Tizanidine: Difference between revisions

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It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance.

While no long term studies of tizanidine use in humans have been done, studies done in animals indicate no signs of long term carcinogenicity. However, tizanidine has been shown to have a developmental effect on young rats<ref> https://www.drugbank.ca/drugs/DB00697 </ref>.

Some long term tizanidine use has been attributed to liver problems and in extreme cases, liver failure and death<ref> Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Tizanidine. [Updated 2017 Jan 30]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548048/ </ref>.

===Lethal dosage===

The LD50 of oral tizanidine in rats was found to be 414mg/kg in rats and 235 mg/kg in mice.

The LD50 of oral tizanidine in rats was found to be 414mg/kg in rats and 235 mg/kg in mice<ref> https://www.drugbank.ca/drugs/DB00697 </ref>.

===Tolerance and addiction potential===

While dependence is rare, use of Tizanidine exceeding 36mg daily over an extended period of time can lead to hypertensive withdrawals. In cases where dependence has been built, a user should taper to avoid a hypertensive crisis.

While dependence is rare, use of Tizanidine exceeding 36mg daily over an extended period of time can lead to hypertensive withdrawals. In cases where dependence has been built, a user should taper to avoid a hypertensive crisis<ref> "Tizanidine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019. </ref>.

===Dangerous interactions===

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 {{toxicity}}
 It is strongly recommended that one use [[responsible use|harm reduction practices]] when using this substance.
+While no long term studies of tizanidine use in humans have been done, studies done in animals indicate no signs of long term carcinogenicity. However, tizanidine has been shown to have a developmental effect on young rats<ref> https://www.drugbank.ca/drugs/DB00697 </ref>.
+Some long term tizanidine use has been attributed to liver problems and in extreme cases, liver failure and death<ref> Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Tizanidine. [Updated 2017 Jan 30]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548048/ </ref>.
 ===Lethal dosage===
-The LD50 of oral tizanidine in rats was found to be 414mg/kg in rats and 235 mg/kg in mice.
+The LD50 of oral tizanidine in rats was found to be 414mg/kg in rats and 235 mg/kg in mice<ref> https://www.drugbank.ca/drugs/DB00697 </ref>.
 ===Tolerance and addiction potential===
-While dependence is rare, use of Tizanidine exceeding 36mg daily over an extended period of time can lead to hypertensive withdrawals. In cases where dependence has been built, a user should taper to avoid a hypertensive crisis.
+While dependence is rare, use of Tizanidine exceeding 36mg daily over an extended period of time can lead to hypertensive withdrawals. In cases where dependence has been built, a user should taper to avoid a hypertensive crisis<ref> "Tizanidine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019. </ref>.
 ===Dangerous interactions===
 {{DangerousInteractions}}