2C-T-21: Difference between revisions

Line 3:

'''2,5-Dimethoxy-4-ethylfluorothiophenethylamine''' (also known as '''2C-T-21''', or colloquially as '''Aurora''') is a [[psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class that produces [[psychedelic]] effects when [[administered]]. It is a member of the [[2C-x family]] of psychedelic phenethylamines, all of which were derived from the systematic modification of the [[mescaline]] molecule.

2C-T-21 was first synthesized by [[Alexander Shulgin]] and documented in his book [[PiHKAL]] ("Phenethylamines I Have Known and Loved"). The dosage range is listed as 8–12 mg. It is described in various reports as being generally relaxed and clear-headed with mild visual effects.<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal049.shtml|chapter=#49. 2C-T-21}}</ref> In h''Thanatos To Eros, 35 Years of Psychedelic Exploration'', Myron Stolaroff describes it as "not psychedelic, but a wonderful energizer", along with displaying a notable lack of [[appetite suppression]] typically observed with members of its class. However he also mentions concerns regarding toxicity.<ref name=":0">{{cite web|url=http://www.maps.org/index.php?option=com_content&view=article&id=5406|title=Thanatos To Eros, 35 Years of Psychedelic Exploration|author=Myron J. Stolaroff|year=1994|publisher=Multidisciplinary Association for Psychedelic Studies (MAPS)}}</ref>

2C-T-21 was first synthesized by [[Alexander Shulgin]] and documented in his book [[PiHKAL]] ("Phenethylamines I Have Known and Loved"). The dosage range is listed as 8–12 mg. It is described in various reports as being generally relaxed and clear-headed with mild visual effects.<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal049.shtml|chapter=#49. 2C-T-21}}</ref> In ''Thanatos To Eros, 35 Years of Psychedelic Exploration'', Myron Stolaroff describes it as "not psychedelic, but a wonderful energizer", along with displaying a notable lack of [[appetite suppression]] typically observed with members of its class. However he also mentions concerns regarding toxicity.<ref name=":0">{{cite web|url=http://www.maps.org/index.php?option=com_content&view=article&id=5406|title=Thanatos To Eros, 35 Years of Psychedelic Exploration|author=Myron J. Stolaroff|year=1994|publisher=Multidisciplinary Association for Psychedelic Studies (MAPS)}}</ref>

In March 2004, a 22-year-old American male died after ingesting an unknown amount of 2C-T-21. This death became part of a two-year DEA investigation called "Operation Web Tryp" which ended with the arrests of 10 persons involved in the online distribution of [[research chemicals]].<ref name="DEAnews">{{cite web|url=https://www.dea.gov/pubs/pressrel/pr072204.html|archive-url=https://web.archive.org/web/20171022211020/https://www.dea.gov/pubs/pressrel/pr072204.html|archive-date=October 22, 2017|title=DEA Announces Arrests Of Website: Operators Selling Illegal Designer Drugs|date=July 22, 2004|publisher=Drug Enforcement Administration (DEA)}}</ref> 2C-T-21 remains unscheduled in the United States.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-21, although a paper by Daniel Trachsel hypothesizes that one of its metabolites is the poison [https://en.wikipedia.org/wiki/Fluoroacetate fluoroacetate].<ref name=":1">Trachsel, Daniel. (2012) [https://pubmed.ncbi.nlm.nih.gov/22374819 Fluorine in psychedelic phenethylamines], ''Drug Testing and Analysis'', Vol. 4, Issue 7-8 (Special Issue: Psychedelic Substances), July-August 2012, pp. 577-590. [https://doi.org/10.1002/dta.413 DOI:10.1002/dta.413]</ref> It has little history of human usage. Today it is occasionally used for the purposes of [[recreational drug use|recreation]]. It has no history of being sold on the streets and is very sporadically sold online as a grey area research chemical. It is strongly advised to use [[harm reduction practices]] if using this substance.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-21, although a paper by Daniel Trachsel hypothesizes that one of its metabolites is the poison [https://en.wikipedia.org/wiki/Fluoroacetate fluoroacetate].<ref name=":1">Trachsel, Daniel. (2012) [https://pubmed.ncbi.nlm.nih.gov/22374819 Fluorine in psychedelic phenethylamines], ''Drug Testing and Analysis'', Vol. 4, Issue 7-8 (Special Issue: Psychedelic Substances), July-August 2012, pp. 577-590. [https://doi.org/10.1002/dta.413 DOI:10.1002/dta.413]</ref> It has little history of human usage. It is strongly advised to use [[harm reduction practices]] if using this substance.

==Chemistry==

@@ Line 3: / Line 3: @@
 '''2,5-Dimethoxy-4-ethylfluorothiophenethylamine''' (also known as '''2C-T-21''', or colloquially as '''Aurora''') is a [[psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] chemical class that produces [[psychedelic]] effects when [[administered]]. It is a member of the [[2C-x family]] of psychedelic phenethylamines, all of which were derived from the systematic modification of the [[mescaline]] molecule.
-C-T-21 was first synthesized by [[Alexander Shulgin]] and documented in his book [[PiHKAL]] ("Phenethylamines I Have Known and Loved"). The dosage range is listed as 8–12 mg. It is described in various reports as being generally relaxed and clear-headed with mild visual effects.<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal049.shtml|chapter=#49. 2C-T-21}}</ref> In h''Thanatos To Eros, 35 Years of Psychedelic Exploration'', Myron Stolaroff describes it as "not psychedelic, but a wonderful energizer", along with displaying a notable lack of [[appetite suppression]] typically observed with members of its class. However he also mentions concerns regarding toxicity.<ref name=":0">{{cite web|url=http://www.maps.org/index.php?option=com_content&view=article&id=5406|title=Thanatos To Eros, 35 Years of Psychedelic Exploration|author=Myron J. Stolaroff|year=1994|publisher=Multidisciplinary Association for Psychedelic Studies (MAPS)}}</ref>
+C-T-21 was first synthesized by [[Alexander Shulgin]] and documented in his book [[PiHKAL]] ("Phenethylamines I Have Known and Loved"). The dosage range is listed as 8–12 mg. It is described in various reports as being generally relaxed and clear-headed with mild visual effects.<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal049.shtml|chapter=#49. 2C-T-21}}</ref> In ''Thanatos To Eros, 35 Years of Psychedelic Exploration'', Myron Stolaroff describes it as "not psychedelic, but a wonderful energizer", along with displaying a notable lack of [[appetite suppression]] typically observed with members of its class. However he also mentions concerns regarding toxicity.<ref name=":0">{{cite web|url=http://www.maps.org/index.php?option=com_content&view=article&id=5406|title=Thanatos To Eros, 35 Years of Psychedelic Exploration|author=Myron J. Stolaroff|year=1994|publisher=Multidisciplinary Association for Psychedelic Studies (MAPS)}}</ref>
 In March 2004, a 22-year-old American male died after ingesting an unknown amount of 2C-T-21. This death became part of a two-year DEA investigation called "Operation Web Tryp" which ended with the arrests of 10 persons involved in the online distribution of [[research chemicals]].<ref name="DEAnews">{{cite web|url=https://www.dea.gov/pubs/pressrel/pr072204.html|archive-url=https://web.archive.org/web/20171022211020/https://www.dea.gov/pubs/pressrel/pr072204.html|archive-date=October 22, 2017|title=DEA Announces Arrests Of Website: Operators Selling Illegal Designer Drugs|date=July 22, 2004|publisher=Drug Enforcement Administration (DEA)}}</ref> 2C-T-21 remains unscheduled in the United States.
-Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-21, although a paper by Daniel Trachsel hypothesizes that one of its metabolites is the poison [https://en.wikipedia.org/wiki/Fluoroacetate fluoroacetate].<ref name=":1">Trachsel, Daniel. (2012) [https://pubmed.ncbi.nlm.nih.gov/22374819 Fluorine in psychedelic phenethylamines], ''Drug Testing and Analysis'', Vol. 4, Issue 7-8 (Special Issue: Psychedelic Substances), July-August 2012, pp. 577-590. [https://doi.org/10.1002/dta.413 DOI:10.1002/dta.413]</ref> It has little history of human usage. Today it is occasionally used for the purposes of [[recreational drug use|recreation]]. It has no history of being sold on the streets and is very sporadically sold online as a grey area research chemical. It is strongly advised to use [[harm reduction practices]] if using this substance.
+Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-21, although a paper by Daniel Trachsel hypothesizes that one of its metabolites is the poison [https://en.wikipedia.org/wiki/Fluoroacetate fluoroacetate].<ref name=":1">Trachsel, Daniel. (2012) [https://pubmed.ncbi.nlm.nih.gov/22374819 Fluorine in psychedelic phenethylamines], ''Drug Testing and Analysis'', Vol. 4, Issue 7-8 (Special Issue: Psychedelic Substances), July-August 2012, pp. 577-590. [https://doi.org/10.1002/dta.413 DOI:10.1002/dta.413]</ref> It has little history of human usage. It is strongly advised to use [[harm reduction practices]] if using this substance.
 ==Chemistry==