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NEP: Difference between revisions
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'''N-Ethyl-nor-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a lesser-known novel [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] class that produces [[stimulating]], [[euphoric]], and mildly [[entactogenic]] effects when [[Routes of administration|administered]]. | '''N-Ethyl-nor-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a lesser-known novel [[psychoactive class::stimulant]] substance of the [[chemical class::cathinone]] class that produces [[stimulating]], [[euphoric]], and mildly [[entactogenic]] effects when [[Routes of administration|administered]]. | ||
The stimulating effects of NEP are believed to mainly be caused by its activity as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI). The reported entactogenic effects it displays may also be due to its activity as a [[serotonin]] [[reuptake inhibitor]] or [[releasing agent]] in moderate to high doses, although | The stimulating effects of NEP are believed to mainly be caused by its activity as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI). The reported entactogenic effects it displays may also be due to its activity as a [[serotonin]] [[reuptake inhibitor]] or [[releasing agent]] in moderate to high doses, although a recent study has shown very low serotonin reuptake inhibition. <ref name=":0">L. Duart-Castells, N. Nadal-Gratacós, M. Muralter, B. Puster, X. Berzosa, R. Estrada-Tejedor, M. Niello, S. Bhat, D. Pubill, J. Camarasa, H.H. Sitte, E. Escubedo, R. López-Arnau, | ||
Role of amino terminal substitutions in the pharmacological, rewarding and psychostimulant profiles of novel synthetic cathinones, | |||
Neuropharmacology, | |||
Volume 186, | |||
2021, | |||
108475, | |||
ISSN 0028-3908, | |||
<nowiki>https://doi.org/10.1016/j.neuropharm.2021.108475</nowiki>. | |||
(<nowiki>https://www.sciencedirect.com/science/article/pii/S0028390821000290</nowiki>)</ref> | |||
NEP shares a close structural relationship to its parent compound [[pentedrone]], differing by an addition ethyl group on the terminal nitrogen on the carbon chain. This addition reportedly makes it about three times as potent as pentedrone.{{citation needed}} NEP is also closely related to [[N-Ethylhexedrone]] (commonly known as ''Hexen''), and has been reported as producing largely-similar effects. | NEP shares a close structural relationship to its parent compound [[pentedrone]], differing by an addition ethyl group on the terminal nitrogen on the carbon chain. This addition reportedly makes it about three times as potent as pentedrone.{{citation needed}} NEP is also closely related to [[N-Ethylhexedrone]] (commonly known as ''Hexen''), and has been reported as producing largely-similar effects. | ||
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==Pharmacology== | ==Pharmacology== | ||
Due to the lack of research regarding the substance, | Due to the lack of research regarding the substance, a lot of the discussion regarding the pharmacology of it is purely based upon its structure and subjective effect similarities to other [[Substituted cathinone|cathinone]]s such as [[mephedrone]] and others. A recent study has shown that NEP acts as a potent [[Reuptake inhibitor|norepinephrine-dopamine reuptake inhibitor]] (NDRI) with very poor affinity for [[Serotonin|SERT]].<ref name=":0" /> This allows dopamine and norepinephrine to accumulate within the brain, resulting in [[stimulation|stimulating]] and [[physical euphoria|euphoric]] effects. That being said, an interaction with other receptor sites cannot be fully ruled out. | ||
==Subjective effects== | ==Subjective effects== | ||
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===Experience reports=== | ===Experience reports=== | ||
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here: | There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here: | ||
* [https://www.erowid.org/experiences/subs/exp_NEthylpentedrone.shtml Erowid Experience Vaults: N-Ethylpentedrone] | |||
*[https://www.erowid.org/experiences/subs/exp_NEthylpentedrone.shtml Erowid Experience Vaults: N-Ethylpentedrone] | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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===Dangerous interactions=== | ===Dangerous interactions=== | ||
{{DangerousInteractions/Intro}} | {{DangerousInteractions/Intro}} | ||
*'''[[Stimulants]]''' - NEP can be potentially dangerous in combination with other [[stimulants]] as it can [[increased heart rate|increase one's heart rate]] and [[increased blood pressure|blood pressure]] to dangerous levels. | *'''[[Stimulants]]''' - NEP can be potentially dangerous in combination with other [[stimulants]] as it can [[increased heart rate|increase one's heart rate]] and [[increased blood pressure|blood pressure]] to dangerous levels. | ||
{{DangerousInteractions/Stimulants}} | {{DangerousInteractions/Stimulants}} | ||
*'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with [[amphetamine]] and other stimulants. | *'''[[MDMA]]''' - The neurotoxic effects of MDMA may be increased when combined with [[amphetamine]] and other stimulants. | ||
{{DangerousInteractions/MAOI|nt=dopamine}} | {{DangerousInteractions/MAOI|nt=dopamine}} | ||
*'''[[Cocaine]]''' - This combination may increase strain on the heart to dangerous, potentially fatal levels. | *'''[[Cocaine]]''' - This combination may increase strain on the heart to dangerous, potentially fatal levels. | ||
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==Legal status== | ==Legal status== | ||
*'''Brazil''': On September 7, 2018, all cathinone analogues are controlled substances considered illegal to possess, use and distribute. This was made possible due to a blanket ban law appended to Portaria SVS/MS nº 344.<ref>New blanket ban on synthetic illegal drugs is approved (Portuguese) | http://portal.anvisa.gov.br/noticias/-/asset_publisher/FXrpx9qY7FbU/content/combate-a-drogas-ilicitas-sinteticas-fica-mais-facil</ref> | *'''Brazil''': On September 7, 2018, all cathinone analogues are controlled substances considered illegal to possess, use and distribute. This was made possible due to a blanket ban law appended to Portaria SVS/MS nº 344.<ref>New blanket ban on synthetic illegal drugs is approved (Portuguese) | http://portal.anvisa.gov.br/noticias/-/asset_publisher/FXrpx9qY7FbU/content/combate-a-drogas-ilicitas-sinteticas-fica-mais-facil</ref> | ||
*'''China''': NEP is a controlled substance.{{citation needed}} | *'''China''': NEP is a controlled substance.{{citation needed}} | ||
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==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Designer drug]] | *[[Designer drug]] | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/N-Ethylpentedrone N-Ethylpentedrone (Wikipedia)] | *[https://en.wikipedia.org/wiki/N-Ethylpentedrone N-Ethylpentedrone (Wikipedia)] | ||
*[https://isomerdesign.com/PiHKAL/explore.php?id=638 NEP (Isomer Design)] | *[https://isomerdesign.com/PiHKAL/explore.php?id=638 NEP (Isomer Design)] | ||