This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Methamphetamine: Difference between revisions
>Aiueo aaaa Add alias name |
>PsyLinuz added emergency treatment with benzodiazepine under overdose |
||
| Line 163: | Line 163: | ||
===Overdose=== | ===Overdose=== | ||
A methamphetamine overdose may result in a wide range of symptoms and is potentially fatal at heavy dosages.<ref>"Desoxyn Prescribing Information" | http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/005378s028lbl.pdf</ref> A moderate overdose of methamphetamine may induce symptoms such as abnormal heart rhythm, confusion, dysuria, high or low blood pressure, hyperthermia, hyperreflexia, myalgia, severe agitation, tachypnea, tremor, urinary hesitancy, and urinary retention.<ref>{{cite book | veditors=((Goodman, L. S.)), ((Brunton, L. L.)), ((Chabner, B.)), ((Knollmann, B. C.)) | date= 2011 | title=Goodman & Gilman’s pharmacological basis of therapeutics | publisher=McGraw-Hill | edition=12th ed | isbn=9780071624428}}</ref> An extremely large overdose may produce symptoms such as adrenergic storm, methamphetamine psychosis, anuria, cardiogenic shock, cerebral hemorrhage, circulatory collapse, hyperpyrexia, pulmonary hypertension, renal failure, rhabdomyolysis, [[serotonin syndrome]], and a form of stereotypy ("tweaking"). A methamphetamine overdose will likely also result in mild brain damage due to dopaminergic and serotonergic neurotoxicity.<ref name="Nestler2009" /><ref name="Krasnova2009" /> Death from fatal methamphetamine poisoning is typically preceded by convulsions and coma.<ref>"Desoxyn Prescribing Information" | http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/005378s028lbl.pdf</ref> | A methamphetamine overdose may result in a wide range of symptoms and is potentially fatal at heavy dosages.<ref>"Desoxyn Prescribing Information" | http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/005378s028lbl.pdf</ref> A moderate overdose of methamphetamine may induce symptoms such as abnormal heart rhythm, confusion, dysuria, high or low blood pressure, hyperthermia, hyperreflexia, myalgia, severe agitation, tachypnea, tremor, urinary hesitancy, and urinary retention.<ref>{{cite book | veditors=((Goodman, L. S.)), ((Brunton, L. L.)), ((Chabner, B.)), ((Knollmann, B. C.)) | date= 2011 | title=Goodman & Gilman’s pharmacological basis of therapeutics | publisher=McGraw-Hill | edition=12th ed | isbn=9780071624428}}</ref> An extremely large overdose may produce symptoms such as adrenergic storm, methamphetamine psychosis, anuria, cardiogenic shock, cerebral hemorrhage, circulatory collapse, hyperpyrexia, pulmonary hypertension, renal failure, rhabdomyolysis, [[serotonin syndrome]], and a form of stereotypy ("tweaking"). A methamphetamine overdose will likely also result in mild brain damage due to dopaminergic and serotonergic neurotoxicity.<ref name="Nestler2009" /><ref name="Krasnova2009" /> Death from fatal methamphetamine poisoning is typically preceded by convulsions and coma.<ref>"Desoxyn Prescribing Information" | http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/005378s028lbl.pdf</ref> | ||
====Emergency treatment==== | |||
Acute methamphetamine overdose is largely managed by treating the symptoms, and administration of [[benzodiazepine]]s relieves symptoms such as agitation, hypertension, tachycardia, and seizure.<ref>{{cite journal|journal=Clinical Toxicology|title=The clinical toxicology of metamfetamine|vauthors=((Robin, S.)), ((Michael, B.))|url=https://www.tandfonline.com/doi/full/10.3109/15563650.2010.516752|doi=10.3109/15563650.2010.516752|volume=48|year=2010|issue=7|page=676}}</ref> | |||
===Harm reduction=== | ===Harm reduction=== | ||