This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
2C-B: Difference between revisions
>Josikins |
>Josikins No edit summary |
||
| Line 12: | Line 12: | ||
Unlike most [[psychedelics]], 2C-B has been shown to be a low efficacy [[serotonin]] 5-HT<sub>2A</sub> receptor [[Agonist#Agonists|partial agonist]]<ref>Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors | http://jpet.aspetjournals.org/content/321/3/1054</ref> or even full [[antagonist]].<ref>http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04 | http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04</ref> This suggests that the 5-HT<sub>2C</sub> receptor is primarily responsible for mediating the effects experienced by users of 2C-B. <ref>http://jpet.aspetjournals.org/content/321/3/1054.full.pdf</ref> Research also suggests that 2C-B increases [[dopamine]] levels in the brains of rats which may contribute to its psychoactivity.<ref>behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats | http://link.springer.com/article/10.1007%2Fs00213-012-2797-7</ref> However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive. | Unlike most [[psychedelics]], 2C-B has been shown to be a low efficacy [[serotonin]] 5-HT<sub>2A</sub> receptor [[Agonist#Agonists|partial agonist]]<ref>Functional Selectivity of Hallucinogenic Phenethylamine and Phenylisopropylamine Derivatives at Human 5-Hydroxytryptamine (5-HT)2A and 5-HT2C Receptors | http://jpet.aspetjournals.org/content/321/3/1054</ref> or even full [[antagonist]].<ref>http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04 | http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0705722/abstract;jsessionid=7F4731B4EF0AF36C37D0E3CA60319C4E.f03t04</ref> This suggests that the 5-HT<sub>2C</sub> receptor is primarily responsible for mediating the effects experienced by users of 2C-B. <ref>http://jpet.aspetjournals.org/content/321/3/1054.full.pdf</ref> Research also suggests that 2C-B increases [[dopamine]] levels in the brains of rats which may contribute to its psychoactivity.<ref>behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats | http://link.springer.com/article/10.1007%2Fs00213-012-2797-7</ref> However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive. | ||
=Subjective effects= | ==Subjective effects== | ||
==[[Physical effects - Psychedelics|Physical effects]]== | ===[[Physical effects - Psychedelics|Physical effects]]=== | ||
The physical effects of 2C-B can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include: | The physical effects of 2C-B can be broken down into five components all of which progressively intensify proportional to dosage. These are described below and generally include: | ||
| Line 22: | Line 22: | ||
*'''[[Physical effects: Enhancement of touch|Enhancement of touch]]''' | *'''[[Physical effects: Enhancement of touch|Enhancement of touch]]''' | ||
==[[Cognitive effects - Psychedelics|Cognitive effects]]== | ===[[Cognitive effects - Psychedelics|Cognitive effects]]=== | ||
The cognitive effects of 2C-B are often described by many as both insightful and relatively normal in their thought processes even at moderate to high dosages. | The cognitive effects of 2C-B are often described by many as both insightful and relatively normal in their thought processes even at moderate to high dosages. | ||