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Talk:Loperamide: Difference between revisions
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>Azed Revised status of Loperamide availability |
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==History and culture== | ==History and culture== | ||
Loperamide is a phenylpiperidine derivative, [[opioid]] [[agonist]] thought to have a low potential for central nervous effects. It was launched by Janssen Pharmaceutica in 1973. On release loperamide was classified in the US as a schedule II narcotic, before transfer to to schedule V in 1977. In November 1982 loperamide was removed from schedule V or 'decontrolled'. | Loperamide is a phenylpiperidine derivative, [[opioid]] [[agonist]] thought to have a low potential for central nervous effects. It was launched by Janssen Pharmaceutica in 1973. On release loperamide was classified in the US as a schedule II narcotic, before transfer to to schedule V in 1977. In November 1982 loperamide was removed from schedule V or 'decontrolled' and made available over-the-counter. | ||
This appears to have been based on initial, preclinical studies indicative of dependence and [[withdrawal]] in animal studies. The consensus of later studies was that loperamide has a low potential for abuse, based on an apparent lack of central nervous effects. | This appears to have been based on initial, preclinical studies indicative of dependence and [[withdrawal]] in animal studies. The consensus of later studies was that loperamide has a low potential for abuse, based on an apparent lack of central nervous effects. | ||