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Harmala alkaloid: Difference between revisions
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==Chemistry== | ==Chemistry== | ||
Harmala alkaloids are substituted derivatives of the molecule [[beta-Carbolines|''beta''-carboline]]. The structure of''beta''-carboline is comprised of an indole skeleton fused to a pyridine ring. Harmine, harmaline, and tetrahydroharmine share structural substitutions and they all contain a methoxy group at R<sub>7</sub> and a methyl group at R<sub>1</sub>. They differ in the saturation of their six-member nitrogenous ring. Harmine contains an unsaturated pyridine ring while harmaline contains a dihydrogenated pyridine ring. Tetrahydroharmine is saturated with four additional hydrogen bonds than harmine. | Harmala alkaloids are substituted derivatives of the molecule [[beta-Carbolines|''beta''-carboline]]. The structure of ''beta''-carboline is comprised of an indole skeleton fused to a pyridine ring. Harmine, harmaline, and tetrahydroharmine share structural substitutions and they all contain a methoxy group at R<sub>7</sub> and a methyl group at R<sub>1</sub>. They differ in the saturation of their six-member nitrogenous ring. Harmine contains an unsaturated pyridine ring while harmaline contains a dihydrogenated pyridine ring. Tetrahydroharmine is saturated with four additional hydrogen bonds than harmine. | ||
==Pharmacology== | ==Pharmacology== | ||