Talk:Loperamide: Difference between revisions

Line 89:

*'''[[Stimulants]]''' - Because loperamide increases BPM and BP and stimulants also do this, cardiac arrest, hypertensive crisis, stroke, and heart attack all become much more likely to occur. Besides it can be dangerous to combine depressants with stimulants due to the risk of accidental excessive intoxication. Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states.

*'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.

*'''[[CYP450 3A4 or 2C8 inhibitors]]''' - Coadministration with drugs that enhance the gastrointestinal absorption or inhibit the metabolism of loperamide (e.g., potent CYP450 3A4 or 2C8 inhibitors) may increase the plasma concentrations and adverse effects of loperamide. <ref> https://www.drugs.com/drug-interactions/erythromycin-with-loperamide-simethicone-1009-0-1483-0.html?professional=1 </ref> That includes; erythromycin, ritonavir, grapefruit.

==Legal status==

@@ Line 89: / Line 89: @@
 *'''[[Stimulants]]''' - Because loperamide increases BPM and BP and stimulants also do this, cardiac arrest, hypertensive crisis, stroke, and heart attack all become much more likely to occur. Besides it can be dangerous to combine depressants with stimulants due to the risk of accidental excessive intoxication. Stimulants mask the sedative effect of depressants, which is the main factor most people use to gauge their level of intoxication. Once the stimulant effects wear off, the effects of the depressant will significantly increase, leading to intensified disinhibition, motor control loss, and dangerous black-out states.
 *'''[[Dissociatives]]''' - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the [[recovery position]] or have a friend move them into it.
+*'''[[CYP450 3A4 or 2C8 inhibitors]]''' -  Coadministration with drugs that enhance the gastrointestinal absorption or inhibit the metabolism of loperamide (e.g., potent CYP450 3A4 or 2C8 inhibitors) may increase the plasma concentrations and adverse effects of loperamide. <ref> https://www.drugs.com/drug-interactions/erythromycin-with-loperamide-simethicone-1009-0-1483-0.html?professional=1 </ref> That includes; erythromycin, ritonavir, grapefruit.
 ==Legal status==