Unique substance warnings: Difference between revisions

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===Genotype===

* [[MDMA]]: A small percentage ~~(1-10% depending on~~ race & family history~~) are "slow metabolizers"~~, ~~who~~ have ~~low levels~~ of a liver enzyme (P450 2D6~~) which metabolizes many drugs, including MDMA (as well as Prozac, DXM, and many other pharmaceuticals)~~. ~~These people may~~ be more sensitive to MDMA, ~~might require~~ lower doses, and should be ~~cautious~~.<ref>http://www.erowid.org/chemicals/mdma/mdma_basics.shtml</ref>

* [[MDMA]]: There is a small percentage of people, who due to their race and family history, have a lower level of the liver enzyme P450 2D6. This can cause them to be more sensitive to MDMA, requiring lower doses and extra caution should be taken.<ref>http://www.erowid.org/chemicals/mdma/mdma_basics.shtml</ref>

* [[THC]]: ''CYP2C9'' genotype affects THC sensitivity significantly: ''Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.''<ref>https://www.ncbi.nlm.nih.gov/books/NBK564166/</ref>

==References==

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 ===Genotype===
-* [[MDMA]]: A small percentage (1-10% depending on race & family history) are "slow metabolizers", who have low levels of a liver enzyme (P450 2D6) which metabolizes many drugs, including MDMA (as well as Prozac, DXM, and many other pharmaceuticals). These people may be more sensitive to MDMA, might require lower doses, and should be cautious.<ref>http://www.erowid.org/chemicals/mdma/mdma_basics.shtml</ref>
+* [[MDMA]]: There is a small percentage of people, who due to their race and family history, have a lower level of the liver enzyme P450 2D6. This can cause them to be more sensitive to MDMA, requiring lower doses and extra caution should be taken.<ref>http://www.erowid.org/chemicals/mdma/mdma_basics.shtml</ref>
 * [[THC]]: ''CYP2C9'' genotype affects THC sensitivity significantly: ''Subjects with the *3/*3 genotype had 3-fold higher THC levels in their blood than subjects with the *1/*1 genotype. Those subjects with one copy of each gene (*1/*3) had intermediate THC levels that were about 2-fold higher than subjects with *1/*1.''<ref>https://www.ncbi.nlm.nih.gov/books/NBK564166/</ref>
 ==References==
 {{reflist}}