Codeine: Difference between revisions

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==Chemistry==
==Chemistry==
Codeine, or 3-methylmorphine, is an opioid of the morphinan class. Codeine and other molecules of this class contain a polycyclic core of three benzene rings fused in a zig-zag pattern called phenanthrene. A fourth nitrogen-containing ring is fused to the phenanthrene at R<sub>9</sub> and R<sub>13</sub> with the nitrogen member looking at R<sub>17</sub> of the combined structure. This structure is called morphinan. Codeine (along with other morphinans) contains an ether bridge between two of its rings, connecting R<sub>4</sub> and R<sub>5</sub> through an oxygen group. It contains a hydroxy group (OH-) bound at R<sub>6</sub> and a methyl group located on the nitrogen atom at R<sub>17</sub>.  
[https://insomniatabletsuk.com/product/codeine-phosphate-15-mg/ Codeine], or 3-methylmorphine, is an opioid of the morphinan class. Codeine and other molecules of this class contain a polycyclic core of three benzene rings fused in a zig-zag pattern called phenanthrene. A fourth nitrogen-containing ring is fused to the phenanthrene at R<sub>9</sub> and R<sub>13</sub> with the nitrogen member looking at R<sub>17</sub> of the combined structure. This structure is called morphinan. Codeine (along with other morphinans) contains an ether bridge between two of its rings, connecting R<sub>4</sub> and R<sub>5</sub> through an oxygen group. It contains a hydroxy group (OH-) bound at R<sub>6</sub> and a methyl group located on the nitrogen atom at R<sub>17</sub>.  


On the same ring containing the hydroxy group, codeine contains a double bond which [[dihydrocodeine]] lacks. Codeine is closely related to morphine as both contain an oxygen group at R<sub>3</sub>, but this oxygen group in codeine is substituted by a methyl group (making a methoxy group). Codeine is analogous to the other morphinans including [[dihydrocodeine]], [[heroin]], [[ethylmorphine]], [[hydrocodone]], and [[oxycodone]].
On the same ring containing the hydroxy group, codeine contains a double bond which [[dihydrocodeine]] lacks. Codeine is closely related to morphine as both contain an oxygen group at R<sub>3</sub>, but this oxygen group in codeine is substituted by a methyl group (making a methoxy group). Codeine is analogous to the other morphinans including [[dihydrocodeine]], [[heroin]], [[ethylmorphine]], [[hydrocodone]], and [[oxycodone]].