Talk:Cabergoline: Difference between revisions

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'''Cabergoline''' is a chemical of the [[lysergamide]] and ergopeptine classes. It is a derivative of [[LSD]] or more specifically [[AL-LAD]] and shares many effects with related, non-psychedelic compounds such as [[ergotamine]], ergonovine or [[lisuride]]. It is occasionally prescribed to treat symptoms of high prolactin levels and managing Parkinson's disease.

Cabergoline is not predominantly psychedelic ~~but rather~~ exerts its effects ~~strongest~~ at the [[dopamine]] D2 receptor as an agonist ~~and~~ comparatively little on the [[serotonin]] 5-HT2A receptor, as a partial agonist.

Cabergoline is not predominantly psychedelic, it exerts its effects at the [[dopamine]] D2 receptor as an agonist but has comparatively little effect on the [[serotonin]] 5-HT2A receptor where it acts as a partial agonist.

Cabergoline has little recreational value ~~exclusively due to~~ its unique property of reducing or eliminating the male refractory period, thereby allowing men to experience multiple ejaculatory orgasms in rapid succession.<ref>Krüger TH, Haake P, Haverkamp J, et al. (December 2003). "Effects of acute prolactin manipulation on sexual drive and function in males". Journal of Endocrinology. 179 (3): 357–65. CiteSeerX 10.1.1.484.4005. doi:10.1677/joe.0.1790357. PMID 14656205.</ref><ref>Hollander, Adam B.; Pastuszak, Alexander W.; Lipshultz, Larry I. (2016). "Cabergoline in the Treatment of Male Orgasmic Disorder—A Retrospective Pilot Analysis". Journal of Sexual Medicine. 4 (4): e28–e33. doi:10.1016/j.esxm.2015.09.001. PMC 4822480. PMID 26944776.</ref>

Cabergoline has little recreational value other than its unique property of reducing or eliminating the male refractory period, thereby allowing men to experience multiple ejaculatory orgasms in rapid succession.<ref>Krüger TH, Haake P, Haverkamp J, et al. (December 2003). "Effects of acute prolactin manipulation on sexual drive and function in males". Journal of Endocrinology. 179 (3): 357–65. CiteSeerX 10.1.1.484.4005. doi:10.1677/joe.0.1790357. PMID 14656205.</ref><ref>Hollander, Adam B.; Pastuszak, Alexander W.; Lipshultz, Larry I. (2016). "Cabergoline in the Treatment of Male Orgasmic Disorder—A Retrospective Pilot Analysis". Journal of Sexual Medicine. 4 (4): e28–e33. doi:10.1016/j.esxm.2015.09.001. PMC 4822480. PMID 26944776.</ref>

==See also==

*[[Responsible use]]

*[[Lysergamide]]

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==External links==

*[https://en.wikipedia.org/wiki/Cabergoline Cabergoline (Wikipedia)]

*[https://isomerdesign.com/PiHKAL/explore.php?id=9594&name=Cabergoline Cabergoline (Isomer Design)]

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[[Category:Alkaloid]]

[[Category:Lysergamide]]

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 '''Cabergoline''' is a chemical of the [[lysergamide]] and ergopeptine classes. It is a derivative of [[LSD]] or more specifically [[AL-LAD]] and shares many effects with related, non-psychedelic compounds such as [[ergotamine]], ergonovine or [[lisuride]]. It is occasionally prescribed to treat symptoms of high prolactin levels and managing Parkinson's disease.
-Cabergoline is not predominantly psychedelic but rather exerts its effects strongest at the [[dopamine]] D<sub>2</sub> receptor as an agonist and comparatively little on the [[serotonin]] 5-HT<sub>2A</sub> receptor, as a partial agonist.
+Cabergoline is not predominantly psychedelic, it exerts its effects at the [[dopamine]] D<sub>2</sub> receptor as an agonist but has comparatively little effect on the [[serotonin]] 5-HT<sub>2A</sub> receptor where it acts as a partial agonist.
-Cabergoline has little recreational value exclusively due to its unique property of reducing or eliminating the male refractory period, thereby allowing men to experience multiple ejaculatory orgasms in rapid succession.<ref>Krüger TH, Haake P, Haverkamp J, et al. (December 2003). "Effects of acute prolactin manipulation on sexual drive and function in males". Journal of Endocrinology. 179 (3): 357–65. CiteSeerX 10.1.1.484.4005. doi:10.1677/joe.0.1790357. PMID 14656205.</ref><ref>Hollander, Adam B.; Pastuszak, Alexander W.; Lipshultz, Larry I. (2016). "Cabergoline in the Treatment of Male Orgasmic Disorder—A Retrospective Pilot Analysis". Journal of Sexual Medicine. 4 (4): e28–e33. doi:10.1016/j.esxm.2015.09.001. PMC 4822480. PMID 26944776.</ref>
+Cabergoline has little recreational value other than its unique property of reducing or eliminating the male refractory period, thereby allowing men to experience multiple ejaculatory orgasms in rapid succession.<ref>Krüger TH, Haake P, Haverkamp J, et al. (December 2003). "Effects of acute prolactin manipulation on sexual drive and function in males". Journal of Endocrinology. 179 (3): 357–65. CiteSeerX 10.1.1.484.4005. doi:10.1677/joe.0.1790357. PMID 14656205.</ref><ref>Hollander, Adam B.; Pastuszak, Alexander W.; Lipshultz, Larry I. (2016). "Cabergoline in the Treatment of Male Orgasmic Disorder—A Retrospective Pilot Analysis". Journal of Sexual Medicine. 4 (4): e28–e33. doi:10.1016/j.esxm.2015.09.001. PMC 4822480. PMID 26944776.</ref>
 ==See also==
 *[[Responsible use]]
 *[[Lysergamide]]
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 ==External links==
 *[https://en.wikipedia.org/wiki/Cabergoline Cabergoline (Wikipedia)]
 *[https://isomerdesign.com/PiHKAL/explore.php?id=9594&name=Cabergoline Cabergoline (Isomer Design)]
@@ Line 20: / Line 22: @@
 [[Category:Alkaloid]]
 [[Category:Lysergamide]]
+<references />