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Lisdexamfetamine: Difference between revisions
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===Conversion rate=== | ===Conversion rate=== | ||
29.7% of the weight of lisdexamfetamine dimesylate (the usual prescribed form) is dexamphetamine: 30 mg lisdexamfetamine dimesylate is equivalent to 8.9 mg of dexamfetamine.<ref>https://www.medicines.org.uk/emc/medicine/27442/SPC/</ref><ref> | 29.7% of the weight of lisdexamfetamine dimesylate (the usual prescribed form) is dexamphetamine: 30 mg lisdexamfetamine dimesylate is equivalent to 8.9 mg of dexamfetamine.<ref>https://www.medicines.org.uk/emc/medicine/27442/SPC/</ref><ref>https://39f93cda-b262-4d28-a694-bf36a6802943.filesusr.com/ugd/1da6d0_55267f5b04204cb58bcc848398c0286f.pdf</ref> | ||
The subjective experience will differ due to the slower, more steady release of active substance in the [[prodrug]]. An equivalent dose of dexamphetamine will have a higher peak plasma concentration and shorter duration. | The subjective experience will differ due to the slower, more steady release of active substance in the [[prodrug]]. An equivalent dose of dexamphetamine will have a higher peak plasma concentration and shorter duration. | ||
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*'''[[Effect::Stimulation]]''' - Lisdexamfetamine is reported to be very energetic and stimulating in a manner similar to [[amphetamine]]. It can encourage physical activities such as dancing, socializing, running, or cleaning. The particular style of stimulation which lisdexamfetamine produces can be described as forced. This means that, at higher dosages, it becomes difficult or impossible to keep still as jaw clenching, involuntary bodily shakes and vibrations become present, resulting in extreme shaking of the entire body, unsteadiness of the hands, and a general loss of fine motor control. This effect is replaced with mild fatigue and general exhaustion during the offset of the experience. | *'''[[Effect::Stimulation]]''' - Lisdexamfetamine is reported to be very energetic and stimulating in a manner similar to [[amphetamine]]. It can encourage physical activities such as dancing, socializing, running, or cleaning. The particular style of stimulation which lisdexamfetamine produces can be described as forced. This means that, at higher dosages, it becomes difficult or impossible to keep still as jaw clenching, involuntary bodily shakes and vibrations become present, resulting in extreme shaking of the entire body, unsteadiness of the hands, and a general loss of fine motor control. This effect is replaced with mild fatigue and general exhaustion during the offset of the experience. | ||
*'''[[Effect::Spontaneous bodily sensations]]''' - The "body high" of lisdexamphetamine can be described as a moderate euphoric tingling sensation that encompasses the entire body. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. | *'''[[Effect::Spontaneous bodily sensations]]''' - The "body high" of lisdexamphetamine can be described as a moderate euphoric tingling sensation that encompasses the entire body. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached. | ||
*'''[[Effect::Abnormal heartbeat]]''' | *'''[[Effect::Abnormal heartbeat]]'''{{citation needed}} | ||
*'''[[Effect::Increased heart rate]]'''<ref>Huang YS, Tsai MH (July 2011). "Long-term outcomes with medications for attention-deficit hyperactivity disorder: current status of knowledge". CNS Drugs. 25 (7): 539–554. doi:10.2165/11589380-000000000-00000. PMID 21699268</ref> | *'''[[Effect::Increased heart rate]]'''<ref>Huang YS, Tsai MH (July 2011). "Long-term outcomes with medications for attention-deficit hyperactivity disorder: current status of knowledge". CNS Drugs. 25 (7): 539–554. doi:10.2165/11589380-000000000-00000. PMID 21699268</ref> | ||
*'''[[Effect::Increased blood pressure]]''' | *'''[[Effect::Increased blood pressure]]'''{{citation needed}} | ||
*'''[[Effect::Appetite suppression]]''' - This effect is more pronounced compared to [[amphetamine]], sometimes causing people to not eat for the entire duration of action. Lisdexamfetamine is sometimes prescribed to treat binge eating disorder due to its strong appetite suppressing effect. | *'''[[Effect::Appetite suppression]]''' - This effect is more pronounced compared to [[amphetamine]], sometimes causing people to not eat for the entire duration of action. Lisdexamfetamine is sometimes prescribed to treat binge eating disorder due to its strong appetite suppressing effect. | ||
*'''[[Effect::Bronchodilation]]''' | *'''[[Effect::Bronchodilation]]''' | ||
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*'''[[Effect::Dry mouth]]''' | *'''[[Effect::Dry mouth]]''' | ||
*'''[[Effect::Frequent urination]]''' | *'''[[Effect::Frequent urination]]''' | ||
*'''[[Effect::Increased bodily temperature]]''' | *'''[[Effect::Increased bodily temperature]]'''{{citation needed}} | ||
*'''[[Effect::Increased perspiration]]''' | *'''[[Effect::Increased perspiration]]''' | ||
*'''[[Effect::Nausea]]''' - This effect usually only occurs at heavy doses. | *'''[[Effect::Nausea]]''' - This effect usually only occurs at heavy doses. | ||