2C-B: Difference between revisions

Line 2:

'''4-Bromo-2,5-dimethoxyphenethylamine''' (also known as '''Nexus''', '''Bromo Mescaline''', '''BDMPEA''', '''Venus''', and '''2C-B''') is a novel [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] class.

It is the most well-known member of the [[2C-x family]] of psychedelic phenethylamines, which are chemically related to the classical psychedelic [[mescaline]]. ~~2C-B~~ is thought to produce its effects ~~through activity at~~ [[serotonin]] [[receptors]] in the brain; however, the precise mechanism of action is not known.

It is the most well-known member of the [[2C-x family]] of psychedelic phenethylamines, which are chemically related to the classical psychedelic [[mescaline]]. It is thought to produce its effects by binding to [[serotonin]] [[receptors]] in the brain; however, the precise mechanism of action is not known.

2C-B was discovered in 1974 by the American chemist [[Alexander Shulgin]], who documented its synthesis and subjective effects in the 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal020.shtml|chapter=#20. 2C-B}}</ref><ref>{{cite journal|last1=Shulgin|first1=A. T.|author-link1=Alexander Shulgin|last2=Carter|first2=M. F.|title=Centrally active phenethylamines|journal=Psychopharmacology Communications|year=1975|volume=1|issue=1|pages=93–98|pmid=1223994|issn=0098-616X|oclc=924603662}}</ref>

In the 1970s, it ~~was used~~ as a therapeutic aid by a small circle of American psychotherapists; it was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.<ref>{{cite web|title=2C-B: Effects|url=http://www.erowid.org/chemicals/2cb/2cb_effects.shtml|publisher=Erowid|access-date=February 10, 2020|orig-year=Modified 2015|date=February 12, 1998}}</ref>

In the 1970s, it first saw use as a therapeutic aid by a small circle of American psychotherapists; it was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.<ref>{{cite web|title=2C-B: Effects|url=http://www.erowid.org/chemicals/2cb/2cb_effects.shtml|publisher=Erowid|access-date=February 10, 2020|orig-year=Modified 2015|date=February 12, 1998}}</ref>

It entered into recreational use shortly afterward and was briefly manufactured and sold commercially under such names as "Eros" and "Nexus" in "head" / "smart" shops and adult video stores before becoming federally prohibited in 1995.<ref name="DEA2001">{{cite web|title=2C-B (Nexus) Reappears on the Club Drug Scene|url=http://www.justice.gov/archive/ndic/pubs0/665/665p.pdf|work=Information Bulletin|date=May 2001|publisher=Drug Enforcement Agency (DEA)|id=2001-L0424-002}}</ref>

[[Subjective effects]] include [[geometry|open and closed-eye visuals]], [[time distortion]], [[euphoria]], and [[ego loss]]. User reports have described the effects of 2C-B as moderate, warm, colorful, and highly sensual. Similar to [[mescaline]], it is described as possessing a less serious or grandiose headspace than [[tryptamines]] like [[LSD]] or [[psilocybin mushrooms]] and exhibiting a greater emphasis on visual and tactile effects. Smaller doses (under 15 mg) can be used as a sensory and aesthetic enhancer (in a manner somewhat similar to [[MDMA]]) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect.

[[Subjective effects]] include [[geometry|open and closed-eye visuals]], [[time distortion]], [[euphoria]], and [[ego loss]]. User reports have described the effects of 2C-B as moderate, warm, colorful, and highly sensual. Similar to [[mescaline]], it is described as possessing a less serious or grandiose headspace than [[tryptamines]] like [[LSD]] or [[psilocybin mushrooms]], and exhibiting a greater emphasis on visual and tactile effects. Smaller doses (under 15 mg) can be used as a sensory and aesthetic enhancer (in a manner somewhat similar to [[MDMA]]) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect.

2C-B is considered to be physiologically well-tolerated and likely has a safety profile similar to classical psychedelics, which are known to have low toxicity. However, more research is needed to fully understand ~~its~~ potential toxicity and ~~health risks~~. It is highly advised to use [[harm reduction practices]] if using this substance.

2C-B is considered to be physiologically well-tolerated and likely has a safety profile similar to classical psychedelics, which are known to have low abuse potential and toxicity. However, more research is needed to fully understand the potential toxicity and harm potential of this substance. It is highly advised to use [[harm reduction practices]] if using this substance.

==History and culture==

@@ Line 2: / Line 2: @@
 {{SubstanceBox/2C-B}}
 '''4-Bromo-2,5-dimethoxyphenethylamine''' (also known as '''Nexus''', '''Bromo Mescaline''', '''BDMPEA''', '''Venus''', and '''2C-B''') is a novel [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] class.
-It is the most well-known member of the [[2C-x family]] of psychedelic phenethylamines, which are chemically related to the classical psychedelic [[mescaline]]. 2C-B is thought to produce its effects through activity at [[serotonin]] [[receptors]] in the brain; however, the precise mechanism of action is not known.
+It is the most well-known member of the [[2C-x family]] of psychedelic phenethylamines, which are chemically related to the classical psychedelic [[mescaline]]. It is thought to produce its effects by binding to [[serotonin]] [[receptors]] in the brain; however, the precise mechanism of action is not known.
 C-B was discovered in 1974 by the American chemist [[Alexander Shulgin]], who documented its synthesis and subjective effects in the 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal020.shtml|chapter=#20. 2C-B}}</ref><ref>{{cite journal|last1=Shulgin|first1=A. T.|author-link1=Alexander Shulgin|last2=Carter|first2=M. F.|title=Centrally active phenethylamines|journal=Psychopharmacology Communications|year=1975|volume=1|issue=1|pages=93–98|pmid=1223994|issn=0098-616X|oclc=924603662}}</ref>
-In the 1970s, it was used as a therapeutic aid by a small circle of American psychotherapists; it was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.<ref>{{cite web|title=2C-B: Effects|url=http://www.erowid.org/chemicals/2cb/2cb_effects.shtml|publisher=Erowid|access-date=February 10, 2020|orig-year=Modified 2015|date=February 12, 1998}}</ref>
+In the 1970s, it first saw use as a therapeutic aid by a small circle of American psychotherapists; it was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.<ref>{{cite web|title=2C-B: Effects|url=http://www.erowid.org/chemicals/2cb/2cb_effects.shtml|publisher=Erowid|access-date=February 10, 2020|orig-year=Modified 2015|date=February 12, 1998}}</ref>
 It entered into recreational use shortly afterward and was briefly manufactured and sold commercially under such names as "Eros" and "Nexus" in "head" / "smart" shops and adult video stores before becoming federally prohibited in 1995.<ref name="DEA2001">{{cite web|title=2C-B (Nexus) Reappears on the Club Drug Scene|url=http://www.justice.gov/archive/ndic/pubs0/665/665p.pdf|work=Information Bulletin|date=May 2001|publisher=Drug Enforcement Agency (DEA)|id=2001-L0424-002}}</ref>
-[[Subjective effects]] include [[geometry|open and closed-eye visuals]], [[time distortion]], [[euphoria]], and [[ego loss]]. User reports have described the effects of 2C-B as moderate, warm, colorful, and highly sensual. Similar to [[mescaline]], it is described as possessing a less serious or grandiose headspace than [[tryptamines]] like [[LSD]] or [[psilocybin mushrooms]] and exhibiting a greater emphasis on visual and tactile effects. Smaller doses (under 15 mg) can be used as a sensory and aesthetic enhancer (in a manner somewhat similar to [[MDMA]]) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect.
+[[Subjective effects]] include [[geometry|open and closed-eye visuals]], [[time distortion]], [[euphoria]], and [[ego loss]]. User reports have described the effects of 2C-B as moderate, warm, colorful, and highly sensual. Similar to [[mescaline]], it is described as possessing a less serious or grandiose headspace than [[tryptamines]] like [[LSD]] or [[psilocybin mushrooms]], and exhibiting a greater emphasis on visual and tactile effects. Smaller doses (under 15 mg) can be used as a sensory and aesthetic enhancer (in a manner somewhat similar to [[MDMA]]) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect.
-C-B is considered to be physiologically well-tolerated and likely has a safety profile similar to classical psychedelics, which are known to have low toxicity. However, more research is needed to fully understand its potential toxicity and health risks. It is highly advised to use [[harm reduction practices]] if using this substance.
+C-B is considered to be physiologically well-tolerated and likely has a safety profile similar to classical psychedelics, which are known to have low abuse potential and toxicity. However, more research is needed to fully understand the potential toxicity and harm potential of this substance. It is highly advised to use [[harm reduction practices]] if using this substance.
 ==History and culture==