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SAM-e: Difference between revisions
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{{SubstanceBox/SAM-e}} | {{SubstanceBox/SAM-e}} | ||
'''S-Adenosyl-L-methionine''' (also called '''S-Adenosyl methionine''', '''Ademethionine''' and commonly as '''SAMe''' and '''SAM-e''') is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation in biological organisms.<ref>Homocysteine. | https://www.ncbi.nlm.nih.gov/pubmed/10762063</ref> SAMe is | '''S-Adenosyl-L-methionine''' (also called '''S-Adenosyl methionine''', '''Ademethionine''' and commonly as '''SAMe''' and '''SAM-e''') is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation in biological organisms.<ref>Homocysteine. | https://www.ncbi.nlm.nih.gov/pubmed/10762063</ref> SAMe is the amino acid methionine bound to an adenosine molecule that circulates in the blood naturally and acts as a 'methyl donor'. A methyl group in chemistry is simply a carbon molecule (bound to some hydrogens), and donating a methyl group to other molecules can accelerate or preserve reactions in the body as a form of metabolic 'maintenance'.{{citation needed}} | ||
SAM-e is available over the counter and by prescription in the treatment of depression and osteoarthritis. It is generally distributed in enteric-coated tablets, which allows the supplement to pass through the low pH environment of the stomach to the gastrointestinal tract, raising the bioavaliability by 600%.<ref>Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156851/</ref> | SAM-e is available over the counter and by prescription in the treatment of depression and osteoarthritis. It is generally distributed in enteric-coated tablets, which allows the supplement to pass through the low pH environment of the stomach to the gastrointestinal tract, raising the bioavaliability by 600%.<ref>Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156851/</ref> | ||
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===Experience reports=== | ===Experience reports=== | ||
There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here: | There are currently no anecdotal reports which describe the effects of this compound within our [[experience index]]. Additional experience reports can be found here: | ||
* [https://www.erowid.org/experiences/subs/exp_SAMe.shtml Erowid Experience Vaults: SAMe] | |||
*[https://www.erowid.org/experiences/subs/exp_SAMe.shtml Erowid Experience Vaults: SAMe] | |||
==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
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==Legal status== | ==Legal status== | ||
*'''United States''' - SAM-e is approved and legal over the counter for purchase. | *'''United States''' - SAM-e is approved and legal over the counter for purchase. | ||
*'''Germany''' - SAM-e is sold as a dietary supplement. | *'''Germany''' - SAM-e is sold as a dietary supplement. | ||
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==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Nootropics]] | *[[Nootropics]] | ||
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*[[Ashwagandha]] | *[[Ashwagandha]] | ||
*[[Creatine]] | *[[Creatine]] | ||
==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/S-Adenosyl_methionine S-Adenosyl methionine (Wikipedia)] | *[https://en.wikipedia.org/wiki/S-Adenosyl_methionine S-Adenosyl methionine (Wikipedia)] | ||
*[https://examine.com/supplements/s-adenosyl-methionine/ S-Adenosyl methionine (Examine)] | *[https://examine.com/supplements/s-adenosyl-methionine/ S-Adenosyl methionine (Examine)] | ||