Ayahuasca: Difference between revisions

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==Subjective effects==

{{effects/base

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*'''[[Effect::Physical autonomy]]'''

*'''[[Effect::Motor control loss]]'''

*'''[[Effect::Sudden loss of consciousness when walking]]'''

*'''[[Effect::Muscle contractions]]'''

*'''[[Effect::Muscle spasms]]'''

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==Preparation==

Traditional ayahuasca is made by brewing the MAOI-containing ''Banisteriopsis caapi'' vine with a DMT-containing plant, such as ''Psychotria viridis''~~. However, an appropriate MAOI and DMT can also be measured into capsules and ingested in succession to similar effect~~. Pharmahuasca refers to a combination that uses a pharmaceutical MAOI instead of a plant. ~~It is important to note there~~ are two types of MAOIs, reversible and irreversible: irreversible MAOIs ~~are much more dangerous as they~~ remain active for ~~at least~~ two weeks rather than a matter of hours. This is particularly noteworthy because in addition to drug interactions, there is co-interaction with tyramine-rich foods and potential to cause a hypertensive crisis. For this reason, it is strongly advised to use a reversible inhibitor of monoamine oxidase A, or [[RIMA]], rather than an irreversible [[MAOI]]. ~~Reversible~~ MAOIs are pharmacologically closer to the [[Harmala alkaloid]] used in traditional ayahuasca.

Traditional ayahuasca is made by brewing the MAOI-containing ''Banisteriopsis caapi'' vine with a DMT-containing plant, such as ''Psychotria viridis''. Pharmahuasca refers to a similar combination that uses a pharmaceutical MAOI instead of a plant. There are two types of MAOIs, reversible and irreversible. It is important to note that irreversible MAOIs remain active for two weeks rather than a matter of hours. This is particularly noteworthy because in addition to drug interactions, there is co-interaction with tyramine-rich foods and potential to cause a hypertensive crisis. For this reason, it is strongly advised to use a reversible inhibitor of monoamine oxidase A, or [[RIMA]], rather than an irreversible [[MAOI]]. In addition, reversible MAOIs are pharmacologically closer to the [[Harmala alkaloid]] used in traditional ayahuasca.

===Changa===

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Changa (pronounced /tʃɑːngɑː/) is a DMT-infused smoking blend. Typically, extracts from DMT-containing plants are combined with a blend of different herbs and ayahuasca vine and/or leaf to create a mix that is 20–50% DMT, akin to a smokeable ayahuasca.

~~<br />~~

~~===Ayahuasca capsules===~~

For ayahuasca capsules, 50mg N,N-DMT and 100mg harmaline is usually the recommended dosage per person. However, combinations of 50 mg harmaline, 50 mg harmine, and 50 mg, N,N-DMT have been tested with success. As a rule, the fewer the β-carbolines, the less nausea there is; the more DMT, the more spectacular the visions. The constituents are put into separate gelatin capsules. The capsules with harmaline/harmine are swallowed first and then the capsule containing the DMT is taken 15 to 20 minutes later.

~~<br />~~

===Pharmahuasca===

~~There~~ are ~~purely synthetic MAO inhibitors which can be used in place of~~ harmaline/harmine. ~~In this case a reversible~~ inhibitor ~~of monamine oxidase A (~~[[~~RIMA~~]]) should be ~~chosen, the ideal choice being [[moclobemide]]. It~~ is ~~strongly advised not to use~~ irreversible [[MAOI]]~~<nowiki/>s such as [[isocarboxazid]] (Marplan) due to~~ several drug-drug and drug-food interactions ~~as well as its extremely lengthly duration of action~~.<ref>{{cite book | vauthors=((Ott, J.)) | date= 1994 | title=Ayahuasca analogues: Pangæan entheogens | publisher=Natural Products Co | edition=1st ed. | isbn=9780961423445}}~~</ref> While RIMAs are safer than irreversible MAOIs, there are still a number of dangerous interactions so care must be taken.~~

For pharmahuasca, 50 mg N,N-DMT and 100 mg harmaline is usually the recommended dosage per person. However, combinations of 50 mg harmaline, 50 mg harmine, and 50 mg, N,N-DMT have been tested with success. As a rule, the fewer the β-carbolines, the less nausea there is; the more DMT, the more spectacular the visions. The constituents are put into separate gelatin capsules. The capsules with harmaline/harmine are swallowed first and then the capsule containing the DMT is taken 15 to 20 minutes later. The purely synthetic MAO inhibitor [[isocarboxazid]] (Marplan) is suitable in place of harmaline and harmine, although caution should be taken as this is an irreversible [[MAOI]], marking several drug-drug and drug-food interactions.<ref>{{cite book | vauthors=((Ott, J.)) | date= 1994 | title=Ayahuasca analogues: Pangæan entheogens | publisher=Natural Products Co | edition=1st ed. | isbn=9780961423445}}</ref>

For pharmahoasa an initial dose of 75mg moclobemide and 50mg of N,N-DMT is suggested. For a stronger experience, 150mg moclobemide can be taken. It is noted that moclobemide can facilitate a less nauseating and sedating experience than haraline/harmine.<ref>Morris, Hamilton. 2022. "Hamilton Morris Interviews Dr. Denis McKenna - New Natural Psychedelics", 48:32, ''YouTube''. https://youtu.be/MWxH6hhpISA?t=2431</ref>

===Recipes and preparation methods===

@@ Line 27: / Line 27: @@
 ==Subjective effects==
 {{Preamble/SubjectiveEffects}}
 {{effects/base
@@ Line 40: / Line 41: @@
 *'''[[Effect::Physical autonomy]]'''
 *'''[[Effect::Motor control loss]]'''
+*'''[[Effect::Sudden loss of consciousness when walking]]'''
 *'''[[Effect::Muscle contractions]]'''
 *'''[[Effect::Muscle spasms]]'''
@@ Line 163: / Line 165: @@
 ==Preparation==
-Traditional ayahuasca is made by brewing the MAOI-containing ''Banisteriopsis caapi'' vine with a DMT-containing plant, such as ''Psychotria viridis''. However, an appropriate MAOI and DMT can also be measured into capsules and ingested in succession to similar effect. Pharmahuasca refers to a combination that uses a pharmaceutical MAOI instead of a plant. It is important to note there are two types of MAOIs, reversible and irreversible: irreversible MAOIs are much more dangerous as they remain active for at least two weeks rather than a matter of hours. This is particularly noteworthy because in addition to drug interactions, there is co-interaction with tyramine-rich foods and potential to cause a hypertensive crisis. For this reason, it is strongly advised to use a reversible inhibitor of monoamine oxidase A, or [[RIMA]], rather than an irreversible [[MAOI]]. Reversible MAOIs are pharmacologically closer to the [[Harmala alkaloid]] used in traditional ayahuasca.
+Traditional ayahuasca is made by brewing the MAOI-containing ''Banisteriopsis caapi'' vine with a DMT-containing plant, such as ''Psychotria viridis''. Pharmahuasca refers to a similar combination that uses a pharmaceutical MAOI instead of a plant. There are two types of MAOIs, reversible and irreversible. It is important to note that irreversible MAOIs remain active for two weeks rather than a matter of hours. This is particularly noteworthy because in addition to drug interactions, there is co-interaction with tyramine-rich foods and potential to cause a hypertensive crisis. For this reason, it is strongly advised to use a reversible inhibitor of monoamine oxidase A, or [[RIMA]], rather than an irreversible [[MAOI]]. In addition, reversible MAOIs are pharmacologically closer to the [[Harmala alkaloid]] used in traditional ayahuasca.
 ===Changa===
@@ Line 169: / Line 171: @@
 Changa (pronounced /tʃɑːngɑː/) is a DMT-infused smoking blend. Typically, extracts from DMT-containing plants are combined with a blend of different herbs and ayahuasca vine and/or leaf to create a mix that is 20–50% DMT, akin to a smokeable ayahuasca.
-<br />
-===Ayahuasca capsules===
-For ayahuasca capsules, 50mg N,N-DMT and 100mg harmaline is usually the recommended dosage per person. However, combinations of 50&nbsp;mg harmaline, 50&nbsp;mg harmine, and 50&nbsp;mg, N,N-DMT have been tested with success. As a rule, the fewer the β-carbolines, the less nausea there is; the more DMT, the more spectacular the visions. The constituents are put into separate gelatin capsules. The capsules with harmaline/harmine are swallowed first and then the capsule containing the DMT is taken 15 to 20 minutes later.
-<br />
 ===Pharmahuasca===
-There are purely synthetic MAO inhibitors which can be used in place of harmaline/harmine. In this case a reversible inhibitor of monamine oxidase A ([[RIMA]]) should be chosen, the ideal choice being [[moclobemide]]. It is strongly advised not to use irreversible [[MAOI]]<nowiki/>s such as [[isocarboxazid]] (Marplan) due to several drug-drug and drug-food interactions as well as its extremely lengthly duration of action.<ref>{{cite book | vauthors=((Ott, J.)) | date= 1994 | title=Ayahuasca analogues: Pangæan entheogens | publisher=Natural Products Co | edition=1st ed. | isbn=9780961423445}}</ref> While RIMAs are safer than irreversible MAOIs, there are still a number of dangerous interactions so care must be taken.
+For pharmahuasca, 50&nbsp;mg N,N-DMT and 100&nbsp;mg harmaline is usually the recommended dosage per person. However, combinations of 50&nbsp;mg harmaline, 50&nbsp;mg harmine, and 50&nbsp;mg, N,N-DMT have been tested with success. As a rule, the fewer the β-carbolines, the less nausea there is; the more DMT, the more spectacular the visions. The constituents are put into separate gelatin capsules. The capsules with harmaline/harmine are swallowed first and then the capsule containing the DMT is taken 15 to 20 minutes later. The purely synthetic MAO inhibitor [[isocarboxazid]] (Marplan) is suitable in place of harmaline and harmine, although caution should be taken as this is an irreversible [[MAOI]], marking several drug-drug and drug-food interactions.<ref>{{cite book | vauthors=((Ott, J.)) | date= 1994 | title=Ayahuasca analogues: Pangæan entheogens | publisher=Natural Products Co | edition=1st ed. | isbn=9780961423445}}</ref>
-For pharmahoasa an initial dose of 75mg moclobemide and 50mg of N,N-DMT is suggested. For a stronger experience, 150mg moclobemide can be taken. It is noted that moclobemide can facilitate a less nauseating and sedating experience than haraline/harmine.<ref>Morris, Hamilton. 2022. "Hamilton Morris Interviews Dr. Denis McKenna - New Natural Psychedelics", 48:32, ''YouTube''. https://youtu.be/MWxH6hhpISA?t=2431</ref>
 ===Recipes and preparation methods===