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Serotonergic psychedelic: Difference between revisions
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[[File:Lsd brain scan.jpg|thumbnail|315px|right|This image shows how, with eyes-closed, much more of the brain contributes to the visual experience under LSD (right image) than under placebo (left image). The magnitude of this effect correlates with participants’ reports of complex, dreamlike visions.<ref>Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L., Kaelen, M., Droog, W., Murphy, K., … Nutt, D. J. (2016). Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1518377113</ref>]] | [[File:Lsd brain scan.jpg|thumbnail|315px|right|This image shows how, with eyes-closed, much more of the brain contributes to the visual experience under LSD (right image) than under placebo (left image). The magnitude of this effect correlates with participants’ reports of complex, dreamlike visions.<ref>Carhart-Harris, R. L., Muthukumaraswamy, S., Roseman, L., Kaelen, M., Droog, W., Murphy, K., … Nutt, D. J. (2016). Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1518377113</ref>]] | ||
While the full mechanism of action is not understood, serotonergic psychedelics are known to exhibit | While the full mechanism of action is not understood, serotonergic psychedelics are known to exhibit [[partial agonism|partial agonist activity]] for various 5-HT receptors in a range of affinities and efficacies. As a result, they may be classified by their activity at different 5-HT sub-sites, such as 5-HT<sub>1A</sub>, 5-HT<sub>1B</sub>, 5-HT<sub>2A</sub>, etc. | ||
Many serotonergic psychedelics, such as the family of [[tryptamines]], have very strong structural similarities to serotonin itself. This partially explains the affinity they have for certain 5-HT sites. Most research suggests that the signature psychedelic effect is due to strong partial [[agonist]] activity at the 5-HT<sub>2A</sub>, and to a lesser extent, 5-HT<sub>2C</sub> and 5-HT<sub>1A</sub> receptors.{{citation needed}} | Many serotonergic psychedelics, such as the family of [[tryptamines]], have very strong structural similarities to serotonin itself. This partially explains the affinity they have for certain 5-HT sites. Most research suggests that the signature psychedelic effect is due to strong partial [[agonist]] activity at the 5-HT<sub>2A</sub>, and to a lesser extent, 5-HT<sub>2C</sub> and 5-HT<sub>1A</sub> receptors.{{citation needed}} | ||