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Piracetam: Difference between revisions
>Mardo Add referenced legal status pertaining to the Czech Republic. |
>Mardo Harm potential for brain hemorrhage and kidney failure patients. |
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==Toxicity and harm potential== | ==Toxicity and harm potential== | ||
Adverse effects, although rare and of short duration are limited to [[anxiety]], [[wakefulness|insomnia]], [[sedation|drowsiness]], [[headaches]] and [[irritability|agitation]]. It may be safe for up to 18 months in humans at doses of 3.2g daily with one year-long study in ambulatory patients with Alzheimer's using 8g daily reporting no side effects.<ref>Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy. | http://www.ncbi.nlm.nih.gov/pubmed/11346373</ref> However, a possibility for adverse drug-drug interactions persists for piracetam due to it interacting with blood in an anti-clotting manner | Adverse effects, although rare and of short duration are limited to [[anxiety]], [[wakefulness|insomnia]], [[sedation|drowsiness]], [[headaches]] and [[irritability|agitation]]. It may be safe for up to 18 months in humans at doses of 3.2g daily with one year-long study in ambulatory patients with Alzheimer's using 8g daily reporting no side effects.<ref>Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy. | http://www.ncbi.nlm.nih.gov/pubmed/11346373</ref> However, a possibility for adverse drug-drug interactions persists for piracetam due to it interacting with blood in an anti-clotting manner. Therefore, caution should be taken when pairing piracetam with pharmaceutical blood thinning agents such as Warfarin or potent nutraceutical options and individuals prone to brain hemorrhaging are discouraged from using piracetam. | ||
Patients with renal insufficiency should also not use Piracetam. | |||
No fatal overdoses associated with piracetam use have been reported as of 2016. In animal models (rodents, dogs, and marmoset), an [[LD50|LD<sub>50</sub>]] failed to be established at the dosage of 8-10g/kg. | No fatal overdoses associated with piracetam use have been reported as of 2016. In animal models (rodents, dogs, and marmoset), an [[LD50|LD<sub>50</sub>]] failed to be established at the dosage of 8-10g/kg. | ||
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*'''United Kingdom:''' Piracetam and other racetams are prescription only drugs; however, there is no penalty for possession or importing them. | *'''United Kingdom:''' Piracetam and other racetams are prescription only drugs; however, there is no penalty for possession or importing them. | ||
*'''New Zealand:''' Piracetam is considered a prescription drug, and as such will be seized by the Ministry of Health. It is not able to be imported without a signed note from a doctor. | *'''New Zealand:''' Piracetam is considered a prescription drug, and as such will be seized by the Ministry of Health. It is not able to be imported without a signed note from a doctor. | ||
==See also== | ==See also== | ||