Tizanidine: Difference between revisions

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Tizanidine is a central α2 adrenergic agonist. The relationship between the α2 receptor agonism and the spasmolytic function of tizanidine is not fully understood <ref> Katzung, Bertram G. (30 November 2017). Basic & clinical pharmacology. Katzung, Bertram G. (Fourteenth ed.). New York. p. 487. ISBN 9781259641152. OCLC 1015240036 </ref> .

While recreational use is extremely rare, some users take tizanidine for its standalone sedative effects or to potentiate the effects of [[opiates]]. In higher doses, tizanidine is capable of inducing [[hallucinations]], [[psychosis]], and [[delirium]].

While recreational use is extremely rare, some users take tizanidine for its standalone sedative effects or to potentiate the effects of [[opiates]]. In higher doses, tizanidine is capable of inducing [[hallucinations]], [[psychosis]], and [[delirium]] <ref> pmhdev. [https://web.archive.org/web/20121111213511/http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000106/ Tizanidine]. PubMed Health. Archived from [https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000106/ the original] on 11 November 2012. </ref>.

==Chemistry==

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 Tizanidine is a central α2 adrenergic agonist. The relationship between the α2 receptor agonism and the spasmolytic function of tizanidine is not fully understood <ref> Katzung, Bertram G. (30 November 2017). Basic & clinical pharmacology. Katzung, Bertram G. (Fourteenth ed.). New York. p. 487. ISBN 9781259641152. OCLC 1015240036 </ref> .
-While recreational use is extremely rare, some users take tizanidine for its standalone sedative effects or to potentiate the effects of [[opiates]]. In higher doses, tizanidine is capable of inducing [[hallucinations]], [[psychosis]], and [[delirium]].
+While recreational use is extremely rare, some users take tizanidine for its standalone sedative effects or to potentiate the effects of [[opiates]]. In higher doses, tizanidine is capable of inducing [[hallucinations]], [[psychosis]], and [[delirium]] <ref>  pmhdev. [https://web.archive.org/web/20121111213511/http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000106/ Tizanidine]. PubMed Health. Archived from [https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000106/ the original] on 11 November 2012. </ref>.
 ==Chemistry==