F-Phenibut: Difference between revisions

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'''F-Phenibut''' (also known as '''4-Fluorophenibut''', '''Fluorophenibut''', '''Fluorobut''', '''~~Baflofen~~''' and '''CGP-11130''') is a central nervous system [[psychoactive class::depressant]] and closely related structural analog of [[phenibut]]. F-Phenibut possesses an effect profile similar to [[phenibut]] but with a faster [[onset]], significantly increased potency, and shorter [[duration|total duration]].{{citation needed}} It has recently become available through online [[research chemical]] vendors, although little is known about this substance, particularly [[Research chemicals#Toxicity and harm potential|its potential toxicity]] and addiction potential.

'''F-Phenibut''' (also known as '''4-Fluorophenibut''', '''Fluorophenibut''', '''Fluorobut''', '''Baclofen''' and '''CGP-11130''') is a central nervous system [[psychoactive class::depressant]] and closely related structural analog of [[phenibut]]. F-Phenibut possesses an effect profile similar to [[phenibut]] but with a faster [[onset]], significantly increased potency, and shorter [[duration|total duration]].{{citation needed}} It has recently become available through online [[research chemical]] vendors, although little is known about this substance, particularly [[Research chemicals#Toxicity and harm potential|its potential toxicity]] and addiction potential.

The substance can be classified as a [[GABApentinoid |gabapentinoid]], a class which contains other substances such as [[gabapentin]], [[pregabalin]]<ref>{{cite book | vauthors=((Wyllie, E.)), ((Cascino, G. D.)), ((Gidal, B. E.)), ((Goodkin, H. P.)) | date=17 February 2012 | title=Wyllie’s Treatment of Epilepsy: Principles and Practice | publisher=Lippincott Williams & Wilkins | isbn=9781451153484}}</ref>, [[baclofen]], and [https://en.wikipedia.org/wiki/Gamma-Amino-beta-hydroxybutyric_acid GABOB].<ref name="one">{{cite journal | vauthors=((Lapin, I.)) | journal=CNS Drug Reviews | title=Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug | volume=7 | issue=4 | pages=471–481 | date=7 June 2006 | url=https://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x | issn=1080563X | doi=10.1111/j.1527-3458.2001.tb00211.x}}</ref><ref>{{cite book | vauthors=((Benzon, H.)), ((Rathmell, J. P.)), ((Wu, C. L.)), ((Turk, D.)), ((Argoff, C. E.)), ((Hurley, R. W.)) | date=11 September 2013 | title=Practical Management of Pain E-Book | publisher=Elsevier Health Sciences | isbn=9780323170802}}</ref> It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid ([[GABA]]), with an addition of a phenyl ring that allows it to cross the blood–brain barrier.<ref name="one" />

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 {{SubstanceBox/F-Phenibut}}
-'''F-Phenibut''' (also known as '''4-Fluorophenibut''', '''Fluorophenibut''', '''Fluorobut''', '''Baflofen''' and '''CGP-11130''') is a central nervous system [[psychoactive class::depressant]] and closely related structural analog of [[phenibut]]. F-Phenibut possesses an effect profile similar to [[phenibut]] but with a faster [[onset]], significantly increased potency, and shorter [[duration|total duration]].{{citation needed}} It has recently become available through online [[research chemical]] vendors, although little is known about this substance, particularly [[Research chemicals#Toxicity and harm potential|its potential toxicity]] and addiction potential.
+'''F-Phenibut''' (also known as '''4-Fluorophenibut''', '''Fluorophenibut''', '''Fluorobut''', '''Baclofen''' and '''CGP-11130''') is a central nervous system [[psychoactive class::depressant]] and closely related structural analog of [[phenibut]]. F-Phenibut possesses an effect profile similar to [[phenibut]] but with a faster [[onset]], significantly increased potency, and shorter [[duration|total duration]].{{citation needed}} It has recently become available through online [[research chemical]] vendors, although little is known about this substance, particularly [[Research chemicals#Toxicity and harm potential|its potential toxicity]] and addiction potential.
 The substance can be classified as a [[GABApentinoid |gabapentinoid]], a class which contains other substances such as [[gabapentin]], [[pregabalin]]<ref>{{cite book | vauthors=((Wyllie, E.)), ((Cascino, G. D.)), ((Gidal, B. E.)), ((Goodkin, H. P.)) | date=17 February 2012 | title=Wyllie’s Treatment of Epilepsy: Principles and Practice | publisher=Lippincott Williams & Wilkins | isbn=9781451153484}}</ref>, [[baclofen]], and [https://en.wikipedia.org/wiki/Gamma-Amino-beta-hydroxybutyric_acid GABOB].<ref name="one">{{cite journal | vauthors=((Lapin, I.)) | journal=CNS Drug Reviews | title=Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug | volume=7 | issue=4 | pages=471–481 | date=7 June 2006 | url=https://onlinelibrary.wiley.com/doi/10.1111/j.1527-3458.2001.tb00211.x | issn=1080563X | doi=10.1111/j.1527-3458.2001.tb00211.x}}</ref><ref>{{cite book | vauthors=((Benzon, H.)), ((Rathmell, J. P.)), ((Wu, C. L.)), ((Turk, D.)), ((Argoff, C. E.)), ((Hurley, R. W.)) | date=11 September 2013 | title=Practical Management of Pain E-Book | publisher=Elsevier Health Sciences | isbn=9780323170802}}</ref> It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid ([[GABA]]), with an addition of a phenyl ring that allows it to cross the blood–brain barrier.<ref name="one" />