Tizanidine: Difference between revisions

Line 18:

Tizanidine has also been found to have [[anticonvulsant]] effects against strychnine-induced seizures but not against [[GABA]]-induced seizures. The α2 receptor mediated inhibition of inter-neuronal activity appears to be the cause of Tizanidine's anti-convulsant properties.

Tizanidine has an oral bioavailability of 20-34% and an elimination half-life of 2.5 hours. It attains steady-state concentration within 24-48 hours after administration <ref> S~~;, M. I. K. (n.d.)~~. Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors. ~~Japanese journal of pharmacology~~. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1331591/ </ref>.

Tizanidine has an oral bioavailability of 20-34% and an elimination half-life of 2.5 hours. It attains steady-state concentration within 24-48 hours after administration <ref>Muramatsu I, Kigoshi S. Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors. Jpn J Pharmacol. 1992 Aug;59(4):457-9. doi: 10.1254/jjp.59.457. PMID: 1331591.. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1331591/ </ref>.

The table below compares the selectivity of Tizanidine and other drugs to the imidzaoline-receptor and the α2 receptors in rats. Tizanidine has a significantly greater selectivity to the imidazoline receptor than clonidine. The imidazoline receptor selectivity of tizanidine may be responsible for its unique pharmacological profile<ref>S;, M. I. K. (n.d.). Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors. Japanese journal of pharmacology. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1331591/ </ref>.

@@ Line 18: / Line 18: @@
 Tizanidine has also been found to have [[anticonvulsant]] effects against strychnine-induced seizures but not against [[GABA]]-induced seizures. The α2 receptor mediated inhibition of inter-neuronal activity appears to be the cause of Tizanidine's anti-convulsant properties.
-Tizanidine has an oral bioavailability of 20-34% and an elimination half-life of 2.5 hours. It attains steady-state concentration within 24-48 hours after administration <ref> S;, M. I. K. (n.d.). Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors. Japanese journal of pharmacology. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1331591/  </ref>.
+Tizanidine has an oral bioavailability of 20-34% and an elimination half-life of 2.5 hours. It attains steady-state concentration within 24-48 hours after administration <ref>Muramatsu I, Kigoshi S. Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors. Jpn J Pharmacol. 1992 Aug;59(4):457-9. doi: 10.1254/jjp.59.457. PMID: 1331591.. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1331591/  </ref>.
 The table below compares the selectivity of Tizanidine and other drugs to the imidzaoline-receptor and the α2 receptors in rats. Tizanidine has a significantly greater selectivity to the imidazoline receptor than clonidine. The imidazoline receptor selectivity of tizanidine may be responsible for its unique pharmacological profile<ref>S;, M. I. K. (n.d.). Tizanidine may discriminate between imidazoline-receptors and alpha 2-adrenoceptors. Japanese journal of pharmacology. Retrieved from https://pubmed.ncbi.nlm.nih.gov/1331591/ </ref>.