Talk:PPAP: Difference between revisions

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{{headerpanel|{{approval}}}}

{{SubstanceBox/PPAP}}'''(-)-1-Phenyl-2-propylaminopentane''' (also known as '''(-)-PPAP''' and '''N,α-dipropylphenethylamine''') is a [[psychoactive class::stimulant]] of the [[chemical class::substituted phenethylamine]] class and a derivative of [[Selegiline]].<ref>{{cite journal | title=The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant. |vauthors=Knoll J, Knoll B, Török Z, Timár J, Yasar S | journal=Archives internationales de Pharmacodynamie et de Thérapie | date=March–April 1992 | issue=316 | pages=5–29 | pmid=1356324}}</ref> It is mainly considered as a [[nootropic]] and [[research chemical]].

~~{{SummarySheet}}~~

'''(-)-1-Phenyl-2-propylaminopentane''' (also known as '''(-)-PPAP''' and '''N,α-dipropylphenethylamine''') is a [[psychoactive class::stimulant]] of the [[chemical class::substituted phenethylamine]] class and a derivative of [[Selegiline]].<ref>{{cite journal | title=The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant. |vauthors=Knoll J, Knoll B, Török Z, Timár J, Yasar S | journal=Archives internationales de Pharmacodynamie et de Thérapie | date=March–April 1992 | issue=316 | pages=5–29 | pmid=1356324}}</ref> It is mainly considered as a [[nootropic]] and [[research chemical]].

PPAP is classified as a [[Monoamine neurotransmitter|monoaminergic]] activity enhancer that stimulates the impulse propagation mediated transmitter release of the [[neurotransmitter]]s [[dopamine]], [[norepinephrine]] and [[serotonin]] in the brain. Unlike stimulants such as [[amphetamine]], which release a flood of monoamine neurotransmitters in an uncontrolled manner, PPAP instead only increases the amount of neurotransmitters that get released when a [[neuron]] is stimulated by receiving an impulse from a neighbouring neuron. Both amphetamine and (-)-PPAP promote the release of monoamines and deuteramines, however while amphetamine causes neurons to dump neurotransmitter stores into the [[synapse]] regardless of external input, PPAP does not influence the pattern of neurotransmitter release and instead releases a larger amount of neurotransmitters than normal.<ref>{{cite journal | url=http://www.sciencedirect.com/science/article/pii/0024320596000148 | title=(−)Deprenyl and (−)1-phenyl-2-propylaminopentane, [(−) PPAP] act primarily as potent stimulants of action potential — transmitter release coupling in the catecholaminergic neurons |author1=Joseph Knoll |author2=Ildikó Miklya |author3=Berta Knoll |author4=Raissa Markó |author5=Károly Kelemen | journal=Life Sciences | date=February 1996 | volume=58 | issue=10 | pages=817–827 | doi=10.1016/0024-3205(96)00014-8 | pmid=8602114}}</ref>

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*'''[[DangerousInteraction::MDMA]]''' - The neurotoxic effects of [[MDMA]] may be increased when combined with other stimulants.

==Legal status==

*'''United States''': PPAP has no schedule assigned to it in the U.S., making it unregulated and therefore legally available for anyone in the country to buy, possess and use.

*'''United Kingdom:''' It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>

==See also==

*[[Responsible use]]

*[[Nootropics]]

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==External links==

*[https://en.wikipedia.org/wiki/Phenylpropylaminopentane Phenylpropylaminopentane (Wikipedia)]

*[https://isomerdesign.com/PiHKAL/explore.php?id=10771 1-Phenyl-2-propylaminopentane (TiHKAL / Isomer Design)]

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 {{headerpanel|{{approval}}}}
 {{distinguish|(-)-R-PPAP}}
-{{SubstanceBox/PPAP}}
+{{SubstanceBox/PPAP}}'''(-)-1-Phenyl-2-propylaminopentane''' (also known as '''(-)-PPAP''' and '''N,α-dipropylphenethylamine''') is a [[psychoactive class::stimulant]] of the [[chemical class::substituted phenethylamine]] class and a derivative of [[Selegiline]].<ref>{{cite journal | title=The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant. |vauthors=Knoll J, Knoll B, Török Z, Timár J, Yasar S | journal=Archives internationales de Pharmacodynamie et de Thérapie | date=March–April 1992 | issue=316 | pages=5–29 | pmid=1356324}}</ref> It is mainly considered as a [[nootropic]] and [[research chemical]].
-{{SummarySheet}}
-'''(-)-1-Phenyl-2-propylaminopentane''' (also known as '''(-)-PPAP''' and '''N,α-dipropylphenethylamine''') is a [[psychoactive class::stimulant]] of the [[chemical class::substituted phenethylamine]] class and a derivative of [[Selegiline]].<ref>{{cite journal | title=The pharmacology of 1-phenyl-2-propylamino-pentane (PPAP), a deprenyl-derived new spectrum psychostimulant. |vauthors=Knoll J, Knoll B, Török Z, Timár J, Yasar S | journal=Archives internationales de Pharmacodynamie et de Thérapie | date=March–April 1992 | issue=316 | pages=5–29 | pmid=1356324}}</ref> It is mainly considered as a [[nootropic]] and [[research chemical]].
 PPAP is classified as a [[Monoamine neurotransmitter|monoaminergic]] activity enhancer that stimulates the impulse propagation mediated transmitter release of the [[neurotransmitter]]s [[dopamine]], [[norepinephrine]] and [[serotonin]] in the brain. Unlike stimulants such as [[amphetamine]], which release a flood of monoamine neurotransmitters in an uncontrolled manner, PPAP instead only increases the amount of neurotransmitters that get released when a [[neuron]] is stimulated by receiving an impulse from a neighbouring neuron. Both amphetamine and (-)-PPAP promote the release of monoamines and deuteramines, however while amphetamine causes neurons to dump neurotransmitter stores into the [[synapse]] regardless of external input, PPAP does not influence the pattern of neurotransmitter release and instead releases a larger amount of neurotransmitters than normal.<ref>{{cite journal | url=http://www.sciencedirect.com/science/article/pii/0024320596000148 | title=(−)Deprenyl and (−)1-phenyl-2-propylaminopentane, [(−) PPAP] act primarily as potent stimulants of action potential — transmitter release coupling in the catecholaminergic neurons |author1=Joseph Knoll |author2=Ildikó Miklya |author3=Berta Knoll |author4=Raissa Markó |author5=Károly Kelemen | journal=Life Sciences | date=February 1996 | volume=58 | issue=10 | pages=817–827 | doi=10.1016/0024-3205(96)00014-8 | pmid=8602114}}</ref>
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 {{DangerousInteractions/Intro}}
 {{DangerousInteractions/Stimulants|self=PPAP}}
 {{DangerousInteractions/MAOI|nt=dopamine}}
 *'''[[DangerousInteraction::MDMA]]''' - The neurotoxic effects of [[MDMA]] may be increased when combined with other stimulants.
 ==Legal status==
 *'''United States''': PPAP has no schedule assigned to it in the U.S., making it unregulated and therefore legally available for anyone in the country to buy, possess and use.
 *'''United Kingdom:''' It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
 ==See also==
 *[[Responsible use]]
 *[[Nootropics]]
@@ Line 78: / Line 78: @@
 ==External links==
 *[https://en.wikipedia.org/wiki/Phenylpropylaminopentane Phenylpropylaminopentane (Wikipedia)]
 *[https://isomerdesign.com/PiHKAL/explore.php?id=10771 1-Phenyl-2-propylaminopentane (TiHKAL / Isomer Design)]