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2M2B: Difference between revisions
>Psychemist Fleshed out a bit more of subjective effects with respect to the familiar alcohol, for harm reduction purposes. |
>ScumOfTheEarth2828 No edit summary |
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==Pharmacology== | ==Pharmacology== | ||
2-Methyl-2-butanol inhibits binding to a proconvulsant site on the [[GABA]] [[receptor]]<ref>{{cite journal | vauthors=((Martin, J. V.)), ((Bilgin, N. M.)), ((Iba, M. M.)) | journal=Toxicology Letters | title=Influence of oxygenated fuel additives and their metabolites on the binding of a convulsant ligand of the gamma-aminobutyric acid(A) (GABA(A)) receptor in rat brain membrane preparations | volume=129 | issue=3 | pages=219–226 | date=28 March 2002 | issn=0378-4274 | doi=10.1016/s0378-4274(02)00020-6}}</ref> which causes negatively charged chloride ions to enter neurons and increase the amount of excitation necessary to cause the neurons to fire. As it is a tertiary alcohol, it cannot be metabolized by alcohol dehydrogenase into aldehydes (which cause the hangover associated with consuming large amounts of [[ethanol]]). This makes 2M2B significantly safer than primary alcohols.<ref>http://www.mhhe.com/physsci/chemistry/carey/student/olc/ch15oxidationalcohols.html</ref> However, a consequence of this is that 2-methyl-2-butanol has an extended duration of action with effects | 2-Methyl-2-butanol inhibits binding to a proconvulsant site on the [[GABA]] [[receptor]]<ref>{{cite journal | vauthors=((Martin, J. V.)), ((Bilgin, N. M.)), ((Iba, M. M.)) | journal=Toxicology Letters | title=Influence of oxygenated fuel additives and their metabolites on the binding of a convulsant ligand of the gamma-aminobutyric acid(A) (GABA(A)) receptor in rat brain membrane preparations | volume=129 | issue=3 | pages=219–226 | date=28 March 2002 | issn=0378-4274 | doi=10.1016/s0378-4274(02)00020-6}}</ref> which causes negatively charged chloride ions to enter neurons and increase the amount of excitation necessary to cause the neurons to fire. As it is a tertiary alcohol, it cannot be metabolized by alcohol dehydrogenase into aldehydes (which cause the hangover associated with consuming large amounts of [[ethanol]]). This makes 2M2B significantly safer than primary alcohols.<ref>http://www.mhhe.com/physsci/chemistry/carey/student/olc/ch15oxidationalcohols.html</ref> However, a consequence of this is that 2-methyl-2-butanol has an extended duration of action with effects that last up to 12 hours after its consumption. | ||
==Subjective effects== | ==Subjective effects== | ||
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*'''[[Effect::Sedation]]''' - In comparison to [[alcohol]], 2-methyl-2-butanol is significantly more sedating. On low to moderate doses, one may feel a lack of energy, resulting in extreme difficulty in performing basic tasks. This effect can last up to 24 hours afterwards. | *'''[[Effect::Sedation]]''' - In comparison to [[alcohol]], 2-methyl-2-butanol is significantly more sedating. On low to moderate doses, one may feel a lack of energy, resulting in extreme difficulty in performing basic tasks. This effect can last up to 24 hours afterwards. | ||
*'''[[Effect::Muscle relaxation]]''' | *'''[[Effect::Muscle relaxation]]''' | ||
*'''[[Effect::Physical euphoria]]''' - | *'''[[Effect::Physical euphoria]]''' - In comparison to [[alcohol]], 2-methyl-2-butanol has less pronounced physical euphoria in proportion to other effects. | ||
*'''[[Effect::Motor control loss]]''' - | *'''[[Effect::Motor control loss]]''' - In comparison to [[alcohol]], 2-methyl-2-butanol is significantly more impairing to motor control in proportion to other effects. | ||
*'''[[Effect::Appetite enhancement]]''' | *'''[[Effect::Appetite enhancement]]''' | ||
*'''[[Effect::Dizziness]]''' | *'''[[Effect::Dizziness]]''' | ||