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Pregabalin: Difference between revisions
>MeyveliPasta Added interaction markup. |
>Nutmeg enjoyer 11 I have lately been using pregabalin a lot, from doses of 350-1000 mg. Ive asked people on gaba subreddits too about this and it seems certian amount of people reallt get visaul effects from pregabalin and psychotic effects. Me and my friend have inetionaly sleep deprived ourslef to test the theaory even only slight sleep deprivation (20 hours) can make pregabalin: ive even read sceintifc cases of psychotic and manic effects caused by pregabalin, ive editet subjective effects to include this. |
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Each individual can have a very different reaction to pregabalin, thus it is essential to start at lower doses to ensure that it does not have any severe adverse effects such as peripheral edema or muscle pain. | Each individual can have a very different reaction to pregabalin, thus it is essential to start at lower doses to ensure that it does not have any severe adverse effects such as peripheral edema or muscle pain. | ||
{{Preamble/SubjectiveEffects}} | {{Preamble/SubjectiveEffects}} | ||
{{effects/base | {{effects/base | ||
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*'''[[Effect::Visual acuity suppression]]''' - At high dosages, pregabalin can induce slightly blurred vision. | *'''[[Effect::Visual acuity suppression]]''' - At high dosages, pregabalin can induce slightly blurred vision. | ||
*'''[[Effect::Tracers]]''' - This effect can be seen at high doses and is generally quite mild. It generally does not extend past level 2. | *'''[[Effect::Tracers]]''' - This effect can be seen at high doses and is generally quite mild. It generally does not extend past level 2. | ||
*'''[[Effect::Depth perception distortions]]''' - This effect is quite mild and only appears at very high doses. | |||
*'''[[Effect::Object alteration]]''' | |||
*'''[[Effect::Drifting]]''' | |||
*'''[[Effect::After images]]''' and *'''[[Effect::Frame rate suppression]]''' at high / very high doses. These 2 effects together can make your vision feel more 'slow'. | |||
*'''[[Effect::Double vision]]'' - This effect is quite mild and inconsistently appears at high doses. Sleep deprivation might magnify this effect. | |||
====Hallucinatory states==== | ====Hallucinatory states==== | ||
While Pregabalin isn't commonly thought off as a ''trip'' drug, it still can cause dissocative and even psychotic like effects at higher doses. Sleep deprivation and genetics might play a roll into the hallucinatory states of Pregabalin. Pregabalin's hallucinatory states are (but not limited to) : | |||
*'''[[Effect::Internal hallucination]]''' - At high dosages, one may experience dream-like states and [[hypnagogia]]. | *'''[[Effect::Internal hallucination]]''' - At high dosages, one may experience dream-like states and [[hypnagogia]]. | ||
*'''[[Effect::External hallucination]]''' - This effect is rare and only appears on high/very high and/or when the user is sleep deprived. This effect can be delirious / psychotic in nature. It can include : [[Object activation ]], [[Shadow people]] and [[Transformations]]. It may include even non existent people and animals from a distance, but once the user comes closer they may disappear. | |||
}} | }} | ||
{{effects/disconnective| | {{effects/disconnective| | ||
*'''[[Effect::Visual disconnection]]''' - This effect is generally quite mild and appears inconsistently at | *'''[[Effect::Visual disconnection]]''' - This effect is generally quite mild and appears inconsistently at high doses. It results in feeling as if one's sense of vision is distant or vague and being viewed through a screen or window. However, Pregabalin is rarely reported to cause [[holes, spaces and voids]] or [[Visual_disconnection#Structures|hallucinatory structures]] , it can in some users (sleep deprivation might enhance this effect) but it is far from the typical experience. Pressing on your eyes while sitting in a dark room on a high - very high dose may result in very mild [[structures]] and [[sceneries]] | ||
}} | }} | ||
|{{effects/cognitive| | |{{effects/cognitive| | ||
The cognitive effects of pregabalin can be broken down into several components which progressively intensify proportional to dosage. Pregabalin's headspace is comparable to a more clear-headed [[alcohol]] or [[benzodiazepine]] intoxication, although it can take a more [[dissociative]] turn at | The cognitive effects of pregabalin can be broken down into several components which progressively intensify proportional to dosage. Pregabalin's headspace is comparable to a more clear-headed [[alcohol]] or [[benzodiazepine]] intoxication, although it can take a more [[dissociative]] turn at high dosages. | ||
The most prominent of these cognitive effects generally include: | The most prominent of these cognitive effects generally include: | ||
*'''[[Effect::Analysis suppression]]''' | *'''[[Effect::Analysis suppression]]''' | ||
* '''[[Effect::Empathy, affection, and sociability enhancement]]''' - Pregabalin presents distinct [[entactogen|entactogen/empathogenic]] effects. In large contrast to [[benzodiazepines]] (which merely increase sociability through [[disinhibition]]), at high dosages pregabalin directly increases the urge to communicate with others with feelings of empathy, love, closeness and connection being well-defined. These effects, although weaker than that of [[MDMA]], are still prominent. | * '''[[Effect::Empathy, affection, and sociability enhancement]]''' - Pregabalin presents distinct [[entactogen|entactogen/empathogenic]] effects. In large contrast to [[benzodiazepines]] (which merely increase sociability through [[disinhibition]]), at high dosages pregabalin directly increases the urge to communicate with others with feelings of empathy, love, closeness and connection being well-defined. These effects, although weaker than that of [[MDMA]], are still prominent. | ||
*'''[[Effect::Suggestibility enhancement]]''' | |||
*'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances. | *'''[[Effect::Amnesia]]''' - Compared to [[benzodiazepines]], pregabalin is only mildly amnesiac if not combined with other depressants. With chronic usage or high dosages, one should expect more "tip of the tongue" moments and impaired short-term memory (e.g., walking into a room and forgetting what you were supposed to do there). Total blackouts do not seem to occur except in combination with other substances. | ||
*'''[[Effect::Anxiety suppression]]''' | *'''[[Effect::Anxiety suppression]]''' | ||
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*'''[[Effect::Disinhibition]]''' | *'''[[Effect::Disinhibition]]''' | ||
*'''[[Effect::Dream potentiation]]''' | *'''[[Effect::Dream potentiation]]''' | ||
*'''[[Effect::Increased music appreciation]]''' | *'''[[Effect::Increased music appreciation]]''' - The music enhancment from Pregabalin can be described as music sounding more detailed, 'higher quality', and even slowed down on higher dosages. | ||
*'''[[Effect::Motivation enhancement]]''' - Like [[kratom]], pregabalin can be mildly sedative yet increase motivation in a [[stimulant]]-like fashion. | *'''[[Effect::Motivation enhancement]]''' - Like [[kratom]], pregabalin can be mildly sedative yet increase motivation in a [[stimulant]]-like fashion. | ||
*'''[[Effect::Immersion enhancement]]''' | *'''[[Effect::Immersion enhancement]]''' | ||
*'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At | *'''[[Effect::Creativity enhancement]]''' - This effect is especially noticeable on higher doses. | ||
*'''[[Effect::Suicidal ideation]]''' | *'''[[Effect::Depersonalization]]''' ''and'' '''[[Effect::Derealization]]''' - At high/heavy doses, Pregabalin can induce a mild dissociative state. The DPDR from Pregabalin can be increased and made more ''negative'' (less euphoric) by sleep deprivation. | ||
*'''[[Effect::Suicidal ideation]]''' - In very huge doses this effect can lead to suicide attempts, sleep deprivation may increase this effect. | |||
*'''[[Effect::Psychosis]]''' - Even at medicinal doses, Pregabalin has been shown to have psychotic side effects in minority of it's users <ref> https://www.sciencedirect.com/science/article/pii/S105913110600029X#:~:text=Pregabalin%20is%20an%20effective%20anticonvulsant,mild%20and%20transient%20in%20nature.&text=However%2C%20physicians%20should%20be%20aware,be%20associated%20with%20psychotic%20symptoms.</ref> <ref> https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-020-0395-6</ref>. This effect is strongly potentiate by sleep deprivation and may be higher for people with genetic risks of psychosis / schizophrenia. | |||
*'''[[Effect::Mania]]''' - Even if Pregabalin is used to treat bipolar disorder <ref> https://pubmed.ncbi.nlm.nih.gov/23040739/ </ref>,it can cause mania (even in medical doses in certain cases). <ref>https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12012 </ref>. In recreational settings, in high / very high recreational doses or/ and when the user is sleep deprived , this effect can occur, but its still not a part of the typical Pregabalin experience, this effect can be low in intensity (hypomania) or go hand in hand with [[Psychosis]] and appear as a full blown manic psychosis. It is important to acknowledge this effect is very, very rare. | |||
*'''[[Effect::Thought deceleration]]''' | *'''[[Effect::Thought deceleration]]''' | ||
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*'''[[Effect::Auditory enhancement|Enhancements]]''' | *'''[[Effect::Auditory enhancement|Enhancements]]''' | ||
*'''[[Effect::Auditory distortion|Distortions]]''' - These are usually mild and only present at extremely high doses. | *'''[[Effect::Auditory distortion|Distortions]]''' - These are usually mild and only present at extremely high doses. | ||
*'''[[Effect::Auditory hallucination]]''' - Pregabalin is known to have psychotic / delirious side effects in certain people, especially at higher doses, with low tolerance and if the user was sleep deprived. The hallucinations can be tinnitus, voices , and other delirious sounds. | |||
}} | |||
{{effects/aftereffects| | |||
The effects during a [[offset]] of an [[Pregabalin]] experience are generally posetive and more similar to an 'afterglow' rather then a 'hangover'. These effects are ussaly very mild compared to [[peak]] effects. The after effects of [[Pregabalin]] are: | |||
*'''[[Effect::Motivation enhancement]]''' - Prefabbing is usually mentally stimulating, and the ''afterglow'' is similar. Since the high is mostly gone, this can lead to productivity enhancement. | |||
*'''[[Effect::Increased music appreciation]]''' - This effect is not as strong as it would be in the high, but music is noticeably enhanced and sounds more detailed. | |||
*'''[[Effect::Muscle relaxation]]''' - This effect is not as strong as the high but its still here in the afterglow. | |||
*'''[[Effect::Motor control loss]]''' - This effect is weaker then the ''high'' but is still noticeable to the user. Driving while in the ''afterglow'' / comedown is a bad idea. | |||
*'''[[Effect::Dizziness]]''' - The after effects are mostly positive with Pregabalin, but dizziness can still be here, especially after doing a high dose. | |||
}} | }} | ||
}} | }} | ||
===Experience reports=== | ===Experience reports=== | ||