Pregabalin: Difference between revisions

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|{{effects/physical|

*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' - Pregabalin produces mild sedation and improves sleep onset latency modestly. Several studies have shown pregabalin improves sleep quality of those who take it for various indications. It is unknown if this effect is carried over to those who take it recreationally.<ref> Time to improvement of pain and sleep quality in clinical trials of pregabalin for the treatment of fibromyalgia. | https://www.ncbi.nlm.nih.gov/pubmed/25529830</ref><ref> Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an 8-week treatment course. | https://www.ncbi.nlm.nih.gov/pubmed/22156921</ref> However, it is not an overly sedating substance when taken in the daytime.

*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' - Pregabalin is known to be physically stimulating on the come up, encouraging movement in a unique fashion similar to [GHB]]. On the come down, Pregabalin produces mild sedation and improves sleep onset latency modestly. Several studies have shown pregabalin improves sleep quality of those who take it for various indications. It is unknown if this effect is carried over to those who take it recreationally.<ref> Time to improvement of pain and sleep quality in clinical trials of pregabalin for the treatment of fibromyalgia. | https://www.ncbi.nlm.nih.gov/pubmed/25529830</ref><ref> Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an 8-week treatment course. | https://www.ncbi.nlm.nih.gov/pubmed/22156921</ref> However, it is not an overly sedating substance when taken in the daytime.

*'''[[Effect::Appetite enhancement]]''' - This effect is not particularly prominent, but is reported to occur in some people. It can have a synergistic effect when combined with [[cannabis]].

*'''[[Effect::Pain relief]]''' - Pregabalin is effective against certain types of chronic pain, particularly neuropathic pain, but not against acute pain.<ref> Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915349/</ref>

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*'''[[Effect::Increased libido]]''' ''or'' '''[[Effect::Decreased libido]]'''

*'''[[Effect::Frequent urination]]'''

*'''[[Effect::Difficulty urinating]]'''

*'''[[Effect::Motor control loss]]'''

*'''[[Effect::Seizure suppression]]'''<ref> Pregabalin | http://www.epilepsy.com/medications/pregabalin </ref><ref> Pregabalin for the management of partial epilepsy | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646650/</ref>

@@ Line 41: / Line 41: @@
 |{{effects/physical|
-*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' -  Pregabalin produces mild sedation and improves sleep onset latency modestly. Several studies have shown pregabalin improves sleep quality of those who take it for various indications. It is unknown if this effect is carried over to those who take it recreationally.<ref> Time to improvement of pain and sleep quality in clinical trials of pregabalin for the treatment of fibromyalgia. | https://www.ncbi.nlm.nih.gov/pubmed/25529830</ref><ref> Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an 8-week treatment course. | https://www.ncbi.nlm.nih.gov/pubmed/22156921</ref> However, it is not an overly sedating substance when taken in the daytime.
+*'''[[Effect::Stimulation]]''' & '''[[Effect::Sedation]]''' - Pregabalin is known to be physically stimulating on the come up, encouraging movement in a unique fashion similar to [GHB]]. On the come down, Pregabalin produces mild sedation and improves sleep onset latency modestly. Several studies have shown pregabalin improves sleep quality of those who take it for various indications. It is unknown if this effect is carried over to those who take it recreationally.<ref> Time to improvement of pain and sleep quality in clinical trials of pregabalin for the treatment of fibromyalgia. | https://www.ncbi.nlm.nih.gov/pubmed/25529830</ref><ref> Pregabalin beneficial effects on sleep quality or health-related quality of life are poorly correlated with reduction on pain intensity after an 8-week treatment course. | https://www.ncbi.nlm.nih.gov/pubmed/22156921</ref> However, it is not an overly sedating substance when taken in the daytime.
 *'''[[Effect::Appetite enhancement]]''' - This effect is not particularly prominent, but is reported to occur in some people. It can have a synergistic effect when combined with [[cannabis]].
 *'''[[Effect::Pain relief]]''' - Pregabalin is effective against certain types of chronic pain, particularly neuropathic pain, but not against acute pain.<ref> Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915349/</ref>
@@ Line 54: / Line 54: @@
 *'''[[Effect::Increased libido]]''' ''or'' '''[[Effect::Decreased libido]]'''
 *'''[[Effect::Frequent urination]]'''
+*'''[[Effect::Difficulty urinating]]'''
 *'''[[Effect::Motor control loss]]'''
 *'''[[Effect::Seizure suppression]]'''<ref> Pregabalin | http://www.epilepsy.com/medications/pregabalin </ref><ref> Pregabalin for the management of partial epilepsy | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646650/</ref>