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Tizanidine: Difference between revisions
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{{SubstanceBox/Tizanidine}} | {{SubstanceBox/Tizanidine}} | ||
'''Tizanidine''' (known by the trade names '''Zanaflex''' and '''Trinex''' among others) is a depressant substance of the imidazoline class. Tizanidine is primarily used primarily as an antispasmodic drug. | '''Tizanidine''' (known by the trade names '''Zanaflex''' and '''Trinex''' among others) is a depressant substance of the imidazoline class. Tizanidine is primarily used primarily as an antispasmodic drug. Tizanidine's effectivness is similar to that of baclofen or diazepam <ref> Wagstaff AJ, Bryson HM. Tizanidine. A review of its pharmacology, clinical efficacy and tolerability in the management of spasticity associated with cerebral and spinal disorders. Drugs. 1997 Mar;53(3):435-52. doi: 10.2165/00003495-199753030-00007. PMID: 9074844. </ref>. | ||
Tizanidine is a central α2 receptor agonist. The relationship between the α2 receptor agonism and the spasmolytic function of tizanidine is not fully understood. | Tizanidine is a central α2 receptor agonist. The relationship between the α2 receptor agonism and the spasmolytic function of tizanidine is not fully understood. | ||