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PCP: Difference between revisions
>Sospeedyos Added hunger and bowel movement effects |
>Sospeedyos Added effects and pharmacology with citations |
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===Common names=== | ===Common names=== | ||
Common street names for PCP are the peace pill, angel dust, crystal joints, rocket fuel, sawgrass, zoom, the sheets, and elephant tranquilizer.<ref name="Journey" /> | Common street names for PCP are the peace pill, angel dust, sherm sticks, peeps, crystal joints, rocket fuel, sawgrass, zoom, the sheets, and elephant tranquilizer.<ref name="Journey" /> | ||
==Chemistry== | ==Chemistry== | ||
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PCP acts as an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the notorious “[http://en.wikipedia.org/wiki/K-hole k-hole].” | PCP acts as an [[NMDA receptor antagonist]]. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the notorious “[http://en.wikipedia.org/wiki/K-hole k-hole].” | ||
PCP also acts as a | Unlike ketamine, PCP also shows appreciable affinity for antagonizing the PCP2 glutamate receptor.<ref>[https://zenodo.org/record/1258623 Rothman RB (1994). "PCP site 2: a high affinity MK-801-insensitive phencyclidine binding site". ''Neurotoxicol Teratol''. '''16''' (4): 343–53. doi:10.1016/0892-0362(94)90022-1. PMID 7968938.]</ref> PCP also acts as a sigma-2 agonist and mild serotonin reuptake inhibitor.<ref>[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602154/ Roth, Bryan L et al. “The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor.” ''PloS one'' vol. 8,3 (2013): e59334. doi:10.1371/journal.pone.0059334]</ref> It has also been characterized as a potent D2 dopamine agonist but not a dopamine reuptake inhibitor in humans.<ref>[https://pubmed.ncbi.nlm.nih.gov/19391150/ Seeman P, Guan HC, Hirbec H (2009). "Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil". ''Synapse''. '''63''' (8): 698–704. doi:10.1002/syn.20647. PMID 19391150. S2CID 17758902.]</ref> This D2 dopamine agonism contributes to the infamous stimulation, euphoria, and mania of PCP. | ||
==Subjective effects== | ==Subjective effects== | ||
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|{{effects/physical| | |{{effects/physical| | ||
*'''[[Effect::Stimulation]] | |||
*'''[[Effect::Pain relief]] | *'''[[Effect::Pain relief]] | ||
*'''[[Effect::Dizziness]]''' | *'''[[Effect::Dizziness]]''' | ||
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**'''[[Effect::Physical euphoria]]''' | **'''[[Effect::Physical euphoria]]''' | ||
*'''[[Effect::Tactile suppression]]''' | *'''[[Effect::Tactile suppression]]''' | ||
*'''[[Effect::Appetite | *'''[[Effect::Increased libido]]''' - Notably increased ejaculation strength | ||
*'''Effect::Bowel | *'''[[Effect::Appetite enhancement]]''' | ||
*'''Effect::Bowel movements''' | |||
}} | }} | ||