Pregabalin: Difference between revisions

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==Chemistry==

Pregabalin is a structural analog of [[GABA]] (gamma-aminobutyric acid), with an isobutyl group substituted on the beta carbon of the aminobutyric chain. Pregabalin is similar in structure to other [[Gabapentinoid|gabapentinoids]], such as [[gabapentin]] and [[phenibut]]. Pregabalin contains a carboxylated chain of hexane called hexanoic acid. This carbon chain is substituted with an amine group through a methyl bridge in (S) conformation at R<sub>3</sub> and a methyl group at R<sub>5</sub>.

==Pharmacology==

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*'''[[Effect::Drifting]]'''

*'''[[Effect::After images]]''' and *'''[[Effect::Frame rate suppression]]''' at high / very high doses. These 2 effects together can make your vision feel more 'slow'.

*'''[[Effect::Double vision]]'' - This effect is quite mild and inconsistently appears at high doses. Sleep deprivation might magnify this effect.

*'''[[Effect::Double vision]]'''- This effect is quite mild and inconsistently appears at high doses. Sleep deprivation might magnify this effect.

====Hallucinatory states====

While Pregabalin isn't commonly thought off as a ''trip'' drug, it still can cause ~~dissocative~~ and even psychotic like effects at higher doses. Sleep deprivation and genetics might play a roll into the hallucinatory states of Pregabalin. Pregabalin's hallucinatory states are (but not limited to) :

While Pregabalin isn't commonly thought off as a ''trip'' drug, it still can cause dissociative and even psychotic like effects at higher doses. Sleep deprivation and genetics might play a roll into the hallucinatory states of Pregabalin. Pregabalin's hallucinatory states are (but not limited to) :

*'''[[Effect::Internal hallucination]]''' - At high dosages, one may experience dream-like states and [[hypnagogia]].

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}}

{{effects/disconnective|

*'''[[Effect::Visual disconnection]]''' - This effect is generally quite mild and appears inconsistently at high doses. It results in feeling as if one's sense of vision is distant or vague and being viewed through a screen or window. However, ~~pregabalin~~ is rarely reported to cause [[holes, spaces and voids]] or [[Visual_disconnection#Structures|hallucinatory structures]] , it can in some users (sleep deprivation might enhance this effect) but it is far from the typical experience. Pressing on your eyes while sitting in a dark room on a high - very high dose may result in very mild [[structures]] and [[sceneries]]

*'''[[Effect::Visual disconnection]]''' - This effect is generally quite mild and appears inconsistently at high doses. It results in feeling as if one's sense of vision is distant or vague and being viewed through a screen or window. However, Pregabalin is rarely reported to cause [[holes, spaces and voids]] or [[Visual_disconnection#Structures|hallucinatory structures]] , it can in some users (sleep deprivation might enhance this effect) but it is far from the typical experience. Pressing on your eyes while sitting in a dark room on a high - very high dose may result in very mild [[structures]] and [[sceneries]]

}}

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*'''[[Effect::Disinhibition]]'''

*'''[[Effect::Dream potentiation]]'''

*'''[[Effect::Increased music appreciation]]''' - The music ~~enhancement~~ from ~~pregabalin~~ can be described as music sounding more detailed, 'higher quality', and even slowed down on higher dosages.

*'''[[Effect::Increased music appreciation]]''' - The music enhancment from Pregabalin can be described as music sounding more detailed, 'higher quality', and even slowed down on higher dosages.

*'''[[Effect::Motivation enhancement]]''' - Like [[kratom]], pregabalin can be mildly sedative yet increase motivation in a [[stimulant]]-like fashion.

*'''[[Effect::Immersion enhancement]]'''

*'''[[Effect::Creativity enhancement]]''' - This effect is especially noticeable on higher doses.

*'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At high/heavy doses, ~~pregabalin~~ can induce a mild dissociative state. The DPDR from Pregabalin can be increased and made more ''negative'' (~~less euphoric~~) by sleep deprivation.

*'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At high/heavy doses, Pregabalin can induce a mild dissociative state. The DPDR from Pregabalin can be increased and made more ''negative'' (dysphoric) by sleep deprivation.

*'''[[Effect::Suicidal ideation]]''' - In very huge doses this effect can lead to suicide attempts, sleep deprivation may increase this effect.

*'''[[Effect::Psychosis]]''' - Even at medicinal doses, ~~pregabalin~~ has been shown to have psychotic side effects in minority of it's users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia.

*'''[[Effect::Psychosis]]''' - Even at medicinal doses, Pregabalin has been shown to have psychotic side effects in minority of it's users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia.

*'''[[Effect::Mania]]''' - Even if ~~pregabalin~~ is used to treat bipolar disorder <ref> https://pubmed.ncbi.nlm.nih.gov/23040739/ </ref>,it can cause mania (even in medical doses in certain cases). <ref>https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12012 </ref>. In recreational settings, in high / very high recreational doses or/ and when the user is sleep deprived , this effect can occur, but its still not a part of the typical Pregabalin experience, this effect can be low in intensity (hypomania) or go hand in hand with [[Psychosis]] and appear as a full blown manic psychosis. It is important to acknowledge this effect is very, very rare.

*'''[[Effect::Mania]]''' - Even if Pregabalin is used to treat bipolar disorder <ref> https://pubmed.ncbi.nlm.nih.gov/23040739/ </ref>,it can cause mania (even in medical doses in certain cases). <ref>https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12012 </ref>. In recreational settings, in high / very high recreational doses or/ and when the user is sleep deprived , this effect can occur, but its still not a part of the typical Pregabalin experience, this effect can be low in intensity (hypomania) or go hand in hand with [[Psychosis]] and appear as a full blown manic psychosis. It is important to acknowledge this effect is very, very rare.

*'''[[Effect::Thought deceleration]]'''

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}}

{{effects/aftereffects|

The effects during a [[offset]] of an [[Pregabalin]] experience are generally ~~posetive~~ and more similar to an 'afterglow' rather then a 'hangover'. These effects are ~~ussaly~~ very mild compared to [[peak]] effects. The after effects of [[Pregabalin]] are:

The effects during a [[offset]] of an [[Pregabalin]] experience are generally positive and more similar to an 'afterglow' rather then a 'hangover'. These effects are usually very mild compared to [[peak]] effects. The after effects of [[Pregabalin]] are:

*'''[[Effect::Motivation enhancement]]''' - Pregabalin is usually mentally stimulating, and the ''afterglow'' is similar. Since the high is mostly gone, this can lead to productivity enhancement.

*'''[[Effect::Increased music appreciation]]''' - This effect is not as strong as it would be in the high, but music is noticeably enhanced and sounds more detailed.

@@ Line 11: / Line 11: @@
 ==Chemistry==
-Pregabalin is a structural analog of [[GABA]] (gamma-aminobutyric acid), with an isobutyl group substituted on the beta carbon of the aminobutyric chain. Pregabalin is similar in structure to other [[Gabapentinoid|gabapentinoids]], such as [[gabapentin]] and [[phenibut]]. Pregabalin contains a carboxylated chain of hexane called hexanoic acid. This carbon chain is substituted with an amine group through a methyl bridge in (S) conformation at R<sub>3</sub> and a methyl group at R<sub>5</sub>.
+Pregabalin is a structural analog of [[GABA]] (gamma-aminobutyric acid), with an isobutyl group substituted on the beta carbon of the aminobutyric chain. Pregabalin is similar in structure to other [[Gabapentinoid|gabapentinoids]], such as [[gabapentin]] and [[phenibut]].  Pregabalin contains a carboxylated chain of hexane called hexanoic acid. This carbon chain is substituted with an amine group through a methyl bridge in (S) conformation at R<sub>3</sub> and a methyl group at R<sub>5</sub>.
 ==Pharmacology==
@@ Line 64: / Line 64: @@
 *'''[[Effect::Drifting]]'''
 *'''[[Effect::After images]]''' and *'''[[Effect::Frame rate suppression]]'''  at high / very high doses. These 2 effects together can make your vision feel more 'slow'.
-*'''[[Effect::Double vision]]'' - This effect is quite mild and inconsistently appears at high doses. Sleep deprivation might magnify this effect.
+*'''[[Effect::Double vision]]'''- This effect is quite mild and inconsistently appears at high doses. Sleep deprivation might magnify this effect.
 ====Hallucinatory states====
-While Pregabalin isn't commonly thought off as a ''trip'' drug, it still can cause dissocative and even psychotic like effects at higher doses. Sleep deprivation and genetics might play a roll into the hallucinatory states of Pregabalin. Pregabalin's hallucinatory states are (but not limited to) :
+While Pregabalin isn't commonly thought off as a ''trip'' drug, it still can cause dissociative and even psychotic like effects at higher doses. Sleep deprivation and genetics might play a roll into the hallucinatory states of Pregabalin. Pregabalin's hallucinatory states are (but not limited to) :
 *'''[[Effect::Internal hallucination]]''' - At high dosages, one may experience dream-like states and [[hypnagogia]].
@@ Line 72: / Line 72: @@
 }}
 {{effects/disconnective|
-*'''[[Effect::Visual disconnection]]''' - This effect is generally quite mild and appears inconsistently at  high doses. It results in feeling as if one's sense of vision is distant or vague and being viewed through a screen or window. However, pregabalin is rarely reported to cause  [[holes, spaces and voids]] or [[Visual_disconnection#Structures|hallucinatory structures]] , it can in some users (sleep deprivation might enhance this effect) but it is far from the typical experience. Pressing on your eyes while sitting in a dark room on a high - very high dose may result in very  mild [[structures]] and [[sceneries]]
+*'''[[Effect::Visual disconnection]]''' - This effect is generally quite mild and appears inconsistently at  high doses. It results in feeling as if one's sense of vision is distant or vague and being viewed through a screen or window. However, Pregabalin is rarely reported to cause  [[holes, spaces and voids]] or [[Visual_disconnection#Structures|hallucinatory structures]] , it can in some users (sleep deprivation might enhance this effect) but it is far from the typical experience. Pressing on your eyes while sitting in a dark room on a high - very high dose may result in very  mild [[structures]] and [[sceneries]]
 }}
@@ Line 88: / Line 88: @@
 *'''[[Effect::Disinhibition]]'''
 *'''[[Effect::Dream potentiation]]'''
-*'''[[Effect::Increased music appreciation]]''' - The music enhancement from pregabalin can be described as music sounding more detailed, 'higher quality', and even slowed  down on higher dosages.
+*'''[[Effect::Increased music appreciation]]''' - The music enhancment from Pregabalin can be described as music sounding more detailed, 'higher quality', and even slowed  down on higher dosages.
 *'''[[Effect::Motivation enhancement]]''' - Like [[kratom]], pregabalin can be mildly sedative yet increase motivation in a [[stimulant]]-like fashion.
 *'''[[Effect::Immersion enhancement]]'''
 *'''[[Effect::Creativity enhancement]]''' - This effect is especially  noticeable  on higher doses.
-*'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At high/heavy doses, pregabalin can induce a mild dissociative state. The DPDR from Pregabalin can be increased and made more ''negative'' (less euphoric) by sleep deprivation.
+*'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At high/heavy doses, Pregabalin can induce a mild dissociative state. The DPDR from Pregabalin can be increased and made more ''negative'' (dysphoric) by sleep deprivation.
 *'''[[Effect::Suicidal ideation]]''' - In very huge doses this effect can lead to suicide attempts, sleep deprivation may increase this effect.
-*'''[[Effect::Psychosis]]''' - Even at medicinal doses, pregabalin has been shown to have psychotic side effects in minority of it's users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia.
+*'''[[Effect::Psychosis]]''' - Even at medicinal doses, Pregabalin has been shown to have psychotic side effects in minority of it's users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia.
-*'''[[Effect::Mania]]''' - Even if pregabalin is used to treat bipolar disorder <ref> https://pubmed.ncbi.nlm.nih.gov/23040739/ </ref>,it can cause mania (even in medical doses in certain cases). <ref>https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12012 </ref>. In recreational settings, in high / very high recreational doses or/ and when the user is sleep deprived , this effect can occur, but its still not a part of the typical Pregabalin experience, this effect can be low in intensity (hypomania) or go hand in hand with [[Psychosis]] and appear as a full blown manic psychosis. It is important to acknowledge this effect is very, very rare.
+*'''[[Effect::Mania]]''' - Even if Pregabalin is used to treat bipolar disorder <ref> https://pubmed.ncbi.nlm.nih.gov/23040739/ </ref>,it can cause mania (even in medical doses in certain cases). <ref>https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12012 </ref>. In recreational settings, in high / very high recreational doses or/ and when the user is sleep deprived , this effect can occur, but its still not a part of the typical Pregabalin experience, this effect can be low in intensity (hypomania) or go hand in hand with [[Psychosis]] and appear as a full blown manic psychosis. It is important to acknowledge this effect is very, very rare.
 *'''[[Effect::Thought deceleration]]'''
@@ Line 106: / Line 106: @@
 }}
 {{effects/aftereffects|
-The effects during a  [[offset]] of an [[Pregabalin]] experience are generally posetive and more similar to an 'afterglow' rather then a 'hangover'. These effects are ussaly very mild compared to [[peak]] effects. The after effects of [[Pregabalin]]  are:
+The effects during a  [[offset]] of an [[Pregabalin]] experience are generally positive and more similar to an 'afterglow' rather then a 'hangover'. These effects are usually very mild compared to [[peak]] effects. The after effects of [[Pregabalin]]  are:
 *'''[[Effect::Motivation enhancement]]''' - Pregabalin is usually mentally stimulating, and the ''afterglow'' is similar. Since the high is mostly gone, this can lead to productivity enhancement.
 *'''[[Effect::Increased music appreciation]]''' - This effect is not as strong as it would be in the high, but music is noticeably enhanced and sounds more detailed.