Ayahuasca: Difference between revisions

* [https://www.erowid.org/experiences/subs/exp_Ayahuasca.shtml Erowid Experience Vaults: Ayahuasca]

Traditional ayahuasca is made by brewing the MAOI-containing ''Banisteriopsis caapi'' vine with a DMT-containing plant, such as ''Psychotria viridis''. Pharmahuasca refers to a similar combination that uses a pharmaceutical MAOI instead of a plant. There are two types of MAOIs, reversible and irreversible. It is important to note that irreversible MAOIs remain active for two weeks rather than a matter of hours. This is particularly noteworthy because in addition to drug interactions, there is co-interaction with tyramine-rich foods and potential to cause a hypertensive crisis. For this reason, it is strongly advised to use a reversible inhibitor of monoamine oxidase A, or [[RIMA]], rather than an irreversible [[MAOI]]. In addition, reversible MAOIs are pharmacologically closer to the [[Harmala alkaloid]] used in traditional ayahuasca.

For pharmahuasca, 50&nbsp;mg N,N-DMT and 100&nbsp;mg harmaline is usually the recommended dosage per person. However, combinations of 50&nbsp;mg harmaline, 50&nbsp;mg harmine, and 50&nbsp;mg, N,N-DMT have been tested with success. As a rule, the fewer the β-carbolines, the less nausea there is; the more DMT, the more spectacular the visions. The constituents are put into separate gelatin capsules. The capsules with harmaline/harmine are swallowed first and then the capsule containing the DMT is taken 15 to 20 minutes later. The purely synthetic MAO inhibitor [[isocarboxazid]] (Marplan) is suitable in place of harmaline and harmine, although caution should be taken as this is an irreversible [[MAOI]], marking several drug-drug and drug-food interactions.<ref>{{cite book | vauthors=((Ott, J.)) | date= 1994 | title=Ayahuasca analogues: Pangæan entheogens | publisher=Natural Products Co | edition=1st ed. | isbn=9780961423445}}</ref>

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** Louisiana: Except for ornamental purposes, growing, selling or possessing of these ayahuasca plants are prohibited by Louisiana State Act 159:<ref>{{Citation | title=Louisiana Laws - Louisiana State Legislature | url=http://legis.la.gov/Legis/Law.aspx?d=321523}}</ref>

*** ''Anadenanthera colubrina''

*** ''Banisteriopsis spp.''

*** ''[[Mimosa hostilis]]''

*** ''[[Peganum harmala]]''

*** ''Tetrapteris methystica''

*[[Harmala alkaloids]]