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Serotonin: Difference between revisions
>Azed Added multiple citations and added to sections in sections one and two, in additon to sections on Reuptake inhibitors, and Serotonin syndrome. |
>Nukekiller125 m Added Risperidone and Olanzapine as examples of 5-HT2A inverse agonists |
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A serotonin [[agonist#Inverse agonists |inverse agonist]] activates a serotonin receptor but has the opposite pharmacological effect. Inverse agonists trigger a specific response from a receptor, whereas antagonists inhibit the activity of the receptor. | A serotonin [[agonist#Inverse agonists |inverse agonist]] activates a serotonin receptor but has the opposite pharmacological effect. Inverse agonists trigger a specific response from a receptor, whereas antagonists inhibit the activity of the receptor. | ||
Some antipsychotics such as | Some antipsychotics such as Pimavanserin, Risperidone and Olanzapine are 5-HT<sub>2A</sub> inverse agonists. 5-HT<sub>2A</sub> inverse agonists have been researched for the treatment of insomnia with limited success. | ||
====Releasing agents==== | ====Releasing agents==== | ||
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==See also== | ==See also== | ||
*[[Responsible use]] | *[[Responsible use]] | ||
*[[Neurotransmitter]] | *[[Neurotransmitter]] | ||
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==External links== | ==External links== | ||
*[https://en.wikipedia.org/wiki/Serotonin Serotonin (Wikipedia)] | *[https://en.wikipedia.org/wiki/Serotonin Serotonin (Wikipedia)] | ||
*[https://en.wikipedia.org/wiki/Tryptophan Tryptophan (Wikipedia)] | *[https://en.wikipedia.org/wiki/Tryptophan Tryptophan (Wikipedia)] | ||
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==Literature== | ==Literature== | ||
*Sodhi, M., & Sanders-Bush, E. (2004). Serotonin and brain development. International Review of Neurobiology, 59, 111-74. https://doi.org/10.1016/S0074-7742(04)59006-2 | *Sodhi, M., & Sanders-Bush, E. (2004). Serotonin and brain development. International Review of Neurobiology, 59, 111-74. https://doi.org/10.1016/S0074-7742(04)59006-2 | ||
*Nichols, D.E., & Nichols, C.D. (2008). Serotonin receptors. Chemical Reviews, 108 5, 1614-41. https://doi.org/10.1021/cr078224o | *Nichols, D.E., & Nichols, C.D. (2008). Serotonin receptors. Chemical Reviews, 108 5, 1614-41. https://doi.org/10.1021/cr078224o | ||
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[[Category:Neurotransmitter]] | [[Category:Neurotransmitter]] | ||
[[Category:Tryptamine]] | [[Category:Tryptamine]] | ||
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