HXE: Difference between revisions

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3-HO-2'-Oxo-PCE (commonly known as HXE) is a [[dissociative]] substance of the [[arylcyclohexylamine]] class that produces [[ketamine]]-like [[dissociative]] effects when [[administered]]. It is structurally related to [[Methoxetamine]],[[Ketamine]] and [[PCE]].

'''3-HO-2'-Oxo-PCE''' (commonly known as '''HXE''') is a novel [[dissociative]] substance of the [[arylcyclohexylamine]] class that produces [[ketamine]]-like [[dissociative]] effects when [[administered]]. It is structurally related to [[Methoxetamine]], [[Ketamine]] and [[PCE]].

Limited data exists about the pharmacological properties, metabolism, and toxicity of HXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.

==History and culture==

HXE first appeared for sale on the online research chemical market in late 2020.

HXE first appeared for sale on the online research chemical market in late 2020. However, it has been announced about three years prior where it has been 'hyped' for a long time but was on hold due to synthesis difficulties.{{citation needed}}

==Chemistry==

HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an Arylcyclohexylamine

HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an [[Arylcyclohexylamine]]

It is substituted on the cyclohexane ring with an oxygen at the 2' position and a hydroxy group at the 3 position on the phenyl ring. In contrast, [[MXE]] is substituted there with a methoxy group.

==Pharmacology==

Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”

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HXE's effects resemble rather the effects of [[MXPr]], [[MXE]], [[DCK]] than more chaotic derivatives like [[O-PCE]] or [[MXiPr]]. Compared to [[MXE]], it has less of a warmth to it and is weaker in its euphoria and clearheadedness.

{{effects/base

|{{effects/physical|

~~If applicable, a brief paragraph summary of the substance's physical effects may be included here.~~

~~You may select physical effects to add below [[Subjective effect index#Physical effects|here]].~~

*'''[[Effect::~~Physical effect~~]]'''

*'''[[Effect::Stimulation]]''' or '''[[Effect::Sedation]]''' -

*'''[[Effect::Physical effect2]]'''

*'''[[Effect::Physical effect3]]'''

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-<!-- Please ensure that any new substance articles are first published in the 'Talk' namespace. For example, a new article on substance XYZ should have the title "Talk: XYZ" instead of "XYZ". Once the submitted article has been reviewed and determined to meet the guidelines and standards, it will be published by a staff member. -->
--HO-2'-Oxo-PCE (commonly known as HXE) is a [[dissociative]] substance of the [[arylcyclohexylamine]] class that produces [[ketamine]]-like [[dissociative]] effects when [[administered]]. It is structurally related to [[Methoxetamine]],[[Ketamine]] and [[PCE]].
+'''3-HO-2'-Oxo-PCE''' (commonly known as '''HXE''') is a novel [[dissociative]] substance of the [[arylcyclohexylamine]] class that produces [[ketamine]]-like [[dissociative]] effects when [[administered]]. It is structurally related to [[Methoxetamine]], [[Ketamine]] and [[PCE]].
 Limited data exists about the pharmacological properties, metabolism, and toxicity of HXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.
 ==History and culture==
-HXE first appeared for sale on the online research chemical market in late 2020.
+HXE first appeared for sale on the online research chemical market in late 2020. However, it has been announced about three years prior where it has been 'hyped' for a long time but was on hold due to synthesis difficulties.{{citation needed}}
 ==Chemistry==
-HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an Arylcyclohexylamine
+HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an [[Arylcyclohexylamine]]
+It is substituted on the cyclohexane ring with an oxygen at the 2' position and a hydroxy group at the 3 position on the phenyl ring. In contrast, [[MXE]] is substituted there with a methoxy group.
 ==Pharmacology==
 Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”
@@ Line 246: / Line 248: @@
 {{EffectStub}}
 {{Preamble/SubjectiveEffects}}
+HXE's effects resemble rather the effects of [[MXPr]], [[MXE]], [[DCK]] than more chaotic derivatives like [[O-PCE]] or [[MXiPr]]. Compared to [[MXE]], it has less of a warmth to it and is weaker in its euphoria and clearheadedness.
 {{effects/base
 |{{effects/physical|
-If applicable, a brief paragraph summary of the substance's physical effects may be included here.
-You may select physical effects to add below [[Subjective effect index#Physical effects|here]].
-*'''[[Effect::Physical effect]]'''
+*'''[[Effect::Stimulation]]''' or '''[[Effect::Sedation]]''' -
 *'''[[Effect::Physical effect2]]'''
 *'''[[Effect::Physical effect3]]'''