Talk:Dextromethorphan: Difference between revisions

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Dextromethorphan now can be obtained in a combination medication known as Auvelity in the US. It is perscription only, however, the interaction between dextromethorphan and bupropion seems to potentiate the antidepressant effects of dextromethorphan and bupropion together. Just a thought though, maybe include it at the bottom, near interactions?

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This combination of DXM and Bupropion surprises me, given Bupropion has deliriant-like effects through antagonism of the nicotinic acetylcholine receptors. If a page about it is made, for harm reduction purposes there needs to be significant warning about the dysphoric, nauseating, and especially seizure inducing properties which become an extreme danger at high dosages; since Auvelity contains 45mg of DXM & 105mg of Bupropion per tablet, if someone took 3 tablets they would be at 315mg of Bupropion which is just 10mg away from the danger-threshold of Bupropion @325mg. Taking more than three tablets of Auvelity would be extremely dangerous, and three tablets would be rather dangerous. If a page about Auvelity is made, then this needs to be mentioned for safety reasons.

--[[User:JH556|JH556]] ([[User talk:JH556|talk]]) 20:24, 13 July 2023 (UTC)

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 Dextromethorphan now can be obtained in a combination medication known as Auvelity in the US. It is perscription only, however, the interaction between dextromethorphan and bupropion seems to potentiate the antidepressant effects of dextromethorphan and bupropion together. Just a thought though, maybe include it at the bottom, near interactions?
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+This combination of DXM and Bupropion surprises me, given Bupropion has deliriant-like effects through antagonism of the nicotinic acetylcholine receptors. If a page about it is made, for harm reduction purposes there needs to be significant warning about the dysphoric, nauseating, and especially seizure inducing properties which become an extreme danger at high dosages; since Auvelity contains 45mg of DXM & 105mg of Bupropion per tablet, if someone took 3 tablets they would be at 315mg of Bupropion which is just 10mg away from the danger-threshold of Bupropion @325mg. Taking more than three tablets of Auvelity would be extremely dangerous, and three tablets would be rather dangerous. If a page about Auvelity is made, then this needs to be mentioned for safety reasons.
+--[[User:JH556|JH556]] ([[User talk:JH556|talk]]) 20:24, 13 July 2023 (UTC)