Safer injection guide: Difference between revisions
>David Hedlund Distilled water is often sold as battery water, but since it's not designed for medical use, it may lack specifications and may be unsafe to inject. |
>David Hedlund →Sterile water for injection: copied a table `Pharmacopoeia specifications for water for injection` from https://en.wikipedia.org/wiki/Ultrapure_water#Applications_in_pharmaceutical_industry |
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'''Sterile [https://en.wikipedia.org/wiki/Water_for_injection water for injection]''' is used to create solutions that will be administered by injection. Water for injection is generally made by distillation or reverse osmosis.<ref>https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018632s051lbl.pdf</ref><ref name=Gh2004>{{cite book|last1=Ghosh|first1=Tapash K.|last2=Jasti|first2=Bhaskara R.|title=Theory and Practice of Contemporary Pharmaceutics|date=2004|publisher=CRC Press|isbn=9780203644478|page=396|url=https://books.google.com/books?id=whiC7aSFLY8C&pg=PA396|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170116162803/https://books.google.ca/books?id=whiC7aSFLY8C&pg=PA396|archivedate=2017-01-16}}</ref> Water for injection can also be used for [[Nasal spray guide|nasal sprays]], and eye drops. | '''Sterile [https://en.wikipedia.org/wiki/Water_for_injection water for injection]''' is used to create solutions that will be administered by injection. Water for injection is generally made by distillation or reverse osmosis.<ref>https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018632s051lbl.pdf</ref><ref name=Gh2004>{{cite book|last1=Ghosh|first1=Tapash K.|last2=Jasti|first2=Bhaskara R.|title=Theory and Practice of Contemporary Pharmaceutics|date=2004|publisher=CRC Press|isbn=9780203644478|page=396|url=https://books.google.com/books?id=whiC7aSFLY8C&pg=PA396|language=en|url-status=live|archiveurl=https://web.archive.org/web/20170116162803/https://books.google.ca/books?id=whiC7aSFLY8C&pg=PA396|archivedate=2017-01-16}}</ref> Water for injection can also be used for [[Nasal spray guide|nasal sprays]], and eye drops. | ||
'''Pharmacopoeia specifications for water for injection'''<br /> | |||
{| class="wikitable sortable" | |||
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! Properties !! [[European Pharmacopoeia|European Pharmacopoeia (Ph.Eur.)]]<ref>{{cite book|title=European Pharmacopoeia|date=2013|publisher=Council of Europe|location=Strasbourg, France|isbn=978-92-871-7531-1|pages=3555–3558|edition=8|language=English|chapter=Water for injections}}</ref> !! [[United States Pharmacopeia|United States Pharmacopeia (USP)]]<ref>{{cite book|title=United States Pharmacopeia and the National Formulary (USP-NF)|date=October 2014|publisher=U.S. Pharmacopeial Convention|location=Rockville, MD, USA|page=5805|edition=USP38–NF33|chapter=USP Monographs: Water for Injection}}</ref> | |||
|- | |||
| Conductivity<ref group=upper-alpha>If in-line conductivity exceeds values additional testing is required before a conclusion can be made. Refer to the respective pharmacopoeia for details.</ref> || <1.3 μS/cm at 25 °C||<1.3 μS/cm at 25 °C | |||
|- | |||
| [[Total organic carbon|Total Organic Carbon]] (TOC) || <0.5 mg/L || <0.50 mg/L | |||
|- | |||
| Bacteria (guideline) || <10 [[Colony-forming unit|CFU]]/100 mL || <10 [[Colony-forming unit|CFU]]/100 mL | |||
|- | |||
| Endotoxin || <0.25 IU/mL || <0.25 EU/mL <ref group=upper-alpha>One USP Endotoxin Unit (EU) is equal to one International Unit (IU) of endotoxin</ref> | |||
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| Nitrates || <0.2 ppm || N/A | |||
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| Aluminium || <10 ppb || N/A | |||
|} | |||
* [https://en.wikipedia.org/wiki/Eye_drop Eye drops] | * [https://en.wikipedia.org/wiki/Eye_drop Eye drops] |