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Benzodiazepines: Difference between revisions
>Pharmreduction changed order |
>Pharmreduction →Substituted 1,4-benzodiazepines: rearranged benzo list to better show relationships |
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{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
! scope="col" | '''Compound''' | ! scope="col" |'''Compound''' | ||
! scope="col" style="width: 50px;" | '''R<sub>1</sub>''' | ! scope="col" style="width: 50px;" |'''R<sub>1</sub>''' | ||
! scope="col" style="width: 50px;" | '''R<sub>2</sub>''' | ! scope="col" style="width: 50px;" |'''R<sub>2</sub>''' | ||
! scope="col" style="width: 50px;" | '''R<sub>3</sub>''' | ! scope="col" style="width: 50px;" |'''R<sub>3</sub>''' | ||
! scope="col" style="width: 50px;" | '''R<sub>4</sub>''' | ! scope="col" style="width: 50px;" |'''R<sub>4</sub>''' | ||
! scope="col" style="width: 50px;" | '''R<sub>5</sub>''' | ! scope="col" style="width: 50px;" |'''R<sub>5</sub>''' | ||
! scope="col" style="width: 50px;" | '''R<sub>6</sub>''' | ! scope="col" style="width: 50px;" |'''R<sub>6</sub>''' | ||
! scope="col" style="width: 50px;" | '''R<sub>7</sub>''' | ! scope="col" style="width: 50px;" |'''R<sub>7</sub>''' | ||
! scope="col" | '''Structure''' | ! scope="col" |'''Structure''' | ||
|- | |- | ||
| [[Chlordiazepoxide]] || | |[[Chlordiazepoxide]]|| ||NHCH<sub>3</sub>||H||O||C<sub>6</sub>H<sub>5</sub>||H||Cl||[[File:Chlordiazepoxide.svg|170px]] | ||
|- | |- | ||
| [[Bromazepam]] || H || =O || H || | |[[Bromazepam]]||H||=O||H|| ||C<sub>5</sub>H<sub>4</sub>N||H||Br||[[File:Bromazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Flubromazepam]]||H||=O||H|| ||C<sub>6</sub>H<sub>4</sub>F||H||Br||[[File:Flubromazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Diazepam]]||CH<sub>3</sub>||=O||H|| ||C<sub>6</sub>H<sub>5</sub>||H||Cl||[[File:Diazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Diclazepam]]||CH<sub>3</sub>||=O||H|| ||C<sub>6</sub>H<sub>4</sub>Cl||H||Cl||[[File:Diclazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Lorazepam]]||H||=O||OH|| ||C<sub>6</sub>H<sub>4</sub>Cl||H||Cl||[[File:Lorazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Oxazepam]]||H||=O||OH|| ||C<sub>6</sub>H<sub>5</sub>||H||Cl||[[File:Oxazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Temazepam]]||CH<sub>3</sub>||=O||OH|| ||C<sub>6</sub>H<sub>5</sub>||H||Cl||[[File:Temazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Cinolazepam]]||CH<sub>2</sub>CH<sub>2</sub>≡N||=O||OH|| ||C<sub>6</sub>H<sub>4</sub>F||H||Cl||[[File:Cinolazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Clonazepam]]||H||=O||H|| ||C<sub>6</sub>H<sub>4</sub>Cl||H||NO<sub>2</sub>||[[File:Clonazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Flunitrazepam]]||CH<sub>3</sub>||=O||H|| ||C<sub>6</sub>H<sub>4</sub>F||H||NO<sub>2</sub>||[[File:Flunitrazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Meclonazepam]]||H||=O||CH<sub>3</sub>|| ||C<sub>6</sub>H<sub>4</sub>Cl||H||NO<sub>2</sub>||[[File:Meclonazepam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Nifoxipam]]||H||=O||OH|| ||C<sub>6</sub>H<sub>4</sub>F||H||NO<sub>2</sub>||[[File:Nifoxipam.svg|170px]] | ||
|- | |- | ||
| [[Alprazolam]] || C(CH<sub>3</sub>)=N- || =N- || H || | |[[Alprazolam]]||C(CH<sub>3</sub>)=N-||=N-||H|| ||C<sub>6</sub>H<sub>5</sub>||H||Cl||[[File:Alprazolam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Pyrazolam]]||C(CH<sub>3</sub>)=N-||=N-||H|| ||C<sub>5</sub>H<sub>4</sub>N||H||Br||[[File:Pyrazolam.svg|170px]] | ||
|- | |- | ||
| [[Flubromazolam]] || C(CH<sub>3</sub>)=N- || =N- || H || | |[[Flubromazolam]]||C(CH<sub>3</sub>)=N-||=N-||H|| ||C<sub>6</sub>H<sub>4</sub>F||H||Br||[[File:Flubromazolam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Midazolam]]||C(CH<sub>3</sub>)=N-||=N-||H|| ||C<sub>6</sub>H<sub>4</sub>F||H||Cl||[[File:Midazolam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Triazolam]]||C(CH<sub>3</sub>)=N-||=N-||H|| ||C<sub>6</sub>H<sub>4</sub>Cl||H||Cl||[[File:Triazolam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Clonazolam]]||C(CH<sub>3</sub>)=N-||=N-||H|| ||C<sub>6</sub>H<sub>4</sub>Cl||H||NO<sub>2</sub>||[[File:Clonazolam.svg|170px]] | ||
|- | |- | ||
| [[ | |[[Flunitrazolam]]||C(CH<sub>3</sub>)=N-||=N-||H|| ||C<sub>6</sub>H<sub>4</sub>F||H||NO<sub>2</sub>||[[File:Flunitrazolam.svg|170px]] | ||
|- | |- | ||
| [[Flumazenil]] || CH=N- || C(C<sub>3</sub>H<sub>5</sub>O<sub>2</sub>)- || H || CH<sub>3</sub> || =O || H || F || [[File:Flumazenil.svg|170px]] | |[[Flumazenil]]||CH=N-||C(C<sub>3</sub>H<sub>5</sub>O<sub>2</sub>)-||H||CH<sub>3</sub>||=O||H||F||[[File:Flumazenil.svg|170px]] | ||
|- | |- | ||
| [[Bretazenil]] || CH=N- || C(C<sub>5</sub>H<sub>9</sub>O<sub>2</sub>)- || CH<sub>2</sub>CH<sub>2</sub>- || CH<sub>2</sub>- || =O || Br || H || [[File:Bretazenil.svg|170px]] | |[[Bretazenil]]||CH=N-||C(C<sub>5</sub>H<sub>9</sub>O<sub>2</sub>)-||CH<sub>2</sub>CH<sub>2</sub>-||CH<sub>2</sub>-||=O||Br||H||[[File:Bretazenil.svg|170px]] | ||
|- | |- | ||
| [[Clozapine]] || H || CH=CH- || CH=CH(Cl)- || | |[[Clozapine]]||H||CH=CH-||CH=CH(Cl)-|| ||C<sub>5</sub>H<sub>11</sub>N<sub>2</sub>||H||H||[[File:Clozapine.svg|170px]] | ||
|- | |- | ||
| [[Dibenzepin]] || CH<sub>3</sub> || CH=CH- || CH=CH- || C<sub>4</sub>H<sub>10</sub>N || =O || H || H || [[File:Dibenzepin.svg|170px]] | |[[Dibenzepin]]||CH<sub>3</sub>||CH=CH-||CH=CH-||C<sub>4</sub>H<sub>10</sub>N||=O||H||H||[[File:Dibenzepin.svg|170px]] | ||
|- | |- | ||
|} | |} | ||