DPT: Difference between revisions

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Studies on rodents have found that the effectiveness with which a selective 5-HT2A receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor antagonist also imply a 5-HT1A-mediated component to the actions of DPT.<ref>~~antegrossi WE~~, Reissig CJ, Katz EB, Yarosh HL, Rice KC, Winter ~~JC (January 2008~~)~~. "~~Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): ~~possible~~ mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents~~". ''Pharmacology, Biochemistry, and Behavior''. '''~~88~~''' (~~3): ~~358–65~~. doi:10.1016/j.pbb.2007.09.007~~. PMC 2322878. <nowiki>PMID 17905422</nowiki>.~~</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.

Studies on rodents have found that the effectiveness with which a selective 5-HT2A receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT2A receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor antagonist also imply a 5-HT1A-mediated component to the actions of DPT.<ref>{{cite journal | vauthors=((Fantegrossi, W.)), ((Reissig, C.)), ((Katz, E.)), ((Yarosh, H.)), ((Rice, K.)), ((Winter, J.)) | journal=Pharmacology Biochemistry and Behavior | title=Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents | volume=88 | issue=3 | pages=358–365 | date= January 2008 | url=https://linkinghub.elsevier.com/retrieve/pii/S0091305707002894 | issn=00913057 | doi=10.1016/j.pbb.2007.09.007}}</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.

==Subjective effects==

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{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage. There has been one death associated with the use DPT and seizures, but the dose is unknown.<ref>https://www.startribune.com/carver-county-teen-s-death-puts-spotlight-on-ease-of-purchasing-synthetic-drugs-online/330344661/</ref>

The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage. There has been one death associated with the use DPT and seizures, but the dose is unknown.<ref>{{Citation | vauthors=((Tribune, B. D. S.)) | title=Carver County teen’s death puts spotlight on ease of purchasing synthetic drugs online | url=https://www.startribune.com/carver-county-teen-s-death-puts-spotlight-on-ease-of-purchasing-synthetic-drugs-online/330344661/}}</ref>

Anecdotal reports from those who have taken DPT suggests that negative health effects are not likely to occur from simply trying it by itself at low to moderate doses and using it very sparingly (although nothing can be guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

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 {{pharmacology}}
 {{Further|Serotonergic psychedelic}}
-Studies on rodents have found that the effectiveness with which a selective 5-HT<sub>2A</sub> receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT<sub>2A</sub> receptor is an important site of action for DPT, but the modulatory actions of a 5-HT<sub>1A</sub> receptor antagonist also imply a 5-HT<sub>1A</sub>-mediated component to the actions of DPT.<ref>antegrossi WE, Reissig CJ, Katz EB, Yarosh HL, Rice KC, Winter JC (January 2008). "Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents". ''Pharmacology, Biochemistry, and Behavior''. '''88''' (3): 358–65. doi:10.1016/j.pbb.2007.09.007. PMC 2322878. <nowiki>PMID 17905422</nowiki>.</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
+Studies on rodents have found that the effectiveness with which a selective 5-HT<sub>2A</sub> receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT<sub>2A</sub> receptor is an important site of action for DPT, but the modulatory actions of a 5-HT<sub>1A</sub> receptor antagonist also imply a 5-HT<sub>1A</sub>-mediated component to the actions of DPT.<ref>{{cite journal | vauthors=((Fantegrossi, W.)), ((Reissig, C.)), ((Katz, E.)), ((Yarosh, H.)), ((Rice, K.)), ((Winter, J.)) | journal=Pharmacology Biochemistry and Behavior | title=Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents | volume=88 | issue=3 | pages=358–365 | date= January 2008 | url=https://linkinghub.elsevier.com/retrieve/pii/S0091305707002894 | issn=00913057 | doi=10.1016/j.pbb.2007.09.007}}</ref> The role of these interactions and how they result in the [[psychedelic]] experience remains the subject of ongoing scientific investigation.
 ==Subjective effects==
@@ Line 133: / Line 133: @@
 {{toxicity}}
 {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
-The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage. There has been one death associated with the use DPT and seizures, but the dose is unknown.<ref>https://www.startribune.com/carver-county-teen-s-death-puts-spotlight-on-ease-of-purchasing-synthetic-drugs-online/330344661/</ref>
+The toxicity and long-term health effects of recreational DPT do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because DPT is a [[research chemical]] with very little history of human usage. There has been one death associated with the use DPT and seizures, but the dose is unknown.<ref>{{Citation | vauthors=((Tribune, B. D. S.)) | title=Carver County teen’s death puts spotlight on ease of purchasing synthetic drugs online | url=https://www.startribune.com/carver-county-teen-s-death-puts-spotlight-on-ease-of-purchasing-synthetic-drugs-online/330344661/}}</ref>
 Anecdotal reports from those who have taken DPT suggests that negative health effects are not likely to occur from simply trying it by itself at low to moderate doses and using it very sparingly (although nothing can be guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.