading">[[Substituted Tryptamines]]</h4> | ||
* [[4-PO-DMT]] (''Psilocybin'') | *[[4-PO-DMT]] (''Psilocybin'') | ||
* [[4-HO-DMT]] (''Psilocin'') | *[[4-HO-DMT]] (''Psilocin'') | ||
* [[4-HO-MET]] (''Metocin'') | *[[4-HO-MET]] (''Metocin'') | ||
* [[4-HO-DET]] (''Ethocin'') | *[[4-HO-DET]] (''Ethocin'') | ||
* [[4-HO-MiPT]] (''Miprocin'') | *[[4-HO-MiPT]] (''Miprocin'') | ||
* [[4-HO-DiPT]] (''Iprocin'') | *[[4-HO-DiPT]] (''Iprocin'') | ||
* [[4-HO-MPT]] | *[[4-HO-MPT]] | ||
* [[4-HO-EPT]] | *[[4-HO-EPT]] | ||
* [[4-HO-DPT]] | *[[4-HO-DPT]] | ||
* [[4-AcO-DMT]] (''Psilacetin'') | *[[4-AcO-DMT]] (''Psilacetin'') | ||
* [[4-AcO-MET]] (''Metacetin'', ''Azomet'') | *[[4-AcO-MET]] (''Metacetin'', ''Azomet'') | ||
* [[4-AcO-DET]] (''Ethacetin'') | *[[4-AcO-DET]] (''Ethacetin'') | ||
* [[4-AcO-MiPT]] (''Mipracetin'') | *[[4-AcO-MiPT]] (''Mipracetin'') | ||
* [[4-AcO-DiPT]] (''Ipracetin'') | *[[4-AcO-DiPT]] (''Ipracetin'') | ||
* [[4-AcO-MPT]] | *[[4-AcO-MPT]] | ||
* [[4-AcO-EPT]] | *[[4-AcO-EPT]] | ||
* [[4-AcO-DPT]] | *[[4-AcO-DPT]] | ||
* [[5-HO-DMT]] (''Bufotenin'') | *[[5-HO-DMT]] (''Bufotenin'') | ||
* [[5-MeO-DMT]] | *[[5-MeO-DMT]] | ||
* [[5-MeO-MiPT]] (''Moxy'') | *[[5-MeO-MiPT]] (''Moxy'') | ||
* [[5-MeO-DiPT]] (''Foxy'') | *[[5-MeO-DiPT]] (''Foxy'') | ||
* [[5-MeO-DALT]] | *[[5-MeO-DALT]] | ||
* [[5-MeO-MALT]] | *[[5-MeO-MALT]] | ||
* [[Ibogaine]] | *[[Ibogaine]] | ||
</li> | </li> | ||
</ul> | </ul> | ||
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</div> | </div> | ||
<div class= | <div class="flex-column"> | ||
<div class="panel radius"> | <div class="panel radius"> | ||
<h3 class="panel-header">[[Phenethylamines]] [[File:flask.svg|x20px|right|link=]]</h3> | <h3 class="panel-header">[[Phenethylamines]] [[File:flask.svg|x20px|right|link=]]</h3> | ||
<ul class="featured-table"> | <ul class="featured-table"> | ||
<li class="featured list-item"> | <li class="featured list-item"> | ||
* [[Mescaline]] | *[[Mescaline]] | ||
* [[Escaline]] | *[[Escaline]] | ||
* [[Allylescaline]] | *[[Allylescaline]] | ||
* [[Methallylescaline]] | *[[Methallylescaline]] | ||
* [[Proscaline]] | *[[Proscaline]] | ||
</li> | </li> | ||
<li class="featured list-item"> | <li class="featured list-item"> | ||
<h4 class="media-heading">[[2C-x]] series</h4> | <h4 class="media-heading">[[2C-x]] series</h4> | ||
* [[2C-B]] | *[[2C-B]] | ||
* [[2C-C]] | *[[2C-C]] | ||
* [[2C-D]] | *[[2C-D]] | ||
* [[2C-E]] | *[[2C-E]] | ||
* [[2C-H]] | *[[2C-H]] | ||
* [[2C-I]] | *[[2C-I]] | ||
* [[2C-P]] | *[[2C-P]] | ||
* [[2C-TFM]] | *[[2C-TFM]] | ||
* [[2C-T-2]] | *[[2C-T-2]] | ||
* [[2C-T-7]] | *[[2C-T-7]] | ||
</li> | </li> | ||
<li class="featured list-item"> | <li class="featured list-item"> | ||
<h4 class="media-heading">[[DOx]] series</h4> | <h4 class="media-heading">[[DOx]] series</h4> | ||
* [[DOB]] | *[[DOB]] | ||
* [[DOC]] | *[[DOC]] | ||
* [[DOET]] (''DOE'') | *[[DOET]] (''DOE'') | ||
* [[DOI]] | *[[DOI]] | ||
* [[DOM]] | *[[DOM]] | ||
* [[DOPR]] | *[[DOPR]] | ||
</li> | </li> | ||
<li class="featured list-item"> | <li class="featured list-item"> | ||
<h4 class="media-heading">[[25x-NBOMe]]s</h4> | <h4 class="media-heading">[[25x-NBOMe]]s</h4> | ||
* [[25B-NBOMe]] | *[[25B-NBOMe]] | ||
* [[25C-NBOMe]] | *[[25C-NBOMe]] | ||
* [[25D-NBOMe]] | *[[25D-NBOMe]] | ||
* [[25I-NBOMe]] | *[[25I-NBOMe]] | ||
* [[25N-NBOMe]] | *[[25N-NBOMe]] | ||
</li> | </li> | ||
<li class="featured list-item"> | <li class="featured list-item"> | ||
<h4 class="media-heading">Others</h4> | <h4 class="media-heading">Others</h4> | ||
* [[2C-B-FLY]] | *[[2C-B-FLY]] | ||
* [[Bromo-DragonFLY]] | *[[Bromo-DragonFLY]] | ||
* [[ßk-2C-B]] | *[[ßk-2C-B]] | ||
* [[TMA-2]] | *[[TMA-2]] | ||
* [[TMA-6]] | *[[TMA-6]] | ||
</ul> | </ul> | ||
</div> | </div> | ||
</div> | </div> | ||
<div class= | <div class="flex-column"> | ||
<div class="panel radius"> | <div class="panel radius"> | ||
<h3 class="panel-header">[[Entheogens]] [[File:users.svg|x20px|right|link=]]</h3> | <h3 class="panel-header">[[Entheogens]] [[File:users.svg|x20px|right|link=]]</h3> | ||
<ul class="featured-table"> | <ul class="featured-table"> | ||
<li class="featured list-item"> | <li class="featured list-item"> | ||
* [[Acacia confusa]] | *[[Acacia confusa]] | ||
* [[Ayahuasca]] | *[[Ayahuasca]] | ||
* [[Hawaiian baby woodrose]] | *[[Hawaiian baby woodrose]] | ||
* [[Iboga]] | *[[Iboga]] | ||
* [[Mimosa hostilis]] | *[[Mimosa hostilis]] | ||
* [[Morning glory]] | *[[Morning glory]] | ||
* [[Psilocybin mushrooms]] | *[[Psilocybin mushrooms]] | ||
* [[Yopo]] | *[[Yopo]] | ||
</li> | </li> | ||
</ul> | </ul> | ||
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<ul class="featured-table"> | <ul class="featured-table"> | ||
<li class="featured list-item"> | <li class="featured list-item"> | ||
* [[5-MeO-DiBF]] | *[[5-MeO-DiBF]] | ||
* [[Efavirenz]] | *[[Efavirenz]] | ||
</li> | </li> | ||
</ul> | </ul> | ||
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==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Serotonin]] | *[[Serotonin]] | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/Serotonergic_psychedelic Serotonergic psychedelic (Wikipedia)] | *[https://en.wikipedia.org/wiki/Serotonergic_psychedelic Serotonergic psychedelic (Wikipedia)] | ||
==Literature== | ==Literature== | ||
* {{cite journal|last1=Nichols|first1=D. E.|title=Psychedelics|journal=Pharmacological Reviews|volume=68|issue=2|year=2016|pages=264–355|issn=1521-0081|doi=10.1124/pr.115.011478}} | |||
* {{cite journal|last1=Geyer|first1=M.A.|last2=Nichols|first2=D.E.|last3=Vollenweider|first3=F.X.|title=Serotonin-Related Psychedelic Drugs|year=2009|pages=731–738|doi=10.1016/B978-008045046-9.01160-8}} | *{{cite journal|last1=Nichols|first1=D. E.|title=Psychedelics|journal=Pharmacological Reviews|volume=68|issue=2|year=2016|pages=264–355|issn=1521-0081|doi=10.1124/pr.115.011478}} | ||
* Nichols, C. D., & Sanders-Bush, E. (2001). "Serotonin Receptor Signaling and Hallucinogenic Drug Action". Heffter Rev Psychedelic Res, 2, 73-79. https://web-beta.archive.org/web/20170110205041/https://heffter.org/docs/hrireview/02/chap5.pdf | *{{cite journal|last1=Geyer|first1=M.A.|last2=Nichols|first2=D.E.|last3=Vollenweider|first3=F.X.|title=Serotonin-Related Psychedelic Drugs|year=2009|pages=731–738|doi=10.1016/B978-008045046-9.01160-8}} | ||
* {{cite journal|last1=Halberstadt|first1=Adam L.|title=Recent advances in the neuropsychopharmacology of serotonergic hallucinogens|journal=Behavioural Brain Research|volume=277|year=2015|pages=99–120|issn=01664328|doi=10.1016/j.bbr.2014.07.016}} | *Nichols, C. D., & Sanders-Bush, E. (2001). "Serotonin Receptor Signaling and Hallucinogenic Drug Action". Heffter Rev Psychedelic Res, 2, 73-79. https://web-beta.archive.org/web/20170110205041/https://heffter.org/docs/hrireview/02/chap5.pdf | ||
* {{cite journal|last1=Beique|first1=J.-C.|last2=Imad|first2=M.|last3=Mladenovic|first3=L.|last4=Gingrich|first4=J. A.|last5=Andrade|first5=R.|title=Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex|journal=Proceedings of the National Academy of Sciences|volume=104|issue=23|year=2007|pages=9870–9875|issn=0027-8424|doi=10.1073/pnas.0700436104}} | *{{cite journal|last1=Halberstadt|first1=Adam L.|title=Recent advances in the neuropsychopharmacology of serotonergic hallucinogens|journal=Behavioural Brain Research|volume=277|year=2015|pages=99–120|issn=01664328|doi=10.1016/j.bbr.2014.07.016}} | ||
* {{cite journal|last1=Winter|first1=J.C|last2=Fiorella|first2=D.J|last3=Timineri|first3=D.M|last4=Filipink|first4=R.A|last5=Helsley|first5=S.E|last6=Rabin|first6=R.A|title=Serotonergic Receptor Subtypes and Hallucinogen-Induced Stimulus Control|journal=Pharmacology Biochemistry and Behavior|volume=64|issue=2|year=1999|pages=283–293|issn=00913057|doi=10.1016/S0091-3057(99)00063-5}} | *{{cite journal|last1=Beique|first1=J.-C.|last2=Imad|first2=M.|last3=Mladenovic|first3=L.|last4=Gingrich|first4=J. A.|last5=Andrade|first5=R.|title=Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex|journal=Proceedings of the National Academy of Sciences|volume=104|issue=23|year=2007|pages=9870–9875|issn=0027-8424|doi=10.1073/pnas.0700436104}} | ||
* {{cite journal|last1=Nichols|first1=David E.|last2=Nichols|first2=Charles D.|title=Serotonin Receptors|journal=Chemical Reviews|volume=108|issue=5|year=2008|pages=1614–1641|issn=0009-2665|doi=10.1021/cr078224o}} | *{{cite journal|last1=Winter|first1=J.C|last2=Fiorella|first2=D.J|last3=Timineri|first3=D.M|last4=Filipink|first4=R.A|last5=Helsley|first5=S.E|last6=Rabin|first6=R.A|title=Serotonergic Receptor Subtypes and Hallucinogen-Induced Stimulus Control|journal=Pharmacology Biochemistry and Behavior|volume=64|issue=2|year=1999|pages=283–293|issn=00913057|doi=10.1016/S0091-3057(99)00063-5}} | ||
* Canal, C. E., & Murnane, K. S. (2017). The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens. Journal of Psychopharmacology, 31(1), 127-143. https://doi.org/10.1177/0269881116677104 | *{{cite journal|last1=Nichols|first1=David E.|last2=Nichols|first2=Charles D.|title=Serotonin Receptors|journal=Chemical Reviews|volume=108|issue=5|year=2008|pages=1614–1641|issn=0009-2665|doi=10.1021/cr078224o}} | ||
*Canal, C. E., & Murnane, K. S. (2017). The serotonin 5-HT2C receptor and the non-addictive nature of classic hallucinogens. Journal of Psychopharmacology, 31(1), 127-143. https://doi.org/10.1177/0269881116677104 | |||
==References== | ==References== | ||
<references/> | <references /> | ||
[[Category:Psychedelic]] | [[Category:Psychedelic]] |