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2C-B: Difference between revisions
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'''4-Bromo-2,5-dimethoxyphenethylamine''' (also known as '''Nexus''', '''Bromo Mescaline''', '''BDMPEA''', '''Venus''', and '''2C-B''') is a novel [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] class. | '''4-Bromo-2,5-dimethoxyphenethylamine''' (also known as '''Nexus''', '''Bromo Mescaline''', '''BDMPEA''', '''Venus''', and '''2C-B''') is a novel [[Psychoactive class::psychedelic]] substance of the [[chemical class::phenethylamine]] class. | ||
It is the most well-known member of the [[2C-x family]] of psychedelic phenethylamines, which are chemically | It is the most well-known member of the [[2C-x family]] of psychedelic phenethylamines, which are chemically related to the classical psychedelic [[mescaline]]. 2C-B is thought to produce its effects through activity at [[serotonin]] [[receptors]] in the brain; however, the precise mechanism of action is not known. | ||
2C-B was discovered in 1974 by the American chemist [[Alexander Shulgin]], who documented its synthesis and subjective effects in | 2C-B was discovered in 1974 by the American chemist [[Alexander Shulgin]], who documented its synthesis and subjective effects in the 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref name="PiHKAL">{{cite book|title=PiHKAL: A Chemical Love Story|title-link=PiHKAL|author-link1=Alexander Shulgin|author1=Alexander Shulgin|author2=Ann Shulgin|year=1991|publisher=Transform Press|location=United States|isbn=0963009605|oclc=1166889264|chapter-url=https://erowid.org/library/books_online/pihkal/pihkal020.shtml|chapter=#20. 2C-B}}</ref><ref>{{cite journal|last1=Shulgin|first1=A. T.|author-link1=Alexander Shulgin|last2=Carter|first2=M. F.|title=Centrally active phenethylamines|journal=Psychopharmacology Communications|year=1975|volume=1|issue=1|pages=93–98|pmid=1223994|issn=0098-616X|oclc=924603662}}</ref> | ||
In the 1970s, it was used | In the 1970s, it was used as a therapeutic aid by a small circle of American psychotherapists; it was considered one of the best substances for this purpose due to its short duration, relative absence of side effects, and comparably mild nature.<ref>{{cite web|title=2C-B: Effects|url=http://www.erowid.org/chemicals/2cb/2cb_effects.shtml|publisher=Erowid|access-date=February 10, 2020|orig-year=Modified 2015|date=February 12, 1998}}</ref> | ||
It entered into recreational use shortly afterward and was manufactured and sold commercially under names | It entered into recreational use shortly afterward and was briefly manufactured and sold commercially under such names as "Eros" and "Nexus" in "head" / "smart" shops and adult video stores before becoming federally prohibited in 1995.<ref name="DEA2001">{{cite web|title=2C-B (Nexus) Reappears on the Club Drug Scene|url=http://www.justice.gov/archive/ndic/pubs0/665/665p.pdf|work=Information Bulletin|date=May 2001|publisher=Drug Enforcement Agency (DEA)|id=2001-L0424-002}}</ref> | ||
[[Subjective effects]] include [[geometry|open and closed-eye visuals]], [[time distortion]], [[euphoria]], and [[ego loss]]. User reports have described the effects of 2C-B as moderate, warm, colorful, and highly sensual. Similar to mescaline, it is described as possessing a less serious or grandiose headspace than [[LSD]] or | [[Subjective effects]] include [[geometry|open and closed-eye visuals]], [[time distortion]], [[euphoria]], and [[ego loss]]. User reports have described the effects of 2C-B as moderate, warm, colorful, and highly sensual. Similar to [[mescaline]], it is described as possessing a less serious or grandiose headspace than [[tryptamines]] like [[LSD]] or [[psilocybin mushrooms]] and exhibiting a greater emphasis on visual and tactile effects. Smaller doses (under 15 mg) can be used as a sensory and aesthetic enhancer (in a manner somewhat similar to [[MDMA]]) while larger doses are reported to produce a distinct mind-manifesting psychedelic effect. | ||
2C-B is considered to be physiologically well-tolerated and likely has a safety profile similar to classical psychedelics | 2C-B is considered to be physiologically well-tolerated and likely has a safety profile similar to classical psychedelics, which are known to have low toxicity. However, more research is needed to fully understand its potential toxicity and health risks. It is highly advised to use [[harm reduction practices]] if using this substance. | ||
==History and culture== | ==History and culture== | ||
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Tolerance to the effects of 2C-B is not built almost immediately after ingestion. There are many anecdotal reports of people ingesting this substance many days in a row (either consecutively or by redosing many many times in a row and tripping continuously for dozens of hours) with no immediate tolerance build up and still building quite slowly even under sustained exposure. | Tolerance to the effects of 2C-B is not built almost immediately after ingestion. There are many anecdotal reports of people ingesting this substance many days in a row (either consecutively or by redosing many many times in a row and tripping continuously for dozens of hours) with no immediate tolerance build up and still building quite slowly even under sustained exposure. | ||
2C-B does not produce cross-tolerance with other serotonergic psychedelics, although most users report other psychedelics affecting 2C-B tolerance. For example 2C-B followed by LSD will not result in any loss of effects whereas LSD followed by 2C-B will. Others report 2C-B following a completely separate tolerance clock to other psychedelics with no cross tolerance being shared between the two, although this seems to be a rare reaction with that individual's personal body chemistry, with the aforementioned one-way tolerance being the case for the very large majority of the p | 2C-B does not produce cross-tolerance with other serotonergic psychedelics, although most users report other psychedelics affecting 2C-B tolerance. For example 2C-B followed by LSD will not result in any loss of effects whereas LSD followed by 2C-B will. Others report 2C-B following a completely separate tolerance clock to other psychedelics with no cross tolerance being shared between the two, although this seems to be a rare reaction with that individual's personal body chemistry, with the aforementioned one-way tolerance being the case for the very large majority of the p | ||